Developmental funds will be used to provide startup funds for the recruitment of outstanding scientists to Purdue and to support the development of a new drug discovery shared resource. Molecular Discovery and Evaluation (MDE). Support of faculty recruitment focuses on adding faculty whose research interests represent strategic additions to the Center. These funds are intended to assist in providing newly recruited faculty members with the resources to establish their research programs and attract independent research support. The Center is involved in joint recruitments with key Departments on campus to enhance cancerfocused research at Purdue University. Currently, four such recruitments are in progress. The Center strategic plan includes enhancing research and shared resource strengths of the Center through faculty recruitment. Thus, ample the recruitment of additional new faculty will be vigorously pursued over the next five years. Support for the development of the MDE share resource will provide needed expansion of drug development services. The MDE will expand and automate previous drug discovery services provided by the Purdue University Center for Cancer Research. The primary mission of the MDE developmental shared resource is to enhance the capacity of the Purdue University Center for Cancer Research to accelerate therapeutic development including targeted agents. Funds are sought to partially support the development of the shared resource.
; Development funds are used by leadership to recruit new and talented investigators to the Center. Their recruitment brings in new expertise that enhances discovery and broadens collaborative efforts. New discoveries lead to new approaches for reducing the pain and suffering caused by cancer.
|Krisenko, Mariya O; Cartagena, Alexander; Raman, Arvind et al. (2015) Nanomechanical property maps of breast cancer cells as determined by multiharmonic atomic force microscopy reveal Syk-dependent changes in microtubule stability mediated by MAP1B. Biochemistry 54:60-8|
|Cho, Eun Jung; Sun, Bo; Doh, Kyung-Oh et al. (2015) Intraperitoneal delivery of platinum with in-situ crosslinkable hyaluronic acid gel for local therapy of ovarian cancer. Biomaterials 37:312-9|
|Bai, Yu; Davis, Dexter C; Dai, Mingji (2014) Synthesis of tetrahydropyran/tetrahydrofuran-containing macrolides by palladium-catalyzed alkoxycarbonylative macrolactonizations. Angew Chem Int Ed Engl 53:6519-22|
|Chao, Chi-Hong; Chang, Chao-Ching; Wu, Meng-Ju et al. (2014) MicroRNA-205 signaling regulates mammary stem cell fate and tumorigenesis. J Clin Invest 124:3093-106|
|Lee, Kyuwan; Cui, Yi; Lee, Luke P et al. (2014) Quantitative imaging of single mRNA splice variants in living cells. Nat Nanotechnol 9:474-80|
|Yang, Yang; Haskins, Christopher W; Zhang, Wandi et al. (2014) Divergent total syntheses of lyconadins A and C. Angew Chem Int Ed Engl 53:3922-5|
|Ghosh, Arun K; Osswald, Heather L (2014) BACE1 (?-secretase) inhibitors for the treatment of Alzheimer's disease. Chem Soc Rev 43:6765-813|
|Byun, Alexander J; Hung, Kenneth E; Fleet, James C et al. (2014) Colon-specific tumorigenesis in mice driven by Cre-mediated inactivation of Apc and activation of mutant Kras. Cancer Lett 347:191-5|
|Emmert, Dana; Campos, Christopher R; Ward, David et al. (2014) Reversible dimers of the atypical antipsychotic quetiapine inhibit p-glycoprotein-mediated efflux in vitro with increased binding affinity and in situ at the blood-brain barrier. ACS Chem Neurosci 5:305-17|
|Hrycyna, Christine A; Summers, Robert L; Lehane, Adele M et al. (2014) Quinine dimers are potent inhibitors of the Plasmodium falciparum chloroquine resistance transporter and are active against quinoline-resistant P. falciparum. ACS Chem Biol 9:722-30|
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