Preventing the initiation of tobacco or nicotine products is critical to comprehensive tobacco and cancer control. This Revision Application Relevant to the Family Smoking Prevention and Tobacco Control Act provides the opportunity to conduct novel research that increases our understanding on how to prevent tobacco and nicotine use among the most vulnerable populations: youths, young adults, and racial/ethnic groups at high risk for tobacco-caused cancers. The three proposed projects identify how consumer perceptions, product design characteristics, and/or individual traits influence willingness to smoke and susceptibility to menthol cigarette or e-cigarette use. Project 1 examines the perceptions of the sensory characteristics of menthol cigarettes and the contributions of taste sensitivity to susceptibility to menthol cigarette use among never smokers, experimenters, and new smokers aged 18-26. Studies show that menthol increases the likelihood of experimentation, but have not assessed how menthol influences smoking initiation among racial/ethnic groups at high risk for menthol cigarette smoking and lung cancer. This study can provide evidence to the FDA on the potential harm of menthol in cigarettes to vulnerable groups. Project 2 employs an experimental design to examine how e-cigarette advertisements influence implicit and explicit attitudes toward e-cigarettes as healthier alternatives to cigarettes and how the advertisements are associated with susceptibility to e-cigarette use among current smokers aged 18-35. Little is known about the influence of e-cigarette marketing on public perceptions of e-cigarettes. This study can provide the FDA with new knowledge that will inform future e-cigarette regulations and facilitate marketing restrictions on misleading health claims. Project 3 employs an experimental design to investigate how colors, models, and health labeling influence adolescent (aged 12-14) reactions to cigarette advertising and examine gender and racial/ethnic differences in implicit and explicit measures, smoking expectancies, identification with smokers, and willingness to smoke. Studies show that tobacco industry advertising and packaging influence smoking initiation, but little is known about the mechanisms by which they influence initiation. This study can inform the FDA's regulation of specific advertising components that influence positive reactions to advertising.
Preventing the initiation of menthol cigarettes, regular cigarettes, and e-cigarettes could substantially reduce tobacco-related morbidity and mortality rates in the U.S. The studies will collectively advance our knowledge on how consumer perceptions of products, product design characteristics, and individual traits influence adolescents'and young adults'risk for the initiation of products. Study results could potentially impact FDA's decision to use its authority to adopt new policy-based prevention strategies.
|Guo, Zhenying; Carbone, Michele; Zhang, Xing et al. (2017) Improving the Accuracy of Mesothelioma Diagnosis in China. J Thorac Oncol 12:714-723|
|Furuya, Hideki; Shimizu, Yoshiko; Tamashiro, Paulette M et al. (2017) Sphingosine kinase 1 expression enhances colon tumor growth. J Transl Med 15:120|
|Xie, Guoxiang; Wang, Xiaoning; Zhao, Aihua et al. (2017) Sex-dependent effects on gut microbiota regulate hepatic carcinogenic outcomes. Sci Rep 7:45232|
|Lloyd, Yukie M; Ngati, Elise P; Salanti, Ali et al. (2017) A versatile, high through-put, bead-based phagocytosis assay for Plasmodium falciparum. Sci Rep 7:14705|
|Park, Sungshim L; Murphy, Sharon E; Wilkens, Lynne R et al. (2017) Association of CYP2A6 activity with lung cancer incidence in smokers: The multiethnic cohort study. PLoS One 12:e0178435|
|Conroy, Shannon M; Clarke, Christina A; Yang, Juan et al. (2017) Contextual Impact of Neighborhood Obesogenic Factors on Postmenopausal Breast Cancer: The Multiethnic Cohort. Cancer Epidemiol Biomarkers Prev 26:480-489|
|Huang, Madelyn C; Douillet, Christelle; Su, Mingming et al. (2017) Metabolomic profiles of arsenic (+3 oxidation state) methyltransferase knockout mice: effect of sex and arsenic exposure. Arch Toxicol 91:189-202|
|Boushey, Carol J; Spoden, Melissa; Delp, Edward J et al. (2017) Reported Energy Intake Accuracy Compared to Doubly Labeled Water and Usability of the Mobile Food Record among Community Dwelling Adults. Nutrients 9:|
|Mao, Weimin; Zhang, Xing; Guo, Zhenying et al. (2017) Association of Asbestos Exposure With Malignant Mesothelioma Incidence in Eastern China. JAMA Oncol 3:562-564|
|Harmon, Brook E; Wirth, Michael D; Boushey, Carol J et al. (2017) The Dietary Inflammatory Index Is Associated with Colorectal Cancer Risk in the Multiethnic Cohort. J Nutr 147:430-438|
Showing the most recent 10 out of 525 publications