The Analytic Microscopy Core Facility (AMC) was established in 1999 to provide investigators with the tools and technical expertise required for acquisition and analysis of advanced optical microscopy applications. Optical microscopy offers investigators the ability to visualize and quantify complex cellular and sub-cellular level processes in multiple dimensions. The core's goal is to provide expert training, experimental planning, hands-on assistance, coupled with state-of-the-art instrumentation and responsible equipment maintenance. AMC is well equipped, skillfully staffed, heavily used and has proven to be an invaluable resource for Cancer Center researchers interested in the most demanding projects. The core seeks to continue to identify and obtain emerging technologies that meet the needs of Moffitt Members. Since the last renewal, the AMC has continued to experience a dramatic increase in usage, which has prompted the growth of services, instrumentation, and expert personnel. Since 2006, the Core has added five major instrument systems and upgraded four older existing systems. New equipment include Aperio's ScanScope XT slide scanning technology to include a higher throughput and more advanced analysis system also capable of fluorescent imaging;a state-of-the-art Leica SPS AOBS tandem laser scanning confocal microscope;a fully automated Zeiss Observer wide-field fluorescence inverted microscope;and a cluster of stand alone offline image analysis workstations. In addition to added instrumentation, the AMC hired an additional Microscopy Specialist 111 (Joseph Johnson in 2006) to supplement the Core Staff Scientist (Mark Lloyd in 2003) and Microscopy Specialist II (Nancy Burke in 2005). The Core requests CCSG Support of $109,212, which is 34% of its operational budget. Over 70% of usage is by Moffitt members and peer-reviewed cancer investigators.
The Analytic Microscopy Core is responsive to the science performed at the Cancer Center and committed to the acquisition of state-of-the-art instrumentation that is easy to use and that expands microscopy capabilities to meet the needs of Moffitt's members. This approach allows members to focus on their science and leaves the expertise, maintenance, and support of high-end microscopy equipment to a highly trained and dedicated full-time staff.
|Tauro, Marilena; Shay, Gemma; Sansil, Samer S et al. (2017) Bone-Seeking Matrix Metalloproteinase-2 Inhibitors Prevent Bone Metastatic Breast Cancer Growth. Mol Cancer Ther 16:494-505|
|Davis, Stacy N; Christy, Shannon M; Chavarria, Enmanuel A et al. (2017) A randomized controlled trial of a multicomponent, targeted, low-literacy educational intervention compared with a nontargeted intervention to boost colorectal cancer screening with fecal immunochemical testing in community clinics. Cancer 123:1390-1400|
|Song, Jinming; Hussaini, Mohammad; Zhang, Hailing et al. (2017) Comparison of the Mutational Profiles of Primary Myelofibrosis, Polycythemia Vera, and Essential Thrombocytosis. Am J Clin Pathol 147:444-452|
|Strom, Tobin; Harrison, Louis B; Giuliano, Anna R et al. (2017) Tumour radiosensitivity is associated with immune activation in solid tumours. Eur J Cancer 84:304-314|
|Heit, Claire; Marshall, Stephanie; Singh, Surrendra et al. (2017) Catalase deletion promotes prediabetic phenotype in mice. Free Radic Biol Med 103:48-56|
|Eksioglu, E A; Chen, X; Heider, K-H et al. (2017) Novel therapeutic approach to improve hematopoiesis in low risk MDS by targeting MDSCs with the Fc-engineered CD33 antibody BI 836858. Leukemia 31:2172-2180|
|Kamath, Vidya P; Torres-Roca, Javier F; Eschrich, Steven A (2017) Integrating Biological Covariates into Gene Expression-Based Predictors of Radiation Sensitivity. Int J Genomics 2017:6576840|
|Liu, Ying; Balagurunathan, Yoganand; Atwater, Thomas et al. (2017) Radiological Image Traits Predictive of Cancer Status in Pulmonary Nodules. Clin Cancer Res 23:1442-1449|
|Chen, Yi; Fisher, Kate J; Lloyd, Mark et al. (2017) Multiplexed Liquid Chromatography-Multiple Reaction Monitoring Mass Spectrometry Quantification of Cancer Signaling Proteins. Methods Mol Biol 1647:19-45|
|Extermann, Martine; Leeuwenburgh, Christiaan; Samiian, Laila et al. (2017) Impact of chemotherapy on medium-term physical function and activity of older breast cancer survivors, and associated biomarkers. J Geriatr Oncol 8:69-75|
Showing the most recent 10 out of 1137 publications