The Mouse Histology and Phenotyping Laboratory (MHPL) provides the Northwestern University research community with histopathology assessment of murine tissues by trained pathologists and comprehensive histology services performed by expert histotechnologists. In addition, training is provided for investigators to learn to detect gross anomalies in rodents, to harvest tissue from various organ systems and to perform immunohistochemical and special histological stains on tissue sections generated by the MHPL. The MHPL was developed to fulfill a need by the investigative community to assist with the analysis of new murine models, to leverage the expertise of pathologists in the histopathological assessment of tissue anomalies and neoplasms, and to increase the likelihood of extracting meaningful phenotypic information to guide future investigations. Murine tissue has histological characteristics distinct from human tissue and therefore accurate interpretation requires microscopic examination by.pathologists with an understanding of disease pathobiology, rodent histopathology and murine development. Moreover, tissue isolation, processing, and sectioning often require the involvement of highly skilled histotechnologists, especially when embryonic lethal phenotypes or complex developmental abnormalities are to be studied. The MHPL is directed by an anatomic pathologist and neuropathologist with more than twenty years of experience in diagnosing human tumors and developmental abnormalities. He has equally extensive training in rodent adult and developmental pathobiology and histopathology. Other members ofthe MHPL staff include a second fulltime associate pathologist, three full-time ASCP certified histotechnologists, two part-time histotechnologists and two part-time technical/administrative assistants. Together, this team provides a broad range of technical and diagnostic services to investigators throughout the Northwestern University research enterprise in a high-volume and fast-paced environment. These comprehensive histopathology support services enhance the ability of our Cancer Center investigators to characterize viable and embryonic lethal mouse models and to develop and analyze new in vivo model systems to study cancer biology.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA060553-19
Application #
8588645
Study Section
Subcommittee G - Education (NCI)
Project Start
1997-08-01
Project End
2018-07-31
Budget Start
2013-09-16
Budget End
2014-07-31
Support Year
19
Fiscal Year
2013
Total Cost
$125,108
Indirect Cost
$44,180
Name
Northwestern University at Chicago
Department
Type
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Moinpour, Carol M; Donaldson, Gary W; Davis, Kimberly M et al. (2017) The challenge of measuring intra-individual change in fatigue during cancer treatment. Qual Life Res 26:259-271
Lamar, Tyra; Vanoye, Carlos G; Calhoun, Jeffrey et al. (2017) SCN3A deficiency associated with increased seizure susceptibility. Neurobiol Dis 102:38-48
Yu, Dou; Khan, Omar F; SuvĂ , Mario L et al. (2017) Multiplexed RNAi therapy against brain tumor-initiating cells via lipopolymeric nanoparticle infusion delays glioblastoma progression. Proc Natl Acad Sci U S A 114:E6147-E6156
Mohr, David C; Tomasino, Kathryn Noth; Lattie, Emily G et al. (2017) IntelliCare: An Eclectic, Skills-Based App Suite for the Treatment of Depression and Anxiety. J Med Internet Res 19:e10
Apple, Alexandra C; Ryals, Anthony J; Alpert, Kathryn I et al. (2017) Subtle hippocampal deformities in breast cancer survivors with reduced episodic memory and self-reported cognitive concerns. Neuroimage Clin 14:685-691
Lampe, Johanna W; Huang, Ying; Neuhouser, Marian L et al. (2017) Dietary biomarker evaluation in a controlled feeding study in women from the Women's Health Initiative cohort. Am J Clin Nutr 105:466-475
Ichikawa, Yuichi; Connelly, Caitlin F; Appleboim, Alon et al. (2017) A synthetic biology approach to probing nucleosome symmetry. Elife 6:
Zhou, Qiyuan; Dai, Jingbo; Chen, Tianji et al. (2017) Downregulation of PKC?/Pard3/Pard6b is responsible for lung adenocarcinoma cell EMT and invasion. Cell Signal 38:49-59
Park, Jong Kook; Peng, Han; Yang, Wending et al. (2017) miR-184 exhibits angiostatic properties via regulation of Akt and VEGF signaling pathways. FASEB J 31:256-265
Raji, Idris; Yadudu, Fatima; Janeira, Emily et al. (2017) Bifunctional conjugates with potent inhibitory activity towards cyclooxygenase and histone deacetylase. Bioorg Med Chem 25:1202-1218

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