Detailed understanding of molecular function in biological systems requires information about the 3D structures of macromolecules. The wealth of information available from such studies provides novel and powerful insights into function. Chemical biology, the modulation of protein function by small molecules, provides tool compounds to explore biological function as well as novel therapeutics for the clinic. The tools of imaging, detection, and drug delivery emerge from chemical biology efforts. The merging of the structural biology and chemical biology faculty brings together two groups that speak the same language, the language of molecular structure, making this a natural grouping. The overarching goal of the Chemical & Structural Biology (CSB) Program is to facilitate this dialogue in ways that accelerate understanding, detection, and treatment of cancer. The Program leader is John H. Bushweller, PhD, Professor of Molecular Physiology and Biological Physics, and the co-leader is Kevin R. Lynch, PhD, Professor of Pharmacology and Biochemistry & Molecular Genetics. The Program currently consists of 23 members and 6 associate members from seven different departments spanning three different schools at UVA. This includes the Chemistry Department, providing unique cross- campus opportunities to bring the power of chemistry to bear on cancer. Six of these individuals were recruited to UVA since the last renewal. Total extramural funding for the Program exceeds $12M, including over $2.4M from the NCI and over $8.7M from other NIH institutes. The group members rely heavily on Cancer Center supported infrastructure, particularly the Biomolecular Analysis Core and NMR instrumentation. Pilot grant support of CSB members has shown a clear return on investment with several NCI funded grants emerging from work supported originally with pilot grant support. The many activities and interactions have led to 276 publications, of which 18% were inter-programmatic publications and 18% were intra-programmatic publications since the last renewal.

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National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee I - Transistion to Independence (NCI)
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University of Virginia
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Melssen, Marit; Slingluff Jr, Craig L (2017) Vaccines targeting helper T cells for cancer immunotherapy. Curr Opin Immunol 47:85-92
Bullock, Timothy Nj (2017) TNF-receptor superfamily agonists as molecular adjuvants for cancer vaccines. Curr Opin Immunol 47:70-77
Scalici, Jennifer M; Arapovic, Sanja; Saks, Erin J et al. (2017) Mesothelium expression of vascular cell adhesion molecule-1 (VCAM-1) is associated with an unfavorable prognosis in epithelial ovarian cancer (EOC). Cancer 123:977-984
Shukla, Girja S; Olson, Walter C; Pero, Stephanie C et al. (2017) Vaccine-draining lymph nodes of cancer patients for generating anti-cancer antibodies. J Transl Med 15:180
Keim-Malpass, Jessica; Mitchell, Emma M; DeGuzman, Pamela B et al. (2017) Legislative activity related to the human papillomavirus (HPV) vaccine in the United States (2006-2015): a need for evidence-based policy. Risk Manag Healthc Policy 10:29-32
Mills, Anne M; Paquette, Cherie; Terzic, Tatjana et al. (2017) CK7 Immunohistochemistry as a Predictor of CIN1 Progression: A Retrospective Study of Patients From the Quadrivalent HPV Vaccine Trials. Am J Surg Pathol 41:143-152
Rohani, Ali; Moore, John H; Kashatus, Jennifer A et al. (2017) Label-Free Quantification of Intracellular Mitochondrial Dynamics Using Dielectrophoresis. Anal Chem 89:5757-5764
Wages, N A; Slingluff Jr, C L; Petroni, G R (2017) Statistical controversies in clinical research: early-phase adaptive design for combination immunotherapies. Ann Oncol 28:696-701
O'Brien, Carleigh A; Overall, Christopher; Konradt, Christoph et al. (2017) CD11c-Expressing Cells Affect Regulatory T Cell Behavior in the Meninges during Central Nervous System Infection. J Immunol 198:4054-4061
Bullock, Timothy Nj (2017) Stimulating CD27 to quantitatively and qualitatively shape adaptive immunity to cancer. Curr Opin Immunol 45:82-88

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