This proposal for a Cancer Center Support Grant (CCSG) requests funding to support the cancer research activities of the Kimmel Cancer Center (KCC), in order to increase the survival and quality of life of cancer patients by translating basi research discoveries into new strategies to prevent, diagnose, monitor and cure human cancer. The major thrust of the Kimmel Cancer Center is in discovery and translation of the latest findings in the genetics, cell biology, biochemistry and immunology of cancer into novel modalities to cure cancer. The Kimmel Cancer Center consists of six programs and ten shared resources to support the research programs. Investigators in each program are involved in intra-programmatic and inter-programmatic collaborations and have been extremely successful in obtaining peer-reviewed funding for these collaborative studies. The environment within the KCC has facilitated numerous collaborative studies and publications that have contributed to important advances in cancer research. The KCC programs are supported by $56.3 million in total peer-reviewed sponsored funding. Funding comes from NCI sponsored projects totals $23.3 million. The efforts of the Director and his recruits have resulted in increased philanthropic University and Hospital support. The importance of cancer research and care at Thomas Jefferson University is reflected in the Director's authority over clinical and research activities at the Institution, encompassing 196,936 sq. ft. which includes the Breast Center, Oncology Center and research space. These state of the art KCC facilities enhance the translational cancer research effort of the Kimmel Cancer Center. The KCC has included the Lankenau Institute of Medical Research as part of the endorsed Consortium Cancer Center since 2007. The current submission also includes Drexel University cancer researchers. The inclusion of Drexel University cancer researchers extends a long-standing history of collaborative research publications and grants between consortium investigators.
This grant supports the basic and clinical research activities of the Kimmel Cancer Center, whose mission is to perform outstanding basic research in cancer, translate these novel discoveries to patient care and improve the quality of life of our cancer patients and their loved ones.
|Ozaki, Shinji; Vuyyuru, Raja; Kageyama, Ken et al. (2016) Establishment and Characterization of Orthotopic Mouse Models for Human Uveal Melanoma Hepatic Colonization. Am J Pathol 186:43-56|
|Teh, Jessica L F; Purwin, Timothy J; Greenawalt, Evan J et al. (2016) An In Vivo Reporter to Quantitatively and Temporally Analyze the Effects of CDK4/6 Inhibitor-Based Therapies in Melanoma. Cancer Res 76:5455-66|
|Zhao, Yongtong; Shapiro, Sandor S; Eto, Masumi (2016) F-actin clustering and cell dysmotility induced by the pathological W148R missense mutation of filamin B at the actin-binding domain. Am J Physiol Cell Physiol 310:C89-98|
|Lu, Huimin; Wang, Tao; Li, Jing et al. (2016) Î±vÎ²6 Integrin Promotes Castrate-Resistant Prostate Cancer through JNK1-Mediated Activation of Androgen Receptor. Cancer Res 76:5163-74|
|Hutcheson, Jack; Balaji, Uthra; Porembka, Matthew R et al. (2016) Immunologic and Metabolic Features of Pancreatic Ductal Adenocarcinoma Define Prognostic Subtypes of Disease. Clin Cancer Res 22:3606-17|
|Singh, Amrita; Fedele, Carmine; Lu, Huimin et al. (2016) Exosome-mediated Transfer of Î±vÎ²3 Integrin from Tumorigenic to Nontumorigenic Cells Promotes a Migratory Phenotype. Mol Cancer Res 14:1136-1146|
|Zhao, Qian; Deng, Shengqiong; Wang, Guangxue et al. (2016) A direct quantification method for measuring plasma MicroRNAs identified potential biomarkers for detecting metastatic breast cancer. Oncotarget 7:21865-74|
|Pattison, Amanda M; Blomain, Erik S; Merlino, Dante J et al. (2016) Intestinal Enteroids Model Guanylate Cyclase C-Dependent Secretion Induced by Heat-Stable Enterotoxins. Infect Immun 84:3083-91|
|Curry, Joseph M; Tassone, Patrick; Cotzia, Paolo et al. (2016) Multicompartment metabolism in papillary thyroid cancer. Laryngoscope 126:2410-8|
|Dowling, John P; Cai, Yubo; Bertin, John et al. (2016) Kinase-independent function of RIP1, critical for mature T-cell survival and proliferation. Cell Death Dis 7:e2379|
Showing the most recent 10 out of 674 publications