The mission of the Biostatistics and Bioinformatics Shared Resource is to provide centralized biostatistics and bioinformatics services, collaborative research, and data management support for the research projects of all members ofthe Masonic Cancer Center (MCC). This Resource provides biostatistics and bioinformatics expertise in the planning, conduct analysis, and reporting ofthe following types of studies: ? Cancer-related clinical studies ? Prognostic, predictive, and surrogate marker studies ? Population-based prevention studies ? Somatic and germline genetic studies ? Animal and laboratory experiments in both new therapies and the basic biology of cancers This Shared Resource ensures that experimental design, study monitoring, and data analyses take advantage of robust and efficient methods that reflect best practices in biostatistics and bioinformatics. The Resource currently has 6 faculty, 2 research associates, 4 senior research fellows, and 3 research fellows;this reflects an increase in seniority and strength from the last funding cycle, although the number of staff members remains the same. Dr. Chap Le, a Professor and Distinguished Teaching Professor of Biostatistics in the University of Minnesota School of Public Health, continues as the Director. Dr. Le is assisted by Mr. Bruce Lindgren, who coordinates the Biostatistics Group, and Dr. Aaron Sarver, who coordinates the Bioinformatics Group. The Biostatistics Group operates as a subunit ofthe Biostatistics Design and Analysis Center of the University of Minnesota Clinical and Translational Science Institute, and the Bioinformatics Group works closely with the University of Minnesota Supercomputer Institute. The Biostatistics and Bioinformatics Shared Resource provides consultation on all cancer-related clinical protocols and supports MCC members in preparing grant applications. Members of all Programs within the MCC make use ofthe services ofthe Biostatistics and Bioinformatics Shared Resource, making it critical to the functioning ofthe MCC.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee G - Education (NCI)
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University of Minnesota Twin Cities
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Pang, Jiuxia; Shen, Na; Yan, Fei et al. (2017) Thymoquinone exerts potent growth-suppressive activity on leukemia through DNA hypermethylation reversal in leukemia cells. Oncotarget 8:34453-34467
Lin, Weiming; Modiano, Jaime F; Ito, Daisuke (2017) Stage-specific embryonic antigen: determining expression in canine glioblastoma, melanoma, and mammary cancer cells. J Vet Sci 18:101-104
Winterhoff, Boris J; Maile, Makayla; Mitra, Amit Kumar et al. (2017) Single cell sequencing reveals heterogeneity within ovarian cancer epithelium and cancer associated stromal cells. Gynecol Oncol 144:598-606
Jaramillo, Ericka G; Mupere, Ezekiel; Opoka, Robert O et al. (2017) Delaying the start of iron until 28 days after antimalarial treatment is associated with lower incidence of subsequent illness in children with malaria and iron deficiency. PLoS One 12:e0183977
Zhao, Xianda; Li, Lihua; Starr, Timothy K et al. (2017) Tumor location impacts immune response in mouse models of colon cancer. Oncotarget 8:54775-54787
Lynn, Geoffrey E; Oliver, Jonathan D; Cornax, Ingrid et al. (2017) Experimental evaluation of Peromyscus leucopus as a reservoir host of the Ehrlichia muris-like agent. Parasit Vectors 10:48
Luangphakdy, Viviane; Elizabeth Pluhar, G; Piuzzi, Nicolás S et al. (2017) The Effect of Surgical Technique and Spacer Texture on Bone Regeneration: A Caprine Study Using the Masquelet Technique. Clin Orthop Relat Res 475:2575-2585
Boylan, Kristin L M; Buchanan, Petra C; Manion, Rory D et al. (2017) The expression of Nectin-4 on the surface of ovarian cancer cells alters their ability to adhere, migrate, aggregate, and proliferate. Oncotarget 8:9717-9738
Mallhi, K; Orchard, P J; Miller, W P et al. (2017) Non-myeloablative conditioning for second hematopoietic cell transplantation for graft failure in patients with non-malignant disorders: a prospective study and review of the literature. Bone Marrow Transplant 52:726-732
Richardson, Paul G; Smith, Angela R; Triplett, Brandon M et al. (2017) Earlier defibrotide initiation post-diagnosis of veno-occlusive disease/sinusoidal obstruction syndrome improves Day +100 survival following haematopoietic stem cell transplantation. Br J Haematol 178:112-118

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