The Huntsman Cancer Institute (HCI) Tissue Resource and Applications Core (TRAC) Shared Resource supports Cancer Center members by collecting, storing, tracking, processing, and distributing human tissue biospecimens. TRAC currently tracks more than 30,000 specimens through a Biospecimen Tracking (BST) Database, which links important clinical and pathological information with collected specimens. The vast majority of cancer patients (>90%) undergoing surgery at HCI consent to donate tissue and blood for research purposes. The mission of the TRAC is to provide high-quality, clinically annotated specimens and superior service to the broad University of Utah (U of U) research community. Cancer specimens of all types are collected by TRAC under IRB #10924 Molecular Classifications of Cancer. This protocol was established to streamline the process of collecting, tracking, and utilizing cancer biospecimens for researchers at the U of U. Collection of fresh tissue for research is a TRAC priority. On average, TRAC procures approximately 20 percent of tissues as fresh frozen. In addition, clinical specimens, archived as formalin-fixed, paraffin-embedded tissue, are readily accessible for research from the Pathology Department on all consented patients. Samples collected by TRAC primarily come from within the U of U;however, protocols are in place for collection of specimens at other hospitals within the greater Salt Lake City area. Our IRB protocol is linked to several clinical and research databases at the U of U, including the Data Warehouse, the Tumor Registry, and the Utah Population Database. Thus, the integrity and accuracy of clinical data associated with specimens collected by the Resource are ensured by established quality-control measures. The TRAC is directed by Ann Georgelas Cline, MS. Duties of the Shared Resource are set by a Faculty Advisory Committee co-chaired by Philip Bernard, MD, and Joshua Schiffman, MD. The committee is composed of Cancer Center members who represent seven different departments at the U of U. The committee is charged with defining TRAC services as well as tissue collection and use policies to support the Cancer Center mission. The TRAC Shared Resource is a Cancer Center-managed facility with supervision from HCI Directors;a survey has assessed user satisfaction. In 2008, use of the TRAC Shared Resource by Cancer Center members averaged 75 percent. Funds are requested from the CCSG to cover 10 percent ($52,810) of the proposed Resource budget. The TRAC Shared Resource has ample capacity for additional use by Cancer Center members.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA042014-24
Application #
8465121
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
24
Fiscal Year
2013
Total Cost
$52,561
Indirect Cost
$21,826
Name
University of Utah
Department
Type
DUNS #
009095365
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
Warner, Echo L; Ding, Qian; Pappas, Lisa et al. (2017) Health Care Providers' Knowledge of HPV Vaccination, Barriers, and Strategies in a State With Low HPV Vaccine Receipt: Mixed-Methods Study. JMIR Cancer 3:e12
Affolter, Kajsa; Gligorich, Keith; Samadder, Niloy Jewel et al. (2017) Feasibility of Large-Scale Identification of Sessile Serrated Polyp Patients Using Electronic Records: A Utah Study. Dig Dis Sci 62:1455-1463
Fowler, Brynn; Samadder, N Jewel; Kepka, Deanna et al. (2017) Improvements in Colorectal Cancer Incidence Not Experienced by Nonmetropolitan Women: A Population-Based Study From Utah. J Rural Health :
Ou, Judy Y; Smits-Seemann, Rochelle R; Kaul, Sapna et al. (2017) Risk of hospitalization among survivors of childhood and adolescent acute lymphoblastic leukemia compared to siblings and a general population sample. Cancer Epidemiol 49:216-224
VanderLinden, Ryan T; Hemmis, Casey W; Yao, Tingting et al. (2017) Structure and energetics of pairwise interactions between proteasome subunits RPN2, RPN13, and ubiquitin clarify a substrate recruitment mechanism. J Biol Chem 292:9493-9504
Cohen, Adam L; Factor, Rachel E; Mooney, Kathi et al. (2017) POWERPIINC (PreOperative Window of Endocrine TheRapy Provides Information to Increase Compliance) trial: Changes in tumor proliferation index and quality of life with 7 days of preoperative tamoxifen. Breast 31:219-223
Gardiner, Jamie D; Abegglen, Lisa M; Huang, Xiaomeng et al. (2017) C/EBP?-1 promotes transformation and chemoresistance in Ewing sarcoma cells. Oncotarget 8:26013-26026
Ding, Yun; Fleming, Aaron M; Burrows, Cynthia J (2017) Sequencing the Mouse Genome for the Oxidatively Modified Base 8-Oxo-7,8-dihydroguanine by OG-Seq. J Am Chem Soc 139:2569-2572
Carleton, Julia B; Berrett, Kristofer C; Gertz, Jason (2017) Multiplex Enhancer Interference Reveals Collaborative Control of Gene Regulation by Estrogen Receptor ?-Bound Enhancers. Cell Syst 5:333-344.e5
Lai, Run-Zhi; Han, Xue-Sheng; Dahlquist, Frederick W et al. (2017) Paradoxical enhancement of chemoreceptor detection sensitivity by a sensory adaptation enzyme. Proc Natl Acad Sci U S A 114:E7583-E7591

Showing the most recent 10 out of 1113 publications