For more than thirty years, the Flow Cytometry Shared Resource has served members of the CSHL Cancer Center, offering access to critical equipment and expertise for cell sorting and cell population analysis. The Shared Resource offers three different state-of-the-art instruments with up to five different lasers for cell sorting and analysis. Expert staff is also available for training in the use of equipment, consultation on experimental design, and assistance with operation of instruments. All of these services are highly technical and require skilled staff. Access to Flow Cytometry has allowed the development of protocols for single cell sequencing, the generation and analysis of innovative animal models, and isolation and characterization of the stem cells and immune cells involved in cancer. The Flow Cytometry Shared Resource is well used by Cancer Center members; 31 members (84% of the membership) used this Shared Resource, accounting for 95% of use. Without the Flow Cytometry Shared Resource it would be extremely difficult for individual investigators to have access to this sophisticated instrumentation and these types of services, which are critical to their research programs. During the last funding period, the laboratory space for the Flow Cytometry Shared Resource has been renovated and expanded, improving the efficiency and reliability of the Shared Resource. In summary, the Shared Resource provides CSHL Cancer Center members with a complete complement of state-of-the-art instrumentation and advanced technical support to help accelerate cancer research and discovery.
Arun, Gayatri; Diermeier, Sarah D; Spector, David L (2018) Therapeutic Targeting of Long Non-Coding RNAs in Cancer. Trends Mol Med 24:257-277 |
Giuliano, Christopher J; Lin, Ann; Smith, Joan C et al. (2018) MELK expression correlates with tumor mitotic activity but is not required for cancer growth. Elife 7: |
Li, Jiahe; Wu, Connie; Wang, Wade et al. (2018) Structurally modulated codelivery of siRNA and Argonaute 2 for enhanced RNA interference. Proc Natl Acad Sci U S A 115:E2696-E2705 |
Tarumoto, Yusuke; Lu, Bin; Somerville, Tim D D et al. (2018) LKB1, Salt-Inducible Kinases, and MEF2C Are Linked Dependencies in Acute Myeloid Leukemia. Mol Cell 69:1017-1027.e6 |
Krishnan, Navasona; Konidaris, Konstantis F; Gasser, Gilles et al. (2018) A potent, selective, and orally bioavailable inhibitor of the protein-tyrosine phosphatase PTP1B improves insulin and leptin signaling in animal models. J Biol Chem 293:1517-1525 |
Borges, Filipe; Parent, Jean-Sébastien; van Ex, Frédéric et al. (2018) Transposon-derived small RNAs triggered by miR845 mediate genome dosage response in Arabidopsis. Nat Genet 50:186-192 |
Chen, Xiaoyin; Sun, Yu-Chi; Church, George M et al. (2018) Efficient in situ barcode sequencing using padlock probe-based BaristaSeq. Nucleic Acids Res 46:e22 |
Tonelli, Claudia; Chio, Iok In Christine; Tuveson, David A (2018) Transcriptional Regulation by Nrf2. Antioxid Redox Signal 29:1727-1745 |
Kumar, Vijay; Rosenbaum, Julie; Wang, Zihua et al. (2018) Partial bisulfite conversion for unique template sequencing. Nucleic Acids Res 46:e10 |
Lee, Je H (2018) Tracing single-cell histories. Science 359:521-522 |
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