During the past project period, CCSG development funds were provided to launch the Survey and Biospecimen Shared Resource (SBSR). The SBSR provides high-quality laboratory and survey services to support Vanderbilt investigators conducting epidemiologic, clinical, and other population-based research. Major services provided by the SBSR include consultation for study design and protocol development, processing of biological samples, DNA extraction, biospecimen storage and requisition, genotyping assays, project management, interviewer-administered telephone surveys, web-based surveys, and other data collection methods. Most epidemiologic and clinical investigators do not have their own laboratories and are unfamiliar with laboratory operations. At the same time, most basic science labs are unequipped to handle the large volume of samples in epidemiologic studies. Furthermore, most clinical investigators do not have the expertise, time or resources to develop questionnaires, data collection systems, and study procedures. The SBSR enables investigators to access significant expertise and experience in epidemiologic research, avoid the start-up costs associated with hiring and training staff for data collection and sample processing, and share experienced research staff with other projects to reduce study costs. By implementing rigorous quality control protocols, SBSR significantly enhances the quality in data and specimen collection and processing. In its first year of operation, the SBSR has provided high quality services to more than 20 VICC members and supported research for multiple large studies, including three large cohort studies and two SPORE projects. The growth of the SBSR continues to escalate with the expansion of population and translational research at the VICC. The leadership team for the SBSR is composed of three investigators with extensive experience in epidemiology studies of lifestyle factors and biomarkers for cancer. Wei Zheng, Ph.D., is the senior scientific director for the SBSR. Qiuyin Cai, Ph.D., is the scientific co-director overseeing operations for the laboratory services, while Martha Shrubsole, Ph.D. is the scientific co-director responsible for survey research services These investigators each bring unique and complementary expertise and knowledge to ensure the efficient operation of this highly functional shared resource.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA068485-18
Application #
8733545
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
18
Fiscal Year
2014
Total Cost
$165,637
Indirect Cost
$89,303
Name
Vanderbilt University Medical Center
Department
Type
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Paul, Pritha; Rellinger, Eric J; Qiao, Jingbo et al. (2017) Elevated TIMP-1 expression is associated with a prometastatic phenotype, disease relapse, and poor survival in neuroblastoma. Oncotarget 8:82609-82620
Stephenson, Jason R; Wang, Xiaohan; Perfitt, Tyler L et al. (2017) A Novel Human CAMK2A Mutation Disrupts Dendritic Morphology and Synaptic Transmission, and Causes ASD-Related Behaviors. J Neurosci 37:2216-2233
Bouziat, Romain; Hinterleitner, Reinhard; Brown, Judy J et al. (2017) Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease. Science 356:44-50
Moyo, T K; Wilson, C S; Moore, D J et al. (2017) Myc enhances B-cell receptor signaling in precancerous B cells and confers resistance to Btk inhibition. Oncogene 36:4653-4661
Vilgelm, Anna E; Cobb, Priscilla; Malikayil, Kiran et al. (2017) MDM2 Antagonists Counteract Drug-Induced DNA Damage. EBioMedicine 24:43-55
LePage, Daniel P; Metcalf, Jason A; Bordenstein, Sarah R et al. (2017) Prophage WO genes recapitulate and enhance Wolbachia-induced cytoplasmic incompatibility. Nature 543:243-247
Li, Jun; Smith, Jarrod A; Dawson, Eric S et al. (2017) Optimized Translocator Protein Ligand for Optical Molecular Imaging and Screening. Bioconjug Chem 28:1016-1023
Zhang, Juliet; Weinrich, Jarret A P; Russ, Jeffrey B et al. (2017) A Role for Dystonia-Associated Genes in Spinal GABAergic Interneuron Circuitry. Cell Rep 21:666-678
Aune, T M; Crooke 3rd, P S; Patrick, A E et al. (2017) Expression of long non-coding RNAs in autoimmunity and linkage to enhancer function and autoimmune disease risk genetic variants. J Autoimmun 81:99-109
Esbenshade, Adam J; Zhao, Zhiguo; Aftandilian, Catherine et al. (2017) Multisite external validation of a risk prediction model for the diagnosis of blood stream infections in febrile pediatric oncology patients without severe neutropenia. Cancer 123:3781-3790

Showing the most recent 10 out of 2332 publications