A. Recruitment Developmental funds to support the recruitment of new investigators to the IUSCC will be critical in the next funding cycle to accomplish our strategic plan of the Center. During the current funding cycle, developmental funds were used to support the growth of research programs through targeted faculty recruitments. Investigators were recruited to all four IUSCC programs (Cancer Control, Hematopoiesis, Microenvironment and Immunology, Breast Cancer, and Experimental and Developmental Therapeutics) to accomplish the strategic objectives of the Center which had been identified as needing to increase our Gl, breast, epidemiology, lung cancer, and hematopoiesis faculty as well as cancer control members. Eighteen faculty members were successfully recruited with primary appointments in eight departments. Of these, ten now hold peer reviewed federal cancer research grants. All recruitment objectives discussed in the previous CCSG application were addressed (behavioral science and basic science focused on Gl and ovarian cancers). Future recruiting efforts in the upcoming grant cycle will be targeted toward expanding our Breast Cancer, Cancer Control and EOT Programs as well as the developing programs Molecular and Environmental Carcinogenesis and Tumor Microenvironment, outlined in the IUSCC Strategic Plan. CCSG funds are often a critical component of the packages that we use to recruit top candidates and provide the Cancer Center Director with real input into the recruitment of top cancer investigators into the institution. B. Pilot Projects: Developmental funds are also pivotally important for support of pilot research projects. Until September 2006, the IUSCC allocated pilot project funds by internal review of applications responding to specific RFA's. These RFA's could target a specific cancer type or research program. Some required collaboration with members of the Purdue Cancer Center and were jointly funded by both Centers. Review criteria included scientific relevance, collaboration and potential for future peer-reviewed funding. The IUSCC supported nineteen such projects, which are shown in Table 1 later in this section. Traditional use of funds for pilot funding of IUSCC projects changed dramatically when in September 2006, IUSCC Senior Leaders began a new and innovative approach for the allocation of pilot research funds.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
Project #
Application #
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Indiana University-Purdue University at Indianapolis
United States
Zip Code
Broxmeyer, Hal E; Pelus, Louis M (2014) Inhibition of DPP4/CD26 and dmPGE? treatment enhances engraftment of mouse bone marrow hematopoietic stem cells. Blood Cells Mol Dis 53:34-8
Blue, Emily K; DiGiuseppe, Robert; Derr-Yellin, Ethel et al. (2014) Gestational diabetes induces alterations in the function of neonatal endothelial colony-forming cells. Pediatr Res 75:266-72
Miller, Kathy D; Althouse, Sandra K; Nabell, Lisle et al. (2014) A phase II study of medroxyprogesterone acetate in patients with hormone receptor negative metastatic breast cancer: translational breast cancer research consortium trial 007. Breast Cancer Res Treat 148:99-106
Chiorean, E Gabriela; Schneider, Bryan P; Akisik, Fatih M et al. (2014) Phase 1 pharmacogenetic and pharmacodynamic study of sorafenib with concurrent radiation therapy and gemcitabine in locally advanced unresectable pancreatic cancer. Int J Radiat Oncol Biol Phys 89:284-91
Nudelman, Kelly N H; Wang, Yang; McDonald, Brenna C et al. (2014) Altered cerebral blood flow one month after systemic chemotherapy for breast cancer: a prospective study using pulsed arterial spin labeling MRI perfusion. PLoS One 9:e96713
Hocevar, Barbara A; Kamendulis, Lisa M; Pu, Xinzhu et al. (2014) Contribution of environment and genetics to pancreatic cancer susceptibility. PLoS One 9:e90052
Chitteti, Brahmananda Reddy; Kobayashi, Michihiro; Cheng, Yinghua et al. (2014) CD166 regulates human and murine hematopoietic stem cells and the hematopoietic niche. Blood 124:519-29
Chitteti, Brahmananda Reddy; Srour, Edward F (2014) Cell cycle measurement of mouse hematopoietic stem/progenitor cells. Methods Mol Biol 1185:65-78
Chang, Hua-Chen; Lewis, David; Tung, Chun-Yu et al. (2014) Soypeptide lunasin in cytokine immunotherapy for lymphoma. Cancer Immunol Immunother 63:283-95
Speth, Jennifer M; Hoggatt, Jonathan; Singh, Pratibha et al. (2014) Pharmacologic increase in HIF1* enhances hematopoietic stem and progenitor homing and engraftment. Blood 123:203-7

Showing the most recent 10 out of 83 publications