Moffitt Cancer Center has maintained a focused effort to increase the number of investigator-initiated early phase clinical studies. In 2010, investigators at Moffitt Cancer Center enrolled 354 patients on phase I or l/ll studies. Moffitt remains focused on investigator-initiated studies as a high priority. Services include protocol initiation, activation, coordination and administration, as well as coordination of study-related patient care and data collection. More specifically, the duties and functions of the clinical research coordinators, requested for this Protocol-Specific Research Support Core Facility, will be to coordinate phase I and pilot study clinical trials, including assisting with determining patient eligibility and registration and coordinating protocol-related care of patients enrolled on clinical studies. The research coordinator ensures completion of patient assessments for adverse event and toxicity grading, thorough documentation of all patient observations, and appropriate patient followup according to protocol design. The research coordinator is required to have an in-depth knowledge of protocol requirements and good clinical practices as set forth by Federal regulations. As the primary resource for the protocols, the research nurse/coordinator acts as liaison between investigators, primary care providers, Moffitt regulatory staff, and the sponsor. Along with the investigator, the research coordinator will screen, enroll, and follow study subjects, ensuring protocol compliance and close monitoring while the subjects are on study. The Core requests CCSG Support of $137,864 for support of four research nurses totaling 2 FTEs.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA076292-15
Application #
8495994
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2013-02-01
Budget End
2014-01-31
Support Year
15
Fiscal Year
2013
Total Cost
$78,699
Indirect Cost
$31,994
Name
H. Lee Moffitt Cancer Center & Research Institute
Department
Type
DUNS #
139301956
City
Tampa
State
FL
Country
United States
Zip Code
33612
Permuth, Jennifer B; Pirie, Ailith; Ann Chen, Y et al. (2016) Exome genotyping arrays to identify rare and low frequency variants associated with epithelial ovarian cancer risk. Hum Mol Genet 25:3600-3612
Weber, Jeffrey; Gibney, Geoffrey; Kudchadkar, Ragini et al. (2016) Phase I/II Study of Metastatic Melanoma Patients Treated with Nivolumab Who Had Progressed after Ipilimumab. Cancer Immunol Res 4:345-53
Reed, Damon R; Mascarenhas, Leo; Manning, Kathleen et al. (2016) Pediatric phase I trial of oral sorafenib and topotecan in refractory or recurrent pediatric solid malignancies. Cancer Med 5:294-303
Turner, Joel G; Dawson, Jana L; Grant, Steven et al. (2016) Treatment of acquired drug resistance in multiple myeloma by combination therapy with XPO1 and topoisomerase II inhibitors. J Hematol Oncol 9:73
Haake, Scott M; Li, Jiannong; Bai, Yun et al. (2016) Tyrosine Kinase Signaling in Clear Cell and Papillary Renal Cell Carcinoma Revealed by Mass Spectrometry-Based Phosphotyrosine Proteomics. Clin Cancer Res :
Schabath, Matthew B; Massion, Pierre P; Thompson, Zachary J et al. (2016) Differences in Patient Outcomes of Prevalence, Interval, and Screen-Detected Lung Cancers in the CT Arm of the National Lung Screening Trial. PLoS One 11:e0159880
Kim, Jae-Young; Welsh, Eric A; Fang, Bin et al. (2016) Phosphoproteomics Reveals MAPK Inhibitors Enhance MET- and EGFR-Driven AKT Signaling in KRAS-Mutant Lung Cancer. Mol Cancer Res 14:1019-1029
Extermann, Martine; Leeuwenburgh, Christiaan; Samiian, Laila et al. (2016) Impact of chemotherapy on medium-term physical function and activity of older breast cancer survivors, and associated biomarkers. J Geriatr Oncol :
Jiang, Kun; Neill, Kevin; Cowden, Daniel et al. (2016) Expression of CAS/CSE1L, the Cellular Apoptosis Susceptibility Protein, Correlates With Neoplastic Progression in Barrett's Esophagus. Appl Immunohistochem Mol Morphol :
Sung, Hyeran; Kanchi, Krishna L; Wang, Xue et al. (2016) Inactivation of RASA1 promotes melanoma tumorigenesis via R-Ras activation. Oncotarget 7:23885-96

Showing the most recent 10 out of 974 publications