An important cancer research challenge is accessing substantial quantities of patient data collected while providing clinical care. At the last CCSG review, the reviewers encouraged the Moffitt Cancer Center (MCC) to develop a service facilitating member access to the data customarily collected on all cancer patients that is needed to conduct high-impact transdisciplinary research. As a result, in 2013, the MCC developed a core expressly designed to facilitate access to patient data, leveraging the MCC enterprise-wide Heath Research Informatics (HRI) data warehouse with discretely captured patient-level data (e.g., patient questionnaires, cancer registry, electronic health records, billing, and the Tissue Core biospecimen archive) on over 475,000 MCC patients. This MCC initiative developed the Collaborative Data Services Core (CDSC), now a fully- functioning core. The CDSC is a unique shared resource that facilitates MCC member use of patient-reported clinical, tumor, and biospecimen data in support of innovative research across all research programs. The CDSC supports members with three primary services: consultation, data provisioning, and study-specific medical record abstraction.
The specific aims that drive the CDSC are to: 1) Promote and facilitate cutting-edge translational research by providing members access to high- quality discrete patient-level data linked within MCC's enterprise-wide data warehouse and cost-efficient collection of clinical data from patient medical records; 2) Assist investigators at the early stages of developing research projects with consultations on study data access and project feasibility through provisioning of aggregate count data from the MCC HRI data warehouse; 3) Promote data access and data provisioning by providing individual or small group training, workshops, and data concierge training. The CDSC is led by Scientific Director Erin Siegel, PhD, MPH, who has extensive experience conducting epidemiological studies utilizing the HRI resource. The CDSC is also supported by a Facility Director, a Core Manager, and six staff members. In fiscal year 2015, the CDSC fulfilled service requests for 79 members across all five CCSG programs, which represents 72% of the total usage; 47% of usage was in support of peer-review funded members. During the five-year project period, the CDSC has contributed to at least 102 peer-reviewed publications and 31 peer-reviewed funded grants. The CDSC provides unique data provisioning and manual data abstraction services integrated in a typical project workflow in collaboration with several shared resources, including the Tissue Core, Biostatistics Core, and Cancer Informatics Core; it provides members access to enterprise-wide patient data to conduct cutting-edge, high-impact translational and personalized medicine research.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
Project #
Application #
Study Section
Subcommittee A - Cancer Centers (NCI-A)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
H. Lee Moffitt Cancer Center & Research Institute
Research Institutes
United States
Zip Code
Tauro, Marilena; Shay, Gemma; Sansil, Samer S et al. (2017) Bone-Seeking Matrix Metalloproteinase-2 Inhibitors Prevent Bone Metastatic Breast Cancer Growth. Mol Cancer Ther 16:494-505
Davis, Stacy N; Christy, Shannon M; Chavarria, Enmanuel A et al. (2017) A randomized controlled trial of a multicomponent, targeted, low-literacy educational intervention compared with a nontargeted intervention to boost colorectal cancer screening with fecal immunochemical testing in community clinics. Cancer 123:1390-1400
Song, Jinming; Hussaini, Mohammad; Zhang, Hailing et al. (2017) Comparison of the Mutational Profiles of Primary Myelofibrosis, Polycythemia Vera, and Essential Thrombocytosis. Am J Clin Pathol 147:444-452
Strom, Tobin; Harrison, Louis B; Giuliano, Anna R et al. (2017) Tumour radiosensitivity is associated with immune activation in solid tumours. Eur J Cancer 84:304-314
Heit, Claire; Marshall, Stephanie; Singh, Surrendra et al. (2017) Catalase deletion promotes prediabetic phenotype in mice. Free Radic Biol Med 103:48-56
Eksioglu, E A; Chen, X; Heider, K-H et al. (2017) Novel therapeutic approach to improve hematopoiesis in low risk MDS by targeting MDSCs with the Fc-engineered CD33 antibody BI 836858. Leukemia 31:2172-2180
Kamath, Vidya P; Torres-Roca, Javier F; Eschrich, Steven A (2017) Integrating Biological Covariates into Gene Expression-Based Predictors of Radiation Sensitivity. Int J Genomics 2017:6576840
Liu, Ying; Balagurunathan, Yoganand; Atwater, Thomas et al. (2017) Radiological Image Traits Predictive of Cancer Status in Pulmonary Nodules. Clin Cancer Res 23:1442-1449
Chen, Yi; Fisher, Kate J; Lloyd, Mark et al. (2017) Multiplexed Liquid Chromatography-Multiple Reaction Monitoring Mass Spectrometry Quantification of Cancer Signaling Proteins. Methods Mol Biol 1647:19-45
Extermann, Martine; Leeuwenburgh, Christiaan; Samiian, Laila et al. (2017) Impact of chemotherapy on medium-term physical function and activity of older breast cancer survivors, and associated biomarkers. J Geriatr Oncol 8:69-75

Showing the most recent 10 out of 1137 publications