The Huntsman Cancer Institute (HCI) Tissue Resource and Applications Core (TRAC) Shared Resource supports Cancer Center members by collecting, storing, tracking, processing, and distributing human tissue biospecimens. TRAC currently tracks more than 30,000 specimens through a Biospecimen Tracking (BST) Database, which links important clinical and pathological information with collected specimens. The vast majority of cancer patients (>90%) undergoing surgery at HCI consent to donate tissue and blood for research purposes. The mission of the TRAC is to provide high-quality, clinically annotated specimens and superior service to the broad University of Utah (U of U) research community. Cancer specimens of all types are collected by TRAC under IRB #10924 Molecular Classifications of Cancer. This protocol was established to streamline the process of collecting, tracking, and utilizing cancer biospecimens for researchers at the U of U. Collection of fresh tissue for research is a TRAC priority. On average, TRAC procures approximately 20 percent of tissues as fresh frozen. In addition, clinical specimens, archived as formalin-fixed, paraffin-embedded tissue, are readily accessible for research from the Pathology Department on all consented patients. Samples collected by TRAC primarily come from within the U of U;however, protocols are in place for collection of specimens at other hospitals within the greater Salt Lake City area. Our IRB protocol is linked to several clinical and research databases at the U of U, including the Data Warehouse, the Tumor Registry, and the Utah Population Database. Thus, the integrity and accuracy of clinical data associated with specimens collected by the Resource are ensured by established quality-control measures. The TRAC is directed by Ann Georgelas Cline, MS. Duties of the Shared Resource are set by a Faculty Advisory Committee co-chaired by Philip Bernard, MD, and Joshua Schiffman, MD. The committee is composed of Cancer Center members who represent seven different departments at the U of U. The committee is charged with defining TRAC services as well as tissue collection and use policies to support the Cancer Center mission. The TRAC Shared Resource is a Cancer Center-managed facility with supervision from HCI Directors;a survey has assessed user satisfaction. In 2008, use of the TRAC Shared Resource by Cancer Center members averaged 75 percent. Funds are requested from the CCSG to cover 10 percent ($52,810) of the proposed Resource budget. The TRAC Shared Resource has ample capacity for additional use by Cancer Center members.

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National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee G - Education (NCI)
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University of Utah
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Fuller, Andrew K; Bice, Benjamin D; Venancio, Ashlee R et al. (2018) A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model. J Vis Exp :
Wang, Sophia S; Carrington, Mary; Berndt, Sonja I et al. (2018) HLA Class I and II Diversity Contributes to the Etiologic Heterogeneity of Non-Hodgkin Lymphoma Subtypes. Cancer Res 78:4086-4096
Faham, Najme; Zhao, Ling; Welm, Alana L (2018) mTORC1 is a key mediator of RON-dependent breast cancer metastasis with therapeutic potential. NPJ Breast Cancer 4:36
Rengifo-Cam, William; Shepherd, Hailey M; Jasperson, Kory W et al. (2018) Colon Pathology Characteristics in Li-Fraumeni Syndrome. Clin Gastroenterol Hepatol 16:140-141
Solomon, Benjamin L; Garrido-Laguna, Ignacio (2018) Upper gastrointestinal malignancies in 2017: current perspectives and future approaches. Future Oncol 14:947-962
Gaffney, David K; Hashibe, Mia; Kepka, Deanna et al. (2018) Too many women are dying from cervix cancer: Problems and solutions. Gynecol Oncol 151:547-554
Hardy, Christopher M; Burke, Molly K; Everett, Logan J et al. (2018) Genome-Wide Analysis of Starvation-Selected Drosophila melanogaster-A Genetic Model of Obesity. Mol Biol Evol 35:50-65
Gilcrease, Eddie B; Casjens, Sherwood R (2018) The genome sequence of Escherichia coli tailed phage D6 and the diversity of Enterobacteriales circular plasmid prophages. Virology 515:203-214
Park, Jihye; Blackburn, Brenna E; Rowe, Kerry et al. (2018) Rural-metropolitan disparities in ovarian cancer survival: a statewide population-based study. Ann Epidemiol 28:377-384
Fowler, Brynn; Ding, Qian; Pappas, Lisa et al. (2018) Utah Cancer Survivors: A Comprehensive Comparison of Health-Related Outcomes Between Survivors and Individuals Without a History of Cancer. J Cancer Educ 33:214-221

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