(CANCER EPIDEMIOLOGY AND PREVENTION) The Cancer Epidemiology and Prevention (CEP) Program is a group of interdisciplinary population health and medical scientists that conduct research to elucidate environmental, lifestyle and genetic causes of cancer, and develop and test strategies and interventions to prevent and reduce the risk of cancer. CEP program members also focus on developing statistical and mathematical approaches to advance cancer research. The program is comprised of 29 members from 17 different departments and three schools with total annual direct research support of $5.8 million - of which $4.7 million (81%) is from the NCI. Members are highly productive, with 533 publications during the project period, of which 17.4% are intra-programmatic and 35.3% are inter- programmatic. Investigators are involved in intra- and inter-programmatic interactions and actively collaborate with researchers in the other University of Michigan Comprehensive Cancer Center programs. The CEP program has three main specific aims: 1) Elucidate risk and protective factors for common and high-mortality cancers, with a focus on lifestyle, environmental and molecular exposures; 2) Discover and implement primary, secondary and tertiary prevention strategies incorporating environmental and personal exposures and state-of- the-art genomic, proteomic, metabolomic, and imaging biotechnologies; and 3) Develop and operationalize novel biostatistical and analytic methods for big data and personalized prevention and screening.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA046592-29
Application #
9488245
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2018-06-01
Budget End
2019-05-31
Support Year
29
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Khoriaty, Rami; Hesketh, Geoffrey G; Bernard, Amélie et al. (2018) Functions of the COPII gene paralogs SEC23A and SEC23B are interchangeable in vivo. Proc Natl Acad Sci U S A 115:E7748-E7757
Katz, Steven J; Ward, Kevin C; Hamilton, Ann S et al. (2018) Gaps in Receipt of Clinically Indicated Genetic Counseling After Diagnosis of Breast Cancer. J Clin Oncol 36:1218-1224
Ulintz, Peter J; Greenson, Joel K; Wu, Rong et al. (2018) Lymph Node Metastases in Colon Cancer Are Polyclonal. Clin Cancer Res 24:2214-2224
Qin, Tingting; Zhang, Yanxiao; Zarins, Katie R et al. (2018) Expressed HNSCC variants by HPV-status in a well-characterized Michigan cohort. Sci Rep 8:11458
Xu, Shilin; Aguilar, Angelo; Xu, Tianfeng et al. (2018) Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein-Protein Interaction. Angew Chem Int Ed Engl 57:1601-1605
Crespo, Joel; Wu, Ke; Li, Wei et al. (2018) Human Naive T Cells Express Functional CXCL8 and Promote Tumorigenesis. J Immunol 201:814-820
Manohar, Poorni M; Beesley, Lauren J; Bellile, Emily L et al. (2018) Prognostic Value of FDG-PET/CT Metabolic Parameters in Metastatic Radioiodine-Refractory Differentiated Thyroid Cancer. Clin Nucl Med 43:641-647
Hawley, Sarah T; Li, Yun; An, Lawrence C et al. (2018) Improving Breast Cancer Surgical Treatment Decision Making: The iCanDecide Randomized Clinical Trial. J Clin Oncol 36:659-666
Salami, Simpa S; Hovelson, Daniel H; Kaplan, Jeremy B et al. (2018) Transcriptomic heterogeneity in multifocal prostate cancer. JCI Insight 3:
Smith, Joshua; Kulkarni, Aditi; Birkeland, Andrew C et al. (2018) Whole-Exome Sequencing of Sinonasal Small Cell Carcinoma Arising within a Papillary Schneiderian Carcinoma In Situ. Otolaryngol Head Neck Surg 159:859-865

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