The tobacco industry is relying on product and marketing innovation to drive future growth. The electronic or e- cigarette market provides a much needed area of growth for tobacco manufacturers, including the major cigarette manufacturers. The cigar market is another potential area for growth given the extensive variety of products available. E-cigarettes and cigars are not currently subject to the same FDA regulations as cigarettes and as result, the flavorings, product descriptors;and packaging in these markets vary more widely. In addition, the marketing strategies for e-cigarettes appear to highlight their potential for harm reduction. Such marketing will likely stimulate demand as well as questions to providers from patients about the safety of-cigarettes. Marketing of e-cigarettes has also become more mainstream as more brands are nationally advertised. Brand as well as flavor and packaging are also particularly important to cigar users. This revision application describes a plan to conduct three individual research projects that provide scientific data that can inform FDA regulation of e-cigarettes and cigars. These three projects respond to four of the FDA Center for Tobacco Products'research interest areas identified in the FOA including areas 2 (cigar use and perceptions), 4 (e-cigarette use and perceptions), 6 (impact of tobacco product characteristics on initiation) and 10 (effective communication strategies regarding the risk of tobacco products). Specifically, we plan to examine patient-provider communication related to e-cigarettes, explore the influence of ecigarette marketing on consumer perceptions and product trial, and investigate the impact of cigar product characteristics on young adults'cigar use and perceptions. Quantitative and qualitative data will be collected on the multiple factors that potentially influence the use of these products. Thus, the significance of this proposed research is its potential to generate a better understanding of e-cigarette and cigar use and perceptions which is vital to informing FDA tobacco product regulation.

Public Health Relevance

The purpose of this application seeks to better understand and address the factors that impact perceptions and use of e-cigarettes and cigars. The relevance of the proposed research to public health is its ability to advance the evidence base to inform FDA tobacco product regulation.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Marino, Michael A
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Rbhs -Cancer Institute of New Jersey
New Brunswick
United States
Zip Code
CeliĆ -Terrassa, Toni; Liu, Daniel D; Choudhury, Abrar et al. (2017) Normal and cancerous mammary stem cells evade interferon-induced constraint through the miR-199a-LCOR axis. Nat Cell Biol 19:711-723
Giovenco, Daniel P; Miller Lo, Erin J; Lewis, M Jane et al. (2017) ""They're Pretty Much Made for Blunts"": Product Features That Facilitate Marijuana Use Among Young Adult Cigarillo Users in the United States. Nicotine Tob Res 19:1359-1364
Delnevo, Cristine D; Giovenco, Daniel P; Miller Lo, Erin J (2017) Changes in the Mass-merchandise Cigar Market since the Tobacco Control Act. Tob Regul Sci 3:S8-S16
Chen, Jayson X; Liu, Anna; Lee, Mao-Jung et al. (2017) ?- and ?-tocopherols inhibit phIP/DSS-induced colon carcinogenesis by protection against early cellular and DNA damages. Mol Carcinog 56:172-183
Douam, Florian; Soto Albrecht, Yentli E; Hrebikova, Gabriela et al. (2017) Type III Interferon-Mediated Signaling Is Critical for Controlling Live Attenuated Yellow Fever Virus Infection In Vivo. MBio 8:
Delnevo, Cristine D; Hrywna, Mary; Giovenco, Daniel P et al. (2017) Close, but no cigar: certain cigars are pseudo-cigarettes designed to evade regulation. Tob Control 26:349-354
Sun, Yu; Sheshadri, Namratha; Zong, Wei-Xing (2017) SERPINB3 and B4: From biochemistry to biology. Semin Cell Dev Biol 62:170-177
Chesson, Charles B; Zloza, Andrew (2017) Nanoparticles: augmenting tumor antigen presentation for vaccine and immunotherapy treatments of cancer. Nanomedicine (Lond) 12:2693-2706
Borrie, Melinda S; Campor, John S; Joshi, Hansa et al. (2017) Binding, sliding, and function of cohesin during transcriptional activation. Proc Natl Acad Sci U S A 114:E1062-E1071
Anantha, Rachel W; Simhadri, Srilatha; Foo, Tzeh Keong et al. (2017) Functional and mutational landscapes of BRCA1 for homology-directed repair and therapy resistance. Elife 6:

Showing the most recent 10 out of 709 publications