8.6.1 ABSTRACT The Women's Cancer Program, led by Douglas Yee, M.D. and Levi Downs, M.D., has 32 members, representing 13 departments and four schools. As of September 30, 2007, these members have a total of $6.6 million in peer reviewed, funded research projects for the current budget period. Since June 2003, their research has resulted in 281 publications, of which 18% were intra-programmatic and 17% were interprogrammatic. This program was created by combining the members of the Breast Cancer program with new members interested in gynecologic malignancies. By creating the Women's Cancer program, we strengthened existing collaborations, enhanced the interaction between members performing similarly themed research, provided additional scientific mentorship for clinical investigators, and enhanced our capacity for translational research. The scientific goals of the program are to improve detection and prevention strategies, study mechanisms basic to cancer biology, translate research findings into innovative clinical strategies. To achieve these goals, the program is organized into four research themes: 1) functional imaging for cancer diagnosis, staging, and prediction of response to therapy, 2) angiogensis in breast and ovarian cancer, 3) gene expression, cell signaling, and steroid hormone receptor biology, and 4) translational research in cancer prevention and treatmet.

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National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee G - Education (NCI)
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University of Minnesota Twin Cities
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Abbott, Kenneth L; Nyre, Erik T; Abrahante, Juan et al. (2015) The Candidate Cancer Gene Database: a database of cancer driver genes from forward genetic screens in mice. Nucleic Acids Res 43:D844-8
Yee, Douglas (2015) A tale of two receptors: insulin and insulin-like growth factor signaling in cancer. Clin Cancer Res 21:667-9
Daniel, A R; Gaviglio, A L; Knutson, T P et al. (2015) Progesterone receptor-B enhances estrogen responsiveness of breast cancer cells via scaffolding PELP1- and estrogen receptor-containing transcription complexes. Oncogene 34:506-15
Upadhyaya, Pramod; Hecht, Stephen S (2015) Quantitative analysis of 3'-hydroxynorcotinine in human urine. Nicotine Tob Res 17:524-9
Patel, Yesha M; Stram, Daniel O; Wilkens, Lynne R et al. (2015) The contribution of common genetic variation to nicotine and cotinine glucuronidation in multiple ethnic/racial populations. Cancer Epidemiol Biomarkers Prev 24:119-27
Takahashi, Yutaka; Hui, Susanta K (2014) Fast, simple, and informative patient-specific dose verification method for intensity modulated total marrow irradiation with helical tomotherapy. Radiat Oncol 9:34
Cooley, Sarah; Weisdorf, Daniel J; Guethlein, Lisbeth A et al. (2014) Donor killer cell Ig-like receptor B haplotypes, recipient HLA-C1, and HLA-C mismatch enhance the clinical benefit of unrelated transplantation for acute myelogenous leukemia. J Immunol 192:4592-600
Chen, Liddy M; Ibrahim, Joseph G; Chu, Haitao (2014) Flexible stopping boundaries when changing primary endpoints after unblinded interim analyses. J Biopharm Stat 24:817-33
Landman, Sean R; Hwang, Tae Hyun; Silverstein, Kevin A T et al. (2014) SHEAR: sample heterogeneity estimation and assembly by reference. BMC Genomics 15:84
Gates, Leah A; Phillips, Martin B; Matter, Brock A et al. (2014) Comparative metabolism of furan in rodent and human cryopreserved hepatocytes. Drug Metab Dispos 42:1132-6

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