The Cancer Informatics Core (CIC) provides services, systems and tools to assist researchers In linking clinical phenotypes and other research data, with primary emphasis on: Clinical Informatics - Clinical informatics services through this core Include the identification, extraction, transformation, and interpretation of clinical data, whether captured as a part of routine care or through research activities. caBIG consulting and deployment - The CIC provides consulting services regarding caBIG technology and tools and also coordinates UMCCC's involvement with the caBIG program (for example, deploying caTISSUE to address issues associated with biospecimen repositories). Bioinformatics - Bioinformatics services include consulting on methodology and appropriate application of technology, a variety of analytical methods, and Integration of analysis from multiple experiments. The majority of the CIC's activities leverage larger IT-service providers in the University of Michigan Health System (UMHS). Although the CIC is small compared with the total UMHS IT staff (the CIC had 3 FTEs in 2010, and will grow to 9 in 2011, compared to more than 800 IT staff across UMHS), its effect is substantially magnified through leveraged Interactions with other, much larger existing resources. Accordingly, the CIC adheres to established and emerging standards and, where possible, uses software developed by national cooperative projects such as caBIG and the CTSAs. Many units in the UMHS offer IT services that can be used by UMCCC researchers. Although the CIC Is, in theory, a facility with a seven-year history, its current configuration is just over one year old.
The Cancer Informatics Core provides highly specialized services, systems and tools to assist cancer researchers with analyzing large data sets used in basic, clinical and translational cancer research.
|Verhaegen, Monique E; Mangelberger, Doris; Harms, Paul W et al. (2015) Merkel cell polyomavirus small T antigen is oncogenic in transgenic mice. J Invest Dermatol 135:1415-24|
|Chinn, Steven B; Darr, Owen A; Owen, John H et al. (2015) Cancer stem cells: mediators of tumorigenesis and metastasis in head and neck squamous cell carcinoma. Head Neck 37:317-26|
|Castro, Maria G; Candolfi, Marianela; Wilson, Thomas J et al. (2014) Adenoviral vector-mediated gene therapy for gliomas: coming of age. Expert Opin Biol Ther 14:1241-57|
|Vainshtein, Jeffrey M; Spector, Matthew E; Stenmark, Matthew H et al. (2014) Reliability of post-chemoradiotherapy F-18-FDG PET/CT for prediction of locoregional failure in human papillomavirus-associated oropharyngeal cancer. Oral Oncol 50:234-9|
|Grogan, Patrick T; Sarkaria, Jann N; Timmermann, Barbara N et al. (2014) Oxidative cytotoxic agent withaferin A resensitizes temozolomide-resistant glioblastomas via MGMT depletion and induces apoptosis through Akt/mTOR pathway inhibitory modulation. Invest New Drugs 32:604-17|
|Vainshtein, Jeffrey M; Spector, Matthew E; McHugh, Jonathan B et al. (2014) Refining risk stratification for locoregional failure after chemoradiotherapy in human papillomavirus-associated oropharyngeal cancer. Oral Oncol 50:513-9|
|Krook, Melanie A; Nicholls, Lauren A; Scannell, Christopher A et al. (2014) Stress-induced CXCR4 promotes migration and invasion of ewing sarcoma. Mol Cancer Res 12:953-64|
|VanderVeen, Nathan; Paran, Christopher; Appelhans, Ashley et al. (2014) Marmosets as a preclinical model for testing "off-label" use of doxycycline to turn on Flt3L expression from high-capacity adenovirus vectors. Mol Ther Methods Clin Dev 1:|
|Stenmark, Matthew H; McHugh, Jonathan B; Schipper, Matthew et al. (2014) Nonendemic HPV-positive nasopharyngeal carcinoma: association with poor prognosis. Int J Radiat Oncol Biol Phys 88:580-8|
|Ro, Seung-Hyun; Semple, Ian A; Park, Haewon et al. (2014) Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1. FEBS J 281:3816-27|
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