Preventing the initiation of tobacco or nicotine products is critical to comprehensive tobacco and cancer control. This Revision Application Relevant to the Family Smoking Prevention and Tobacco Control Act provides the opportunity to conduct novel research that increases our understanding on how to prevent tobacco and nicotine use among the most vulnerable populations: youths, young adults, and racial/ethnic groups at high risk for tobacco-caused cancers. The three proposed projects identify how consumer perceptions, product design characteristics, and/or individual traits influence willingness to smoke and susceptibility to menthol cigarette or e-cigarette use. Project 1 examines the perceptions of the sensory characteristics of menthol cigarettes and the contributions of taste sensitivity to susceptibility to menthol cigarette use among never smokers, experimenters, and new smokers aged 18-26. Studies show that menthol increases the likelihood of experimentation, but have not assessed how menthol influences smoking initiation among racial/ethnic groups at high risk for menthol cigarette smoking and lung cancer. This study can provide evidence to the FDA on the potential harm of menthol in cigarettes to vulnerable groups. Project 2 employs an experimental design to examine how e-cigarette advertisements influence implicit and explicit attitudes toward e-cigarettes as healthier alternatives to cigarettes and how the advertisements are associated with susceptibility to e-cigarette use among current smokers aged 18-35. Little is known about the influence of e-cigarette marketing on public perceptions of e-cigarettes. This study can provide the FDA with new knowledge that will inform future e-cigarette regulations and facilitate marketing restrictions on misleading health claims. Project 3 employs an experimental design to investigate how colors, models, and health labeling influence adolescent (aged 12-14) reactions to cigarette advertising and examine gender and racial/ethnic differences in implicit and explicit measures, smoking expectancies, identification with smokers, and willingness to smoke. Studies show that tobacco industry advertising and packaging influence smoking initiation, but little is known about the mechanisms by which they influence initiation. This study can inform the FDA's regulation of specific advertising components that influence positive reactions to advertising.

Public Health Relevance

Preventing the initiation of menthol cigarettes, regular cigarettes, and e-cigarettes could substantially reduce tobacco-related morbidity and mortality rates in the U.S. The studies will collectively advance our knowledge on how consumer perceptions of products, product design characteristics, and individual traits influence adolescents'and young adults'risk for the initiation of products. Study results could potentially impact FDA's decision to use its authority to adopt new policy-based prevention strategies.

Agency
National Institute of Health (NIH)
Type
Center Core Grants (P30)
Project #
3P30CA071789-14S4
Application #
8641479
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Shafik, Hasnaa
Project Start
Project End
Budget Start
Budget End
Support Year
14
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Hawaii
Department
None
Type
Organized Research Units
DUNS #
City
Honolulu
State
HI
Country
United States
Zip Code
96822
Fagan, Pebbles; Pokhrel, Pallav; Herzog, Thaddeus A et al. (2016) Nicotine Metabolism in Young Adult Daily Menthol and Nonmenthol Smokers. Nicotine Tob Res 18:437-46
Paladino, David; Yue, Peibin; Furuya, Hideki et al. (2016) A novel nuclear Src and p300 signaling axis controls migratory and invasive behavior in pancreatic cancer. Oncotarget 7:7253-67
Rosty, Christophe; Clendenning, Mark; Walsh, Michael D et al. (2016) Germline mutations in PMS2 and MLH1 in individuals with solitary loss of PMS2 expression in colorectal carcinomas from the Colon Cancer Family Registry Cohort. BMJ Open 6:e010293
Huang, Sijia; Chong, Nicole; Lewis, Nathan E et al. (2016) Novel personalized pathway-based metabolomics models reveal key metabolic pathways for breast cancer diagnosis. Genome Med 8:34
Kuo, Mei-Ling; Lee, Mabel Bin-Er; Tang, Michelle et al. (2016) PYCR1 and PYCR2 Interact and Collaborate with RRM2B to Protect Cells from Overt Oxidative Stress. Sci Rep 6:18846
Iwasaki, Motoki; Le Marchand, Loïc; Franke, Adrian A et al. (2016) Comparison of plasma levels of obesity-related biomarkers among Japanese populations in Tokyo, Japan, São Paulo, Brazil, and Hawaii, USA. Eur J Cancer Prev 25:41-9
Giorgi, Elena E; Li, Yuqing; Caberto, Christian P et al. (2016) No Association between the Mitochondrial Genome and Prostate Cancer Risk: The Multiethnic Cohort. Cancer Epidemiol Biomarkers Prev 25:1001-3
Leo, Q J N; Ollberding, N J; Wilkens, L R et al. (2016) Nutritional factors and non-Hodgkin lymphoma survival in an ethnically diverse population: the Multiethnic Cohort. Eur J Clin Nutr 70:41-6
Wu, Kana; Spiegelman, Donna; Hou, Tao et al. (2016) Associations between unprocessed red and processed meat, poultry, seafood and egg intake and the risk of prostate cancer: A pooled analysis of 15 prospective cohort studies. Int J Cancer 138:2368-82
Setiawan, Veronica Wendy; Wei, Pengxiao C; Hernandez, Brenda Y et al. (2016) Disparity in liver cancer incidence and chronic liver disease mortality by nativity in Hispanics: The Multiethnic Cohort. Cancer 122:1444-52

Showing the most recent 10 out of 283 publications