The Nuclear Magnetic Resonance (NMR) Shared Resource is a campus-wide facility with equal access by all Purdue University Center for Cancer Research investigators and operates under the Purdue University chargeback system. A centralized staff oversees the operation often mid- and high-field NMR spectrometers that range in field strengths from 300 MHz to 800 MHz. The spectrometers are located in four research buildings across the Purdue campus and are utilized in either a walk on or long term capacity for NMR analysis in synthetic chemistry and of biological systems. Management of this campus-wide facility by a single, expert staff facilitates the maintenance of the instruments while providing a cost-effective service to Cancer Center users.
The role of the shared resource is to assist individual investigators and scientific Programs within the Center that are seeking novel approaches to addressing a variety of cancer-related issues. In offering these key services, the shared resource provides the expertise necessary for achieving the next challenge;challenges that when solved will aid in reducing the pain and suffering of cancer.
|Onel, Buket; Carver, Megan; Agrawal, Prashansa et al. (2018) The 3'-end region of the human PDGFR-? core promoter nuclease hypersensitive element forms a mixture of two unique end-insertion G-quadruplexes. Biochim Biophys Acta Gen Subj 1862:846-854|
|Sorlien, Erin L; Witucki, Mary A; Ogas, Joseph (2018) Efficient Production and Identification of CRISPR/Cas9-generated Gene Knockouts in the Model System Danio rerio. J Vis Exp :|
|Mani, Saravana Kumar Kailasam; Andrisani, Ourania (2018) Interferon signaling during Hepatitis B Virus (HBV) infection and HBV-associated hepatocellular carcinoma. Cytokine :|
|Dong, Cheng; Dong, Guangping; Li, Li et al. (2018) An asparagine/glycine switch governs product specificity of human N-terminal methyltransferase NTMT2. Commun Biol 1:183|
|Morman, Rosemary E; Schweickert, Patrick G; Konieczny, Stephen F et al. (2018) BATF regulates the expression of Nfil3, Wnt10a and miR155hg for efficient induction of antibody class switch recombination in mice. Eur J Immunol 48:1492-1505|
|Zhang, Zhuangzhuang; Cheng, Lijun; Li, Jie et al. (2018) Inhibition of the Wnt/?-Catenin Pathway Overcomes Resistance to Enzalutamide in Castration-Resistant Prostate Cancer. Cancer Res 78:3147-3162|
|Rangasamy, Loganathan; Chelvam, Venkatesh; Kanduluru, Ananda Kumar et al. (2018) New Mechanism for Release of Endosomal Contents: Osmotic Lysis via Nigericin-Mediated K+/H+ Exchange. Bioconjug Chem 29:1047-1059|
|Zhang, Hao; Zhang, Yanqiu; Zhu, Xiaoyun et al. (2018) DEAD Box Protein 5 Inhibits Liver Tumorigenesis by Stimulating Autophagy via Interaction with p62/SQSTM1. Hepatology :|
|Lee, Hyeon Jeong; Li, Jie; Vickman, Renee E et al. (2018) Cholesterol Esterification Inhibition Suppresses Prostate Cancer Metastasis by Impairing the Wnt/?-catenin Pathway. Mol Cancer Res 16:974-985|
|Bhandari, Pushpak; Novikova, Gloriia; Goergen, Craig J et al. (2018) Ultrasound beam steering of oxygen nanobubbles for enhanced bladder cancer therapy. Sci Rep 8:3112|
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