Hematopoietic Stem Cell Core Program Director/Principal Investigator: Gerson, Stanton L. PROJECT SUMMARY (See Instmctions): The Case CCC Hematopoietic Stem Cell Core provides for the procurement, processing, production. Storage, banking, analysis and distribution of cells derived from human blood, bone marrow, and umbilical cords. The Core is composed of two components: 1) A human hematopoietic biorepository and support services to facilitate basic hematopoietic research, and 2) A cellular therapy facility that supports clinical grade cell manufacturing for investigational and standard-of-care therapy. The biorepository procures, processes, banks and distributes human cells from a variety of sources for researchers under an Institutional Review Board (IRB)-approved protocol. This facility obviates the need for Cancer Center members to invest in specialized stem cell reagents and procedures as well as the need to identify and procure blood or bone marrow samples from normal donors and patients with specific hematologic disorders The cellular therapy component of the Core, designated as the Cellular Therapy Service, supports clinical cellular therapy activities from the preclinical phase through clinical trial implementation. While the heaviest use of the Core is by members of the Hematopoietic Disorders Program, the Core has supported work in 6 of the 8 Research Programs of the Cancer Center. In particular, the Core supported work that: investigated the efficacy of novel leukemia therapeutics identified on human AML patient samples as well as determining their myelotoxic effects on normal bone marrow;identified that the combination of fludarabine plus MX represents a potential new clinical targeted therapy;and uses human MSCs to devise a novel model on the trophic and immunomodulatory properties of MSCs that may have important implications in cancer.
The Case Comprehensive Cancer Center is Northeast Ohio's only NCI designated comprehensive cancer center providing bench-to-bedside medical research involving partnerships between basic, clinical and population scientists to speed translation of laboratory discoveries into new prevention/intervention and cancer treatments.
|Levinson, Kimberly L; Jernigan, Amelia M; Flocke, Susan A et al. (2016) Intimate Partner Violence and Barriers to Cervical Cancer Screening: A Gynecologic Oncology Fellow Research Network Study. J Low Genit Tract Dis 20:47-51|
|Cooper, Gregory S; Kou, Tzuyung D; Schluchter, Mark D et al. (2016) Changes in Receipt of Cancer Screening in Medicare Beneficiaries Following the Affordable Care Act. J Natl Cancer Inst 108:|
|Wiechert, Andrew; Saygin, Caner; Thiagarajan, Praveena S et al. (2016) Cisplatin induces stemness in ovarian cancer. Oncotarget 7:30511-22|
|Somasegar, Sahana; Li, Li; Thompson, Cheryl L (2016) No association of reproductive risk factors with breast cancer tumor grade. Eur J Cancer Prev :|
|Kenyon, Jonathan; Nickel-Meester, Gabrielle; Qing, Yulan et al. (2016) Epigenetic Loss of MLH1 Expression in Normal Human Hematopoietic Stem Cell Clones is Defined by the Promoter CpG Methylation Pattern Observed by High-Throughput Methylation Specific Sequencing. Int J Stem Cell Res Ther 3:|
|Dowlati, A; Lipka, M B; McColl, K et al. (2016) Clinical correlation of extensive-stage small-cell lung cancer genomics. Ann Oncol 27:642-7|
|Markowitz, Sanford D; Nock, Nora L; Schmit, Stephanie L et al. (2016) A Germline Variant on Chromosome 4q31.1 Associates with Susceptibility to Developing Colon Cancer Metastasis. PLoS One 11:e0146435|
|Wang, Y; Deng, O; Feng, Z et al. (2016) RNF126 promotes homologous recombination via regulation of E2F1-mediated BRCA1 expression. Oncogene 35:1363-72|
|Doherty, Mary R; Smigiel, Jacob M; Junk, Damian J et al. (2016) Cancer Stem Cell Plasticity Drives Therapeutic Resistance. Cancers (Basel) 8:|
|Blum, Andrew E; Venkitachalam, Srividya; Guo, Yan et al. (2016) RNA Sequencing Identifies Transcriptionally Viable Gene Fusions in Esophageal Adenocarcinomas. Cancer Res 76:5628-5633|
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