The Clinical Research Service (CRS) was established in December, 1986 as a shared resource to facilitate development, implementation, and completion of all UPCI clinical research studies. A part of the global UPCI infrastructure for clinical trial support, the CRS works in tandem with the Protocol Review Committees (PRC) and the Data Safety and Monitoring Committee (DSMC); all three entities function under the oversight of the Clinical Research Oversight Committee (CROC). Adam Brufsky, M.D., Ph.D., Associate Director for Clinical Investigation oversees the CRS. Steve Mulcahy, MS serves as Director, CRS while Holly Goe, BSN, serves as Associate Director, CRS. The CRS serves as the coordinating center for oversight, management, and monitoring for all UPCI clinical research activities. It provides assistance with study development and implementation, IRB submission and processing of PRC-approved trials, patient recruitment, study coordination, and specimen and data collection for all investigators conducting cancer-related studies at the University of Pittsburgh and UPMC Cancer Centers. The CRS database Clinical Trials Management Application (CTMA) maintains up to date documentation on the status of each study and facilitates timely submission of all required documents and amendments to the IRB, study renewal forms, progress reports. Data Safety Monitoring information, Serious Adverse Events, monthly reports, IRB and other correspondence. The CRS has continued to grow and adapt to the scientific, regulatory and financial challenges of cancer clinical research.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA047904-24
Application #
8382694
Study Section
Special Emphasis Panel (ZCA1-RTRB-L)
Project Start
Project End
Budget Start
2012-08-01
Budget End
2013-07-31
Support Year
24
Fiscal Year
2012
Total Cost
$387,666
Indirect Cost
$78,573
Name
University of Pittsburgh
Department
Type
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Concha-Benavente, Fernando; Srivastava, Raghvendra M; Trivedi, Sumita et al. (2016) Identification of the Cell-Intrinsic and -Extrinsic Pathways Downstream of EGFR and IFNγ That Induce PD-L1 Expression in Head and Neck Cancer. Cancer Res 76:1031-43
Posluszny, Donna M; Dew, Mary Amanda; Beckjord, Ellen et al. (2016) Existential challenges experienced by lymphoma survivors: Results from the 2010 LIVESTRONG Survey. J Health Psychol 21:2357-66
Vyas, Avani R; Moura, Michelle B; Hahm, Eun-Ryeong et al. (2016) Sulforaphane Inhibits c-Myc-Mediated Prostate Cancer Stem-Like Traits. J Cell Biochem 117:2482-95
Pollack, Ian F; Jakacki, Regina I; Butterfield, Lisa H et al. (2016) Antigen-specific immunoreactivity and clinical outcome following vaccination with glioma-associated antigen peptides in children with recurrent high-grade gliomas: results of a pilot study. J Neurooncol :
Chen, Mingqing; Sun, Fan; Han, Lei et al. (2016) Kaposi's sarcoma herpesvirus (KSHV) microRNA K12-1 functions as an oncogene by activating NF-κB/IL-6/STAT3 signaling. Oncotarget 7:33363-73
Gojo, Ivana; Beumer, Jan H; Pratz, Keith W et al. (2016) A phase 1 study of the PARP inhibitor veliparib in combination with temozolomide in acute myeloid leukemia. Clin Cancer Res :
Delgado, Evan; Boisen, Michelle M; Laskey, Robin et al. (2016) High expression of orphan nuclear receptor NR4A1 in a subset of ovarian tumors with worse outcome. Gynecol Oncol 141:348-56
Kirkwood, Caitlin M; MacDonald, Matthew L; Schempf, Tadhg A et al. (2016) Altered Levels of Visinin-Like Protein 1 Correspond to Regional Neuronal Loss in Alzheimer Disease and Frontotemporal Lobar Degeneration. J Neuropathol Exp Neurol 75:175-82
Beumer, Jan H; Ding, Fei; Tawbi, Hussein et al. (2016) Effect of Renal Dysfunction on Toxicity in Three Decades of Cancer Therapy Evaluation Program-Sponsored Single-Agent Phase I Studies. J Clin Oncol 34:110-6
Whiteside, Theresa L (2016) Tumor-Derived Exosomes and Their Role in Cancer Progression. Adv Clin Chem 74:103-41

Showing the most recent 10 out of 885 publications