The Radiation Sciences Program brings together laboratory and clinical investigators and clinicians Interested in the biological effects of radiation and the use of radiation therapy for cancer treatment. The program consists of 26 members from 8 different departments. Since the last funding cycle the research base for the Radiation Sciences Program increased 48% from $4,142,697 to $6,112,068 total annual direct research support, of which $4,065,571 is from the NCI. Over this last grant period, there were 278 publications of Radiation Science Program members, of which 18.7% are intra-programmatic and 44.2% are inter-programmatic. The members are divided into two chief interest groups: The biology interest group consists of investigators studying basic mechanisms of how cells respond to DNIA-damaging agents. A better understanding of these fundamental basic mechanisms in normal and cancer cells is critical in guiding the development of improved use of radiation in the clinic. Some of the specific areas studied by members of this interest group Include: Induction of DNA damage;mechanisms of DNA double strand break repair;regulation of DNA damage signal transduction;activation of cell cycle checkpoints;mechanisms of DNA damage-induced cell death;gene therapy for cancer treatment;molecular targets of radiosensitization;DNA damage-induced gene expression;mechanism of replication stress in cancer cells;and, genomic instability. The medical physics Interest group consists of investigators applying physics to the practice of radiation oncology. This group has a long track record of developing novel highly conformal radiation therapy techniques. This group has strong interactions with many clinical programs in the Cancer Center including Head and Neck, GI, Lung, Breast, and Prostate. In addition, this group has worked with clinicians in neuro-oncology and with the Molecular Imaging Program to develop new methods of functional imaging in the CNS. Specific topics of Interest include developing new methods of: dose calculation;optimization;assessment and correction of geometric uncertainties;image registration;constructing 4-D models of patients for planning;treatment delivery;and, imaging patients or tumors in real time during treatment.
The research undertaken by the members of the Radiation Sciences Program are of significant relevance to public health both for the understanding of the human health threats of radiation exposure as well as for improved uses of radiation in cancer treatment.
|Verhaegen, Monique E; Mangelberger, Doris; Harms, Paul W et al. (2015) Merkel cell polyomavirus small T antigen is oncogenic in transgenic mice. J Invest Dermatol 135:1415-24|
|Chinn, Steven B; Darr, Owen A; Owen, John H et al. (2015) Cancer stem cells: mediators of tumorigenesis and metastasis in head and neck squamous cell carcinoma. Head Neck 37:317-26|
|Vainshtein, Jeffrey M; Spector, Matthew E; Stenmark, Matthew H et al. (2014) Reliability of post-chemoradiotherapy F-18-FDG PET/CT for prediction of locoregional failure in human papillomavirus-associated oropharyngeal cancer. Oral Oncol 50:234-9|
|Castro, Maria G; Candolfi, Marianela; Wilson, Thomas J et al. (2014) Adenoviral vector-mediated gene therapy for gliomas: coming of age. Expert Opin Biol Ther 14:1241-57|
|Vainshtein, Jeffrey M; Spector, Matthew E; McHugh, Jonathan B et al. (2014) Refining risk stratification for locoregional failure after chemoradiotherapy in human papillomavirus-associated oropharyngeal cancer. Oral Oncol 50:513-9|
|Grogan, Patrick T; Sarkaria, Jann N; Timmermann, Barbara N et al. (2014) Oxidative cytotoxic agent withaferin A resensitizes temozolomide-resistant glioblastomas via MGMT depletion and induces apoptosis through Akt/mTOR pathway inhibitory modulation. Invest New Drugs 32:604-17|
|VanderVeen, Nathan; Paran, Christopher; Appelhans, Ashley et al. (2014) Marmosets as a preclinical model for testing "off-label" use of doxycycline to turn on Flt3L expression from high-capacity adenovirus vectors. Mol Ther Methods Clin Dev 1:|
|Krook, Melanie A; Nicholls, Lauren A; Scannell, Christopher A et al. (2014) Stress-induced CXCR4 promotes migration and invasion of ewing sarcoma. Mol Cancer Res 12:953-64|
|Ro, Seung-Hyun; Semple, Ian A; Park, Haewon et al. (2014) Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1. FEBS J 281:3816-27|
|Stenmark, Matthew H; McHugh, Jonathan B; Schipper, Matthew et al. (2014) Nonendemic HPV-positive nasopharyngeal carcinoma: association with poor prognosis. Int J Radiat Oncol Biol Phys 88:580-8|
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