Developmental funds will be used to provide startup funds for the recruitment of outstanding scientists to Purdue and to support the development of a new drug discovery shared resource. Molecular Discovery and Evaluation (MDE). Support of faculty recruitment focuses on adding faculty whose research interests represent strategic additions to the Center. These funds are intended to assist in providing newly recruited faculty members with the resources to establish their research programs and attract independent research support. The Center is involved in joint recruitments with key Departments on campus to enhance cancerfocused research at Purdue University. Currently, four such recruitments are in progress. The Center strategic plan includes enhancing research and shared resource strengths of the Center through faculty recruitment. Thus, ample the recruitment of additional new faculty will be vigorously pursued over the next five years. Support for the development of the MDE share resource will provide needed expansion of drug development services. The MDE will expand and automate previous drug discovery services provided by the Purdue University Center for Cancer Research. The primary mission of the MDE developmental shared resource is to enhance the capacity of the Purdue University Center for Cancer Research to accelerate therapeutic development including targeted agents. Funds are sought to partially support the development of the shared resource.

Public Health Relevance

; Development funds are used by leadership to recruit new and talented investigators to the Center. Their recruitment brings in new expertise that enhances discovery and broadens collaborative efforts. New discoveries lead to new approaches for reducing the pain and suffering caused by cancer.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA023168-34
Application #
8681173
Study Section
Subcommittee B - Comprehensiveness (NCI)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
34
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Purdue University
Department
Type
DUNS #
City
West Lafayette
State
IN
Country
United States
Zip Code
47907
Huang, Xinxin; Guo, Bin; Liu, Sheng et al. (2018) Neutralizing negative epigenetic regulation by HDAC5 enhances human haematopoietic stem cell homing and engraftment. Nat Commun 9:2741
Chambers, Andrea M; Lupo, Kyle B; Matosevic, Sandro (2018) Tumor Microenvironment-Induced Immunometabolic Reprogramming of Natural Killer Cells. Front Immunol 9:2517
Shinde, Aparna; Wilmanski, Tomasz; Chen, Hao et al. (2018) Pyruvate carboxylase supports the pulmonary tropism of metastatic breast cancer. Breast Cancer Res 20:76
Nenortas, Nathaniel P; Cinelli, Maris A; Morrell, Andrew E et al. (2018) Activity of Aromathecins against African Trypanosomes. Antimicrob Agents Chemother 62:
Norvil, Allison B; Petell, Christopher J; Alabdi, Lama et al. (2018) Dnmt3b Methylates DNA by a Noncooperative Mechanism, and Its Activity Is Unaffected by Manipulations at the Predicted Dimer Interface. Biochemistry 57:4312-4324
Chambers, Andrea M; Wang, Jiao; Lupo, Kyle B et al. (2018) Adenosinergic Signaling Alters Natural Killer Cell Functional Responses. Front Immunol 9:2533
Serratore, Nina D; Baker, Kortany M; Macadlo, Lauren A et al. (2018) A Novel Sterol-Signaling Pathway Governs Azole Antifungal Drug Resistance and Hypoxic Gene Repression in Saccharomyces cerevisiae. Genetics 208:1037-1055
Wu, Heng; Post, Carol Beth (2018) Protein Conformational Transitions from All-Atom Adaptively Biased Path Optimization. J Chem Theory Comput 14:5372-5382
Denton, Kyle E; Wang, Sijie; Gignac, Michael C et al. (2018) Robustness of In Vitro Selection Assays of DNA-Encoded Peptidomimetic Ligands to CBX7 and CBX8. SLAS Discov 23:417-428
Liu, Wenting; Zhong, Yi-Fang; Liu, Liu-Yi et al. (2018) Solution structures of multiple G-quadruplex complexes induced by a platinum(II)-based tripod reveal dynamic binding. Nat Commun 9:3496

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