An important cancer research challenge is accessing substantial quantities of patient data collected while providing clinical care. At the last CCSG review, the reviewers encouraged the Moffitt Cancer Center (MCC) to develop a service facilitating member access to the data customarily collected on all cancer patients that is needed to conduct high-impact transdisciplinary research. As a result, in 2013, the MCC developed a core expressly designed to facilitate access to patient data, leveraging the MCC enterprise-wide Heath Research Informatics (HRI) data warehouse with discretely captured patient-level data (e.g., patient questionnaires, cancer registry, electronic health records, billing, and the Tissue Core biospecimen archive) on over 475,000 MCC patients. This MCC initiative developed the Collaborative Data Services Core (CDSC), now a fully- functioning core. The CDSC is a unique shared resource that facilitates MCC member use of patient-reported clinical, tumor, and biospecimen data in support of innovative research across all research programs. The CDSC supports members with three primary services: consultation, data provisioning, and study-specific medical record abstraction.
The specific aims that drive the CDSC are to: 1) Promote and facilitate cutting-edge translational research by providing members access to high- quality discrete patient-level data linked within MCC's enterprise-wide data warehouse and cost-efficient collection of clinical data from patient medical records; 2) Assist investigators at the early stages of developing research projects with consultations on study data access and project feasibility through provisioning of aggregate count data from the MCC HRI data warehouse; 3) Promote data access and data provisioning by providing individual or small group training, workshops, and data concierge training. The CDSC is led by Scientific Director Erin Siegel, PhD, MPH, who has extensive experience conducting epidemiological studies utilizing the HRI resource. The CDSC is also supported by a Facility Director, a Core Manager, and six staff members. In fiscal year 2015, the CDSC fulfilled service requests for 79 members across all five CCSG programs, which represents 72% of the total usage; 47% of usage was in support of peer-review funded members. During the five-year project period, the CDSC has contributed to at least 102 peer-reviewed publications and 31 peer-reviewed funded grants. The CDSC provides unique data provisioning and manual data abstraction services integrated in a typical project workflow in collaboration with several shared resources, including the Tissue Core, Biostatistics Core, and Cancer Informatics Core; it provides members access to enterprise-wide patient data to conduct cutting-edge, high-impact translational and personalized medicine research.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA076292-19
Application #
9209816
Study Section
Subcommittee A - Cancer Centers (NCI-A)
Project Start
Project End
Budget Start
2017-02-01
Budget End
2018-01-31
Support Year
19
Fiscal Year
2017
Total Cost
$98,504
Indirect Cost
$41,234
Name
H. Lee Moffitt Cancer Center & Research Institute
Department
Type
Research Institutes
DUNS #
139301956
City
Tampa
State
FL
Country
United States
Zip Code
33612
Davis, Stacy N; Govindaraju, Swapamthi; Jackson, Brittany et al. (2018) Recruitment Techniques and Strategies in a Community-Based Colorectal Cancer Screening Study of Men and Women of African Ancestry. Nurs Res 67:212-221
Martínez, Úrsula; Brandon, Thomas H; Sutton, Steven K et al. (2018) Associations between the smoking-relatedness of a cancer type, cessation attitudes and beliefs, and future abstinence among recent quitters. Psychooncology 27:2104-2110
Perales-Puchalt, Alfredo; Perez-Sanz, Jairo; Payne, Kyle K et al. (2018) Frontline Science: Microbiota reconstitution restores intestinal integrity after cisplatin therapy. J Leukoc Biol 103:799-805
Nelson, Ashley M; Jim, Heather S L; Small, Brent J et al. (2018) Sleep disruption among cancer patients following autologous hematopoietic cell transplantation. Bone Marrow Transplant 53:307-314
Singh, Kshipra; Coburn, Lori A; Asim, Mohammad et al. (2018) Ornithine Decarboxylase in Macrophages Exacerbates Colitis and Promotes Colitis-Associated Colon Carcinogenesis by Impairing M1 Immune Responses. Cancer Res 78:4303-4315
Kasting, Monica L; Giuliano, Anna R; Reich, Richard R et al. (2018) Hepatitis C Virus Screening Trends: Serial Cross-Sectional Analysis of the National Health Interview Survey Population, 2013-2015. Cancer Epidemiol Biomarkers Prev 27:503-513
Denson, Aaron; Burke, Nancy; Wapinsky, Georgine et al. (2018) Clinical Outcomes of Patients With Gastrointestinal Malignancies Participating in Phase I Clinical Trials. Am J Clin Oncol 41:133-139
Betts, Brian C; Bastian, David; Iamsawat, Supinya et al. (2018) Targeting JAK2 reduces GVHD and xenograft rejection through regulation of T cell differentiation. Proc Natl Acad Sci U S A 115:1582-1587
Pidala, Joseph; Beato, Francisca; Kim, Jongphil et al. (2018) In vivo IL-12/IL-23p40 neutralization blocks Th1/Th17 response after allogeneic hematopoietic cell transplantation. Haematologica 103:531-539
Hampras, S S; Tommasino, M; Zhao, Y et al. (2018) Cross-sectional associations between cutaneous viral infections and regulatory T lymphocytes in circulation. Br J Dermatol :

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