The Growth Factors &Signaling (GF) program is comprised of Members who focus on the central theme of signal transduction pathways relevant to cancer initiation, progression and metastasis. There are three goals that characterize this group: 1) study signaling pathways relevant to these three phases of oncogenesis, 2) develop new tools for the study of these signaling pathways, 3) develop compounds and strategies to target key components of these pathways, and 4) translate basic information into clinical applications. The GF Program has 29 Members, representing 12 Departments and five Schools, and has $5,602,675 in direct cancer-related peer-reviewed funding, 8 projects of which are funded by NCI for a direct total of $1,177,989. In 2007, Members published a total of 76 publications with 46 of those being cancer-related of which 28% were inter- and 9% were intra-related. This breadth is evident in three areas of study: Immune System and Cancer, Signaling in Epithelial Cancers, and Tools for Cancer Research and Therapeutics. Membership and GF activities have been reorganized over the past funding period. Program leadership changed to Dr. Marian L. Waterman and Dr. Nancy Allbritton in 2003, with a second change in leadership in 2007 when Dr. Christopher Hughes replaced Dr. Allbritton after her departure from UC Irvine. Membership has significantly changed since the last funding period with an active recruitment of Members from the bioengineering and chemistry disciplines and other Members moving to the Developmental Biology (DB) Program.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee G - Education (NCI)
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University of California Irvine
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Charney, Rebekah M; Forouzmand, Elmira; Cho, Jin Sun et al. (2017) Foxh1 Occupies cis-Regulatory Modules Prior to Dynamic Transcription Factor Interactions Controlling the Mesendoderm Gene Program. Dev Cell 40:595-607.e4
HD iPSC Consortium (2017) Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice. Nat Neurosci 20:648-660
McCracken, A N; McMonigle, R J; Tessier, J et al. (2017) Phosphorylation of a constrained azacyclic FTY720 analog enhances anti-leukemic activity without inducing S1P receptor activation. Leukemia 31:669-677
Barton, James C; Chen, Wen-Pin; Emond, Mary J et al. (2017) GNPAT p.D519G is independently associated with markedly increased iron stores in HFE p.C282Y homozygotes. Blood Cells Mol Dis 63:15-20
Yan, Huaming; Romero-Lopez, Monica; Frieboes, Hermann B et al. (2017) Multiscale Modeling of Glioblastoma Suggests that the Partial Disruption of Vessel/Cancer Stem Cell Crosstalk Can Promote Tumor Regression Without Increasing Invasiveness. IEEE Trans Biomed Eng 64:538-548
Klempner, Samuel J; Mehta, Pareen; Schrock, Alexa B et al. (2017) Cis-oriented solvent-front EGFR G796S mutation in tissue and ctDNA in a patient progressing on osimertinib: a case report and review of the literature. Lung Cancer (Auckl) 8:241-247
Molino, Nicholas M; Neek, Medea; Tucker, Jo Anne et al. (2017) Display of DNA on Nanoparticles for Targeting Antigen Presenting Cells. ACS Biomater Sci Eng 3:496-501
Lomeli, Naomi; Di, Kaijun; Czerniawski, Jennifer et al. (2017) Cisplatin-induced mitochondrial dysfunction is associated with impaired cognitive function in rats. Free Radic Biol Med 102:274-286
Huang, Jason Y; Samarasena, Jason B; Tsujino, Takeshi et al. (2017) EUS-guided portal pressure gradient measurement with a simple novel device: a human pilot study. Gastrointest Endosc 85:996-1001
Elbir, Haitham; Sitlani, Parth; Bergström, Sven et al. (2017) Chromosome and Megaplasmid Sequences of Borrelia anserina (Sakharoff 1891), the Agent of Avian Spirochetosis and Type Species of the Genus. Genome Announc 5:

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