Dartmouth's Norris Cotton Cancer Center (NCCC) submits this competitive renewal application for NCI Cancer Center Support Grant funding for Years 31-35. NCCC is a matrix Center at Dartmouth-Hitchcock Medical Center (DHMC), organized as an interdepartmental component of Dartmouth Medical School and DHMC, with overall responsibility for cancer research, cancer care, and educational and service activities in cancer. NCCC is dedicated to developing strategies to prevent and cure cancer through pioneering interdisciplinary research and translate new knowledge into meaningful preventive and therapeutic approaches. The past five years have been distinguished by significant accomplishments: With the support of its parent institutions, NCCC has taken advantage of its outstanding research facilities to support the growth of its cancer research enterprise, while moving aggressively to a more translational focus on both population-based preventive interventions and clinically based therapeutic research. Over the past funding period, NCCC has (1) strengthened Senior Leadership of the Center;(2) recruited outstanding faculty to strategic priorities;(3) enhanced the infrastructure for research;(4) secured enhanced institutional support;and (5) increased philanthropic resources dedicated to the cancer enterprise. NCCC pursues its mission by promoting collaboration among its 126 scientists and 6 Research Programs, and by facilitating their research efforts through support from 12 Shared Resources. NCCC Research Programs are focused in Cancer Epidemiology/ Chemoprevention, Cancer Control, Molecular Therapeutics, Cancer Mechanisms, Immunology/Cancer Immunotherapy, and Cancer Imaging/ Radiobiology. NCCC Shared Resources provide technology and expertise in Bioinformatics, Biostatistics, Clinical Pharmacology, Flow Cytometry/Cell Imaging, Genomics, Immune Monitoring, Molecular Biology, Pathology, Proteomics, Transgenics/Genetic Constructs, and the Office of Clinical Research. NCCC provides developmental funds to support the initial research efforts of new investigators, innovative and collaborative pilot projects, shared resources, and new technology/methodology. Current total funding for NCCC programs of $54.7M includes $26.5M in NCI-sponsored projects. This application requests continuation of our CCSG to provide partial support for these developmental efforts and for the leadership, administrative, planning and evaluation, shared resources, protocol-specific research, protocol review and monitoring, and other components that are crucial to the maintenance of a coordinated and interactive interdisciplinary program in cancer research.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA023108-35
Application #
8391722
Study Section
Subcommittee G - Education (NCI)
Program Officer
Ciolino, Henry P
Project Start
1997-08-04
Project End
2014-11-30
Budget Start
2012-12-01
Budget End
2014-11-30
Support Year
35
Fiscal Year
2013
Total Cost
$2,922,577
Indirect Cost
$1,072,845
Name
Dartmouth College
Department
Pediatrics
Type
Schools of Medicine
DUNS #
041027822
City
Hanover
State
NH
Country
United States
Zip Code
03755
Zhang, Sai; Zhou, Jingtian; Hu, Hailin et al. (2016) A deep learning framework for modeling structural features of RNA-binding protein targets. Nucleic Acids Res 44:e32
Macura, Sherrill L; Lathrop, Melissa J; Gui, Jiang et al. (2016) Blocking CXCL9 Decreases HIV-1 Replication and Enhances the Activity of Prophylactic Antiretrovirals in Human Cervical Tissues. J Acquir Immune Defic Syndr 71:474-82
Whipple, Chery A; Boni, Andrea; Fisher, Jan L et al. (2016) The mitogen-activated protein kinase pathway plays a critical role in regulating immunological properties of BRAF mutant cutaneous melanoma cells. Melanoma Res 26:223-35
Sargent, Jennifer L; Li, Zhenghui; Aliprantis, Antonios O et al. (2016) Identification of Optimal Mouse Models of Systemic Sclerosis by Interspecies Comparative Genomics. Arthritis Rheumatol 68:2003-15
Hill, Courtney A; Beach, Michael; Smith, Mark C et al. (2016) Incidence of and Factors Associated With Hypogeusia in Healthy Children. JAMA Otolaryngol Head Neck Surg 142:229-33
Kim, Jung-Sik; He, Xiaoyuan; Orr, Bernardo et al. (2016) Intact Cohesion, Anaphase, and Chromosome Segregation in Human Cells Harboring Tumor-Derived Mutations in STAG2. PLoS Genet 12:e1005865
Yang, Wei; Hosford, Sarah R; Dillon, Lloye M et al. (2016) Strategically Timing Inhibition of Phosphatidylinositol 3-Kinase to Maximize Therapeutic Index in Estrogen Receptor Alpha-Positive, PIK3CA-Mutant Breast Cancer. Clin Cancer Res 22:2250-60
Beach, Michael L; Cohen, Daniel M; Gallagher, Susan M et al. (2016) Major Adverse Events and Relationship to Nil per Os Status in Pediatric Sedation/Anesthesia Outside the Operating Room: A Report of the Pediatric Sedation Research Consortium. Anesthesiology 124:80-8
Allaway, Robert J; Fischer, Dawn A; de Abreu, Francine B et al. (2016) Genomic characterization of patient-derived xenograft models established from fine needle aspirate biopsies of a primary pancreatic ductal adenocarcinoma and from patient-matched metastatic sites. Oncotarget 7:17087-102
Liu, Yu-Chen; Li, Jian-Rong; Sun, Chuan-Hu et al. (2016) CircNet: a database of circular RNAs derived from transcriptome sequencing data. Nucleic Acids Res 44:D209-15

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