8.7.1 ABSTRACT: TRANSPLANT BIOLOGY AND THERAPY The Transplant Biology and Therapy (TBT) Program, is a long-established group representing over 30 years of collaborative translational investigation. Led by Daniel Weisdorf, M.D. and John E.. Wagner, M.D., the TBT Program has 38 members, representing investigators affiliated with seven departments and Institutes within schools (Medical School, College of Pharmacy, School of Public Health). As of October 1, 2007, members had 61 distinct (27 peer-reviewed;34 other) externally funded research grants providing a total of $15.3 million in total support for the current budget period (: Since June 2003, their research has resulted in 288 publications, of which 47% were intra-programrriatic and 18% were inter-programmatic. The central research themes of the program include hematopoietic and noh-hematopoietic stem cell biology, hematopoietic cell transplant (HCT), immuriobiology and immune-based therapies as well as studies of tissue repair, peri-transplant complications, survivorship/late effects and quality of life. The Program emphasizes translational development of new agents for therapeutic application and testing in phase l-ll clinical trials with a future goal of moving Cancer Center investigator-initiated phase I and II studies to definitive, multi-institutional phase III clinical trials. The scientific goals of the program are to advance knowledge of human hematopoietic and non-hematopoietic stem cells and derivative populations, advance the understanding of innate and adaptive immunity and immune reconstitution and its use for therapy in conjunction with HCT, develop novel therapeutic approaches to eliminate or reduce the transplantassociated risks of graft failure, acute and chronic graft-versus-host disease (GVHD), opportunistic infection and relapse, and improve the short and long-term quality of life in HCT survivors. Since its inception in 1974, the TBT Program has been a world leader in the field, advancing and improving the effectiveness of transplant therapy through basic and translational research that is ultimately applied to the care of patients. TBT Program investigators use all resources of the University of Minnesota Cancer Center to advance both clinical and basic laboratory investigations.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
Project #
Application #
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Minnesota Twin Cities
United States
Zip Code
Abbott, Kenneth L; Nyre, Erik T; Abrahante, Juan et al. (2015) The Candidate Cancer Gene Database: a database of cancer driver genes from forward genetic screens in mice. Nucleic Acids Res 43:D844-8
Yee, Douglas (2015) A tale of two receptors: insulin and insulin-like growth factor signaling in cancer. Clin Cancer Res 21:667-9
Daniel, A R; Gaviglio, A L; Knutson, T P et al. (2015) Progesterone receptor-B enhances estrogen responsiveness of breast cancer cells via scaffolding PELP1- and estrogen receptor-containing transcription complexes. Oncogene 34:506-15
Upadhyaya, Pramod; Hecht, Stephen S (2015) Quantitative analysis of 3'-hydroxynorcotinine in human urine. Nicotine Tob Res 17:524-9
Patel, Yesha M; Stram, Daniel O; Wilkens, Lynne R et al. (2015) The contribution of common genetic variation to nicotine and cotinine glucuronidation in multiple ethnic/racial populations. Cancer Epidemiol Biomarkers Prev 24:119-27
Chen, Liddy M; Ibrahim, Joseph G; Chu, Haitao (2014) Flexible stopping boundaries when changing primary endpoints after unblinded interim analyses. J Biopharm Stat 24:817-33
Takahashi, Yutaka; Hui, Susanta K (2014) Fast, simple, and informative patient-specific dose verification method for intensity modulated total marrow irradiation with helical tomotherapy. Radiat Oncol 9:34
Cooley, Sarah; Weisdorf, Daniel J; Guethlein, Lisbeth A et al. (2014) Donor killer cell Ig-like receptor B haplotypes, recipient HLA-C1, and HLA-C mismatch enhance the clinical benefit of unrelated transplantation for acute myelogenous leukemia. J Immunol 192:4592-600
Gorden, Brandi H; Kim, Jong-Hyuk; Sarver, Aaron L et al. (2014) Identification of three molecular and functional subtypes in canine hemangiosarcoma through gene expression profiling and progenitor cell characterization. Am J Pathol 184:985-95
Landman, Sean R; Hwang, Tae Hyun; Silverstein, Kevin A T et al. (2014) SHEAR: sample heterogeneity estimation and assembly by reference. BMC Genomics 15:84

Showing the most recent 10 out of 319 publications