The Jackson Laboratory Cancer Center (JAXCC) has undergone a major change in leadership with the recruitment of Edison Liu, MD in 2012 to serve as Director (4.8 months calendar effort). Robert Braun, PhD, serves as Deputy Director (2.4 calendar months). Dr. Liu, who is the President and CEO of JAX, was appointed by and reports to the JAX Board of Trustees. He sets the scientific direction and makes all appointments to the JAXCC. He has final authority on all budget decisions, and is responsible for the allocation of all central discretionary and philanthropic funds, space, and equipment for JAX and the JAXCC. Dr. Liu is a physician and researcher whose work on functional genomics of human cancers, particularly breast cancer spans the fields of molecular oncogenesis, epidemiology, genomics, and genetics. He has substantial leadership experience, most recently serving as Executive Director of the Genome Institute of Singapore, which he developed from its inception to an internationally recognized genome center. Dr. Braun, who is the Vice President for Research of JAX, reports to Dr. Liu and works closely with him to foster and implement strategic initiatives and appoint, develop and promote JAXCC members. He has primary responsibility for coordinating research across the 3 JAXCC campuses. Dr. Braun is an expert in male reproduction with a focus on RNA biology, adult stem cells and androgen action. Expansion of the Senior Leadership team was an immediate priority culminating in the appointment of additional senior leaders from the three JAXCC campuses to a Scientific Executive Committee (SEC) with Drs. Liu and Braun to guide the ongoing growth ofthe JAXCC, These include: Carol Bult, PhD, Chengkai Dai, MD, PhD, Neal Goodwin, PhD, Frank McKeon, PhD, Kevin Mills, PhD and Yijun Ruan, PhD. Drs, Bult, Dai and McKeon dedicate 1.2 calendar months to their roles as co-Program Leaders and serve the SEC in that capacity. Dr. Mills serves as Associate Director, Regional Translational Partnerships (1.2 calendar months), and leads the development of collaborative research with New England clinical centers. Dr. Goodwin, Senior Fellow, devotes 0.3 calendar months to integrating the PDX resource with the JAXCC research goals. Dr. Ruan (0.3 months effort) directs the genome technologies development initiative. The SEC meets monthly to plan large collaborative cancer research projects;coordinate and engage the JAXCC membership in the major technology and model development initiatives of the JAXCC;and direct the pilot project program in order to align research development with the strategic goals of the JAXCC. Strengthening translational outreach is a major goal. The senior leadership has formed collaborative relationships with regional cancer care centers in Maine and Connecticut, and has developed relationships with members of SWOG, culminating in membership as a Translational Medicine Member in 2013.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA034196-29
Application #
8699296
Study Section
Subcommittee G - Education (NCI)
Project Start
1997-08-01
Project End
2019-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
29
Fiscal Year
2014
Total Cost
$103,389
Indirect Cost
$44,310
Name
Jackson Laboratory
Department
Type
DUNS #
042140483
City
Bar Harbor
State
ME
Country
United States
Zip Code
04609
Wang, Qianghu; Hu, Baoli; Hu, Xin et al. (2017) Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment. Cancer Cell 32:42-56.e6
Herbert Pratt, C; Potter, Christopher S; Kuiper, Raoul V et al. (2017) Skin fragility in the wild-derived, inbred mouse strain Mus pahari/EiJ. Exp Mol Pathol 102:128-132
Burack, W Richard; Spence, Janice M; Spence, John P et al. (2017) Patient-derived xenografts of low-grade B-cell lymphomas demonstrate roles of the tumor microenvironment. Blood Adv 1:1263-1273
Hosur, Vishnu; Low, Benjamin E; Avery, Cindy et al. (2017) Development of Humanized Mice in the Age of Genome Editing. J Cell Biochem 118:3043-3048
Pratt, C Herbert; King Jr, Lloyd E; Messenger, Andrew G et al. (2017) Alopecia areata. Nat Rev Dis Primers 3:17011
Sutphin, George L; Backer, Grant; Sheehan, Susan et al. (2017) Caenorhabditis elegans orthologs of human genes differentially expressed with age are enriched for determinants of longevity. Aging Cell 16:672-682
Verma, Mohit K; Clemens, Julia; Burzenski, Lisa et al. (2017) A novel hemolytic complement-sufficient NSG mouse model supports studies of complement-mediated antitumor activity in vivo. J Immunol Methods 446:47-53
Kooreman, Nigel G; de Almeida, Patricia E; Stack, Jonathan P et al. (2017) Alloimmune Responses of Humanized Mice to Human Pluripotent Stem Cell Therapeutics. Cell Rep 20:1978-1990
Hosur, Vishnu; Burzenski, Lisa M; Stearns, Timothy M et al. (2017) Early induction of NRF2 antioxidant pathway by RHBDF2 mediates rapid cutaneous wound healing. Exp Mol Pathol 102:337-346
Hwang, Grace; Sun, Fengyun; O'Brien, Marilyn et al. (2017) SMC5/6 is required for the formation of segregation-competent bivalent chromosomes during meiosis I in mouse oocytes. Development 144:1648-1660

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