The Staff Investigator Position of this application was assembled with the specific intention to formalize and expand the activities of an important Huntsman Cancer Institute (HCI) investigator. Dr. Lisa Cannon- Albright. A summary of Dr. Cannon-Albright's qualifications and activities is provided below. The activities proposed contribute specifically to our Cancer Center goal of maximizing achievement in individualized oncology. Dr. Cannon-Albright extensively utilizes our unique resource, the Utah Population Database (UPDB), the only database of its kind in the United States and one of few such resources in the worid. This is a rich source of information for genetic, epidemiological, demographic, and public health studies. Such discoveries have implications for translation regarding individualized cancer susceptibility testing and appropriate surveillance; individual cancer treatment responses for planning optimal therapies; and, identification of targets of intervention for suggesting novel therapies tailored to the individual. Through cancer susceptibility chromosomal loci and gene identification, the Staff Investigator will initiate translational and transdisciplinary investigations characterized by the following: 1) Cooperation between high-risk cancer populations and clinicians focused on prevention and patient care. 2) Development of preclinical models of disease through interactions among clinical trial researchers 3) Interactions between basic scientists interested in genomics and signaling pathways and investigators focused on high-risk populations and clinical trial development. 4) Collaborations among genetic epidemiologists, basic scientists, and clinical prevention specialists.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
3P30CA042014-23S1
Application #
8533382
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2012-05-01
Budget End
2013-04-30
Support Year
23
Fiscal Year
2012
Total Cost
$3,410
Indirect Cost
$1,129
Name
University of Utah
Department
Type
DUNS #
009095365
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
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Affolter, Kajsa; Gligorich, Keith; Samadder, Niloy Jewel et al. (2017) Feasibility of Large-Scale Identification of Sessile Serrated Polyp Patients Using Electronic Records: A Utah Study. Dig Dis Sci 62:1455-1463
Fowler, Brynn; Samadder, N Jewel; Kepka, Deanna et al. (2017) Improvements in Colorectal Cancer Incidence Not Experienced by Nonmetropolitan Women: A Population-Based Study From Utah. J Rural Health :
Ou, Judy Y; Smits-Seemann, Rochelle R; Kaul, Sapna et al. (2017) Risk of hospitalization among survivors of childhood and adolescent acute lymphoblastic leukemia compared to siblings and a general population sample. Cancer Epidemiol 49:216-224
VanderLinden, Ryan T; Hemmis, Casey W; Yao, Tingting et al. (2017) Structure and energetics of pairwise interactions between proteasome subunits RPN2, RPN13, and ubiquitin clarify a substrate recruitment mechanism. J Biol Chem 292:9493-9504
Cohen, Adam L; Factor, Rachel E; Mooney, Kathi et al. (2017) POWERPIINC (PreOperative Window of Endocrine TheRapy Provides Information to Increase Compliance) trial: Changes in tumor proliferation index and quality of life with 7 days of preoperative tamoxifen. Breast 31:219-223
Gardiner, Jamie D; Abegglen, Lisa M; Huang, Xiaomeng et al. (2017) C/EBP?-1 promotes transformation and chemoresistance in Ewing sarcoma cells. Oncotarget 8:26013-26026
Ding, Yun; Fleming, Aaron M; Burrows, Cynthia J (2017) Sequencing the Mouse Genome for the Oxidatively Modified Base 8-Oxo-7,8-dihydroguanine by OG-Seq. J Am Chem Soc 139:2569-2572
Carleton, Julia B; Berrett, Kristofer C; Gertz, Jason (2017) Multiplex Enhancer Interference Reveals Collaborative Control of Gene Regulation by Estrogen Receptor ?-Bound Enhancers. Cell Syst 5:333-344.e5
Lai, Run-Zhi; Han, Xue-Sheng; Dahlquist, Frederick W et al. (2017) Paradoxical enhancement of chemoreceptor detection sensitivity by a sensory adaptation enzyme. Proc Natl Acad Sci U S A 114:E7583-E7591

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