The Onco-lmaging &Spectroscopy (OIS) Program is designed to pursue basic, translational, and clinical research involving the use of biomedical imaging in the diagnosis, early-detection, molecular imaging, staging, and treatment of cancer. The imaging technologies developed within this Program include both small animal and human devices. After successful evaluation of some of the small animal imaging technologies, they are upscaled for human oncological imaging and used in translational clinical projects. The program is supported by two UCI centers, the Beckman Laser Institute (BLI) and the Center for Functional Onco-lmaging, both located on UCI's South Campus. Both of these Centers join their respective strengths to pursue a strong research program in cancer imaging through the Center. The goals of the OIS Program are multi-fold. First is to develop biophotonics technologies uniquely suited for oncological studies, focused on the application of optical measurement techniques in various types of cancer including breast, skin, and Gl for the purposes of early diagnosis and determination of therapeutic response. The second goal is to develop and validate multi-modality imaging technologies combining various different technologies such as MRI-DOT, MRI-FT, MRI-SPECT, and XCT-FT. It has been shown that such multimodality devices combine anatomical landmarks with molecular signatures for improved detection and determination of therapeutic response. The third goal is to translate the developed imaging technologies to human studies. The application of DCE-MRI is an excellent example of this effort, having been developed and validated in animal models of cancer in the mid-1990s and has been successfully applied in human studies since late 1990s. The fourth goal is to apply the developed imaging technologies in clinical trials. The OIS Program has 18 Members, representing eight Departments and three Schools, and has $4,787,231 in direct cancer-related peer-reviewed funding, six projects of which are funded by NCI for a direct total of $2,060,049. In 2007, Members published a total of 44 publications with 20 of those being cancer-related of which 65% were inter- and 65% were intra-related.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee G - Education (NCI)
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University of California Irvine
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Charney, Rebekah M; Forouzmand, Elmira; Cho, Jin Sun et al. (2017) Foxh1 Occupies cis-Regulatory Modules Prior to Dynamic Transcription Factor Interactions Controlling the Mesendoderm Gene Program. Dev Cell 40:595-607.e4
HD iPSC Consortium (2017) Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice. Nat Neurosci 20:648-660
McCracken, A N; McMonigle, R J; Tessier, J et al. (2017) Phosphorylation of a constrained azacyclic FTY720 analog enhances anti-leukemic activity without inducing S1P receptor activation. Leukemia 31:669-677
Barton, James C; Chen, Wen-Pin; Emond, Mary J et al. (2017) GNPAT p.D519G is independently associated with markedly increased iron stores in HFE p.C282Y homozygotes. Blood Cells Mol Dis 63:15-20
Yan, Huaming; Romero-Lopez, Monica; Frieboes, Hermann B et al. (2017) Multiscale Modeling of Glioblastoma Suggests that the Partial Disruption of Vessel/Cancer Stem Cell Crosstalk Can Promote Tumor Regression Without Increasing Invasiveness. IEEE Trans Biomed Eng 64:538-548
Klempner, Samuel J; Mehta, Pareen; Schrock, Alexa B et al. (2017) Cis-oriented solvent-front EGFR G796S mutation in tissue and ctDNA in a patient progressing on osimertinib: a case report and review of the literature. Lung Cancer (Auckl) 8:241-247
Molino, Nicholas M; Neek, Medea; Tucker, Jo Anne et al. (2017) Display of DNA on Nanoparticles for Targeting Antigen Presenting Cells. ACS Biomater Sci Eng 3:496-501
Lomeli, Naomi; Di, Kaijun; Czerniawski, Jennifer et al. (2017) Cisplatin-induced mitochondrial dysfunction is associated with impaired cognitive function in rats. Free Radic Biol Med 102:274-286
Huang, Jason Y; Samarasena, Jason B; Tsujino, Takeshi et al. (2017) EUS-guided portal pressure gradient measurement with a simple novel device: a human pilot study. Gastrointest Endosc 85:996-1001
Elbir, Haitham; Sitlani, Parth; Bergström, Sven et al. (2017) Chromosome and Megaplasmid Sequences of Borrelia anserina (Sakharoff 1891), the Agent of Avian Spirochetosis and Type Species of the Genus. Genome Announc 5:

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