Evidence accumulated over the past several decades suggests that diet and physical activity and the outcomes of those behaviors, overweight and obesity, contribute to 30-40% of cancer cases. Further, diet and physical activity can make an important contribution to cancer management across the cancer continuum, affecting prognosis and long-term survival. Disentangling the effects of diet, physical activity, obesity and associated lifestyle factors is challenging. A major challenge in this area of research is the recognized limitations in the traditional methods of diet and physical activity assessment. Also, sustained changes in eating and activity behaviors that may reduce cancer risk and progression are most likely to be achieved when evidence-based behavioral and technological strategies are applied. With cancer research efforts increasingly focused on the energy balance and adiposity, the resource scope has expanded in this submission to offer state-of-the-art physical activity and body composition measurements and monitoring. The Diet and Physical Activity Shared Resource provides services in four areas: dietary assessment and monitoring, including the collection and analysis of dietary data utilizing a variety of approaches, and the development of food content databases and biomarker/biochemical laboratory analysis;behavioral/lifestyle coaching and intervention-related services targeting diet, physical activity, and weight loss;physical activity and sedentary behavior assessment including objective measurements of physical activity and sedentary behavior, using accelerometers and other state-of-the-art tools and technologies;and body composition analysis, including regional fat and lean mass, using dual-energy x-ray technology. Objectives of this shared resource are to enable Cancer Center members to have access to state-of-the-art services provided by individuals with expertise in these specialized disciplines, diet and physical activity assessment and behavior change, and thus to contribute to the core scientific mission that defines the primary goals of the Center. Since the prior CCSG review, the resource has contributed to scientific efforts in numerous major grants and projects.

Public Health Relevance

This Shared Resource provides services in the specialized disciplines of diet and physical activity to the broad range of Cancer Center investigators who have training in general behavioral, social, and medical sciences. The resource has enabled successful scientific efforts in numerous major grants and projects and contributes to the core scientific mission that defines the primary goals of the Center.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA023100-28
Application #
8934960
Study Section
Subcommittee G - Education (NCI)
Program Officer
Shafik, Hasnaa
Project Start
2014-07-21
Project End
2019-04-30
Budget Start
2014-07-21
Budget End
2015-04-30
Support Year
28
Fiscal Year
2014
Total Cost
$196,387
Indirect Cost
$68,424
Name
University of California San Diego
Department
Type
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Sen, Supriya; Langiewicz, Magda; Jumaa, Hassan et al. (2015) Deletion of serine/arginine-rich splicing factor 3 in hepatocytes predisposes to hepatocellular carcinoma in mice. Hepatology 61:171-83
Hoffmann, Hanne M; Tamrazian, Anika; Xie, Huimin et al. (2014) Heterozygous deletion of ventral anterior homeobox (vax1) causes subfertility in mice. Endocrinology 155:4043-53
Hartman, Lisa L R; Crawford, John R; Makale, Milan T et al. (2014) Pediatric phase II trials of poly-ICLC in the management of newly diagnosed and recurrent brain tumors. J Pediatr Hematol Oncol 36:451-7
Williams, Richard T; Barnhill, Lisa M; Kuo, Huan-Hsien et al. (2014) Chimeras of p14ARF and p16: functional hybrids with the ability to arrest growth. PLoS One 9:e88219
Huang, Carlos P; Fofana, Mariama; Chan, Jefferson et al. (2014) Copper transporter 2 regulates intracellular copper and sensitivity to cisplatin. Metallomics 6:654-61
Paolini, Paul; Pick, Daniel; Lapira, Jennifer et al. (2014) Developmental and extracellular matrix-remodeling processes in rosiglitazone-exposed neonatal rat cardiomyocytes. Pharmacogenomics 15:759-74
Goellner, Eva M; Smith, Catherine E; Campbell, Christopher S et al. (2014) PCNA and Msh2-Msh6 activate an Mlh1-Pms1 endonuclease pathway required for Exo1-independent mismatch repair. Mol Cell 55:291-304
Glidewell-Kenney, Christine A; Trang, Crystal; Shao, Paul P et al. (2014) Neurokinin B induces c-fos transcription via protein kinase C and activation of serum response factor and Elk-1 in immortalized GnRH neurons. Endocrinology 155:3909-19
Jiang, P; Mukthavaram, R; Chao, Y et al. (2014) In vitro and in vivo anticancer effects of mevalonate pathway modulation on human cancer cells. Br J Cancer 111:1562-71
Jacques, Bonnie E; Montgomery 4th, William H; Uribe, Phillip M et al. (2014) The role of Wnt/*-catenin signaling in proliferation and regeneration of the developing basilar papilla and lateral line. Dev Neurobiol 74:438-56

Showing the most recent 10 out of 359 publications