The Experimental and Developmental Therapeutics (EDT) program of the Cancer Therapy and Research Center (CTRC) at the University of Texas Health Science Center at San Antonio (UTHSCSA) is focused on improving the therapy of cancer through innovative pre-clinical and clinical research. The activities within this program span the range of experimental and developmental therapeutics from initial target discovery to regulatory approval for new treatments. This program identifies new therapeutic targets for cancer, new therapies and approaches directed at these targets, and has the expertise to help translate discoveries. The EDT program facilitates the assessment of novel therapies by fostering collaboration between pre-clinical and clinical researchers ultimately to provide patients with the best possible treatments. Key themes within EDT include: 1) identification of novel therapeutic targets, 2) synthesis and pre-clinical assessment of new compounds directed at specific targets and 3) preclinical assessment of compounds in novel cancer situations. The integration in December 2007 of UTHSCSA's cancer-focused resources with those of the CTRC's Institute for Drug Development (IDD) has allowed a greater emphasis on the efficient translation of preclinical research into eariy phase clinical studies within the EDT program and will allow rapid further Phase 11/111 exploration of promising approaches. The EDT program has 31 scientific members representing 8 departments from the School of Medicine, the Graduate School of Biomedical Sciences, and important components of the CTRC at UTHSCSA including the IDD and the Greehey Children's Cancer Research Institute. EDT program members currently receive $5.55 million (direct costs) annually in peer-reviewed grants from the NCI, NIH, FDA, and Department of Defense. Training is a very important component of the EDT program's activities. Program members train fellows and graduate students in pre-clinical and clinical departments. The IDD's Advanced Oncology/Hematology Drug Development Fellowship is a unique training program for physicians that focuses specifically on the multidisciplinary nature of anti-cancer therapy development. In summary, the EDT program is a highly integrated multidisciplinary collaborative effort between pre-clinical and clinical scientists, all focused on providing newer, better-targeted and more effective treatments for patients with cancer
The Experimental and Developmental Therapeutics (EDT) Program is the keystone of the CTRC at UTHSCSA's effort to develop and test new treatments for cancer. It is a highly integrated multidisciplinary collaborative effort between diverse disciplines of pre-clinical and clinical scientists, all of whom are focused on improving the prognosis of patients with cancer.
| Gong, Siqi; Tomusange, Khamis; Kulkarni, Viraj et al. (2018) Anti-HIV IgM protects against mucosal SHIV transmission. AIDS 32:F5-F13 |
| Soteros, Breeanne M; Cong, Qifei; Palmer, Christian R et al. (2018) Sociability and synapse subtype-specific defects in mice lacking SRPX2, a language-associated gene. PLoS One 13:e0199399 |
| Gelfond, Jonathan; Goros, Martin; Hernandez, Brian et al. (2018) A System for an Accountable Data Analysis Process in R. R J 10:6-21 |
| De La Chapa, Jorge J; Singha, Prajjal Kanti; Lee, Debbie R et al. (2018) Thymol inhibits oral squamous cell carcinoma growth via mitochondria-mediated apoptosis. J Oral Pathol Med 47:674-682 |
| Katti, Sachin; Her, Bin; Srivastava, Atul K et al. (2018) High affinity interactions of Pb2+ with synaptotagmin I. Metallomics 10:1211-1222 |
| Hariharan, Nisha; Ashcraft, Keith A; Svatek, Robert S et al. (2018) Adipose Tissue-Secreted Factors Alter Bladder Cancer Cell Migration. J Obes 2018:9247864 |
| Wang, Zhonghua; Bhattacharya, Akash; White, Tommy et al. (2018) Functionality of Redox-Active Cysteines Is Required for Restriction of Retroviral Replication by SAMHD1. Cell Rep 24:815-823 |
| Deng, Yilun; Qin, Yuejuan; Srikantan, Subramanya et al. (2018) The TMEM127 human tumor suppressor is a component of the mTORC1 lysosomal nutrient-sensing complex. Hum Mol Genet 27:1794-1808 |
| Wei, Zhen; Panneerdoss, Subbarayalu; Timilsina, Santosh et al. (2018) Topological Characterization of Human and Mouse m5C Epitranscriptome Revealed by Bisulfite Sequencing. Int J Genomics 2018:1351964 |
| Chiang, Huai-Chin; Zhang, Xiaowen; Zhao, Xiayan et al. (2018) Gene-Specific Genetic Complementation between Brca1 and Cobra1 During Mouse Mammary Gland Development. Sci Rep 8:2731 |
Showing the most recent 10 out of 989 publications
