Abstract

The NMR Shared Resource provides the infrastructure for the acquisition of NMR data and the determination of structures of biological molecules. The Varian INOVA 500-MHz NMR magnet, with its new console and probes are located in room 1009 of the Eppley Science Hall. The new Varian INOVA 600-MHz instrument is in the adjacent room (1010 ESH) and the two rooms have been connected with an opening. The 500-MHz NMR instrument has been upgraded with a new console and associated probes to make it state-of-the-art and compatible with the 600 instrument. A cold probe has been ordered for the 600 instrument, which will provide a significant increase in signal to noise and sensitivity. The facility is directed by Dr. Gus Wang (Assistant Professor, Eppley Institute, UNMC), with the support of Paul Keifer, Ph.D. (Research Assistant Professor, Eppley Institute), who maintains the infrastructure and provides user support. Cancer Center members with peer-reviewed funding account for 18% of the facility's usage.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA036727-23
Application #
7484290
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2007-08-01
Budget End
2008-07-31
Support Year
23
Fiscal Year
2007
Total Cost
$96,428
Indirect Cost

  Institution

Name
University of Nebraska Medical Center
Department
Type
DUNS #
168559177
City
Omaha
State
NE
Country
United States
Zip Code
68198

  Publications

Won, Harim I; Schulze, Thomas T; Clement, Emalie J et al. (2018) De novo Assembly of the Burying Beetle Nicrophorus orbicollis (Coleoptera: Silphidae) Transcriptome Across Developmental Stages with Identification of Key Immune Transcripts. J Genomics 6:41-52
Zhou, Jiuli; Zeng, Yongji; Cui, Lian et al. (2018) Zyxin promotes colon cancer tumorigenesis in a mitotic phosphorylation-dependent manner and through CDK8-mediated YAP activation. Proc Natl Acad Sci U S A 115:E6760-E6769
Das, Binita; Neilsen, Beth K; Fisher, Kurt W et al. (2018) A Functional Signature Ontology (FUSION) screen detects an AMPK inhibitor with selective toxicity toward human colon tumor cells. Sci Rep 8:3770
Qazi, Asif Khurshid; Siddiqui, Jawed A; Jahan, Rahat et al. (2018) Emerging therapeutic potential of graviola and its constituents in cancers. Carcinogenesis 39:522-533
Hsu, Alice H; Lum, Michelle A; Shim, Kang-Sup et al. (2018) Crosstalk between PKC? and PI3K/AKT Signaling Is Tumor Suppressive in the Endometrium. Cell Rep 24:655-669
Svechkarev, Denis; Sadykov, Marat R; Bayles, Kenneth W et al. (2018) Ratiometric Fluorescent Sensor Array as a Versatile Tool for Bacterial Pathogen Identification and Analysis. ACS Sens 3:700-708
Contreras, Jacob I; Robb, Caroline M; King, Hannah M et al. (2018) Chemical Genetic Screens Identify Kinase Inhibitor Combinations that Target Anti-Apoptotic Proteins for Cancer Therapy. ACS Chem Biol 13:1148-1152
Qi, Bowen; Crawford, Ayrianne J; Wojtynek, Nicholas E et al. (2018) Indocyanine green loaded hyaluronan-derived nanoparticles for fluorescence-enhanced surgical imaging of pancreatic cancer. Nanomedicine 14:769-780
Berger, Ann M; Kupzyk, Kevin A; Djalilova, Dilorom M et al. (2018) Breast Cancer Collaborative Registry informs understanding of factors predicting sleep quality. Support Care Cancer :
Svechkarev, Denis; Mohs, Aaron M (2018) Organic fluorescent dye-based nanomaterials: Advances in the rational design for imaging and sensing applications. Curr Med Chem :

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