The Hematopoietic Malignancies Program of the UCSF Helen Diller Family Comprehensive Cancer Center includes 18 members from eight academic departments. The Program is built upon extraordinary institutional strengths in basic and population sciences, outstanding clinical programs for the care of patients with leukemia, lymphoma, and myeloma;and a tradition of cross-disciplinary collaborations in scientific investigations. The Program activities comprise two broad themes: (1) Hematopoiesis and Myeloid Leukemogenesis;and (2) Lymphoid Growth Control and Lymphoid Malignancies. Within these major themes the Program has established a highly interactive interdisciplinary approach that includes efforts directed at: gene discovery;modeling leukemia and lymphoma-associated genetic lesions in the mouse;characterizing signal transduction pathways that are crucial for cellular growth control;testing experimental therapeutics with molecular analysis to ascertain mechanisms of drug action and drug resistance;and defining environmental risk factors that contribute to the development of hematologic cancers. The NCI and other peer-reviewed support for this group of investigators for the 2010-2011 academic year totaled $4,541,421. The Program has 9% intra-programmatic and 12.5% inter-programmatic publications.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA082103-16
Application #
8693936
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
16
Fiscal Year
2014
Total Cost
$143
Indirect Cost
$53
Name
University of California San Francisco
Department
Type
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
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Zhang, Jie; Yao, Tsun-Wen; Hashizume, Rintaro et al. (2017) Combined BRAFV600E and MEK blockade for BRAFV600E-mutant gliomas. J Neurooncol 131:495-505
Li, Megan; Kroetz, Deanna L (2017) Bevacizumab-induced hypertension: Clinical presentation and molecular understanding. Pharmacol Ther :
Aggarwal, Rahul; Behr, Spencer C; Paris, Pamela L et al. (2017) Real-Time Transferrin-Based PET Detects MYC-Positive Prostate Cancer. Mol Cancer Res 15:1221-1229

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