The Radiation and Free Radical Research Core focuses on providing state of the art technologies to HCCC investigators studying the role of oxidative stress and redox biology as they relate to cancer biology and cancer therapy. There is growing evidence that oxidative stress and redox biology are critical determinants of cancer biology including the processes of initiation, promotion, and progression to malignancy as well as the prevention and treatment of cancer. The Radiation and Free Radical Research Core (RFRRC) was established to provide easy access to free radical and radiation biology expertise, reagents, technologies, and analysis for HCCC investigators doing basic, pre-clinical, and clinical research. The three basic services provided by the core are: 1) Ionizing radiation services and phosphorimaging as well as cell cycle analytical tools critical to understanding cellular responses to radio-chemo-therapy. 2) Electron paramagnetic resonance spectroscopy and other detection methodologies for measuring free radicals, singlet oxygen, nitric oxide and the array of related oxidants and oxidative damage products. 3) Antioxidant enzyme services to provide easy access to technologies for modifying and measuring molecules responsible for pro-oxidant formation, metabolism of reactive oxygen species, and mediators of redox biology including: anti-oxidant proteins, small molecular weight cellular thiols and reductants, as well as redox mediated signaling and gene expression pathways governing growth, differentiation, and cell injury processes. The RFRRC is unique in its ability to provide HCCC members easy access to such knowledge, reagents and resources. The expertise for the RFRRC is based in the Free Radical Cancer Biology Program, but the RFRRC had more than 80 HCCC members use its facilities from 2005-2009, representing all 6 HCCC programs. During this period of support the research activities facilitated by the services in the RFFRC significantly contributed to 135 peer reviewed publications.

Public Health Relevance

There is ongoing recognition of the role free radicals and oxidate events play in both carcinogenesis and cancer therapy. The Radiation and Free Radical Research Core provides HCCC members with the ability to irradiate cells, analyze free radical status within cells and assess the status of anti-oxidant enzymes. The research supported by the Radiation and Free Radical Research Core is, therefore, highly cancer relevant.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee G - Education (NCI)
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University of Iowa
Iowa City
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Chrisman, Matthew; Nothwehr, Faryle; Janz, Kathleen et al. (2015) Perceived Resources and Environmental Correlates of Domain-Specific Physical Activity in Rural Midwestern Adults. J Phys Act Health 12:962-7
Chrisman, Matthew; Nothwehr, Faryle; Yang, Ginger et al. (2015) Environmental influences on physical activity in rural Midwestern adults: a qualitative approach. Health Promot Pract 16:142-8
Makkouk, Amani; Weiner, George J (2015) Cancer immunotherapy and breaking immune tolerance: new approaches to an old challenge. Cancer Res 75:10-May
Naderi, Ali (2015) Coagulation factor VII is regulated by androgen receptor in breast cancer. Exp Cell Res 331:239-50
McDowell, Bradley D; Chapman, Cole G; Smith, Brian J et al. (2015) Pancreatectomy predicts improved survival for pancreatic adenocarcinoma: results of an instrumental variable analysis. Ann Surg 261:740-5
Ponto, Laura L Boles; Menda, Yusuf; Magnotta, Vincent A et al. (2015) Frontal hypometabolism in elderly breast cancer survivors determined by [(18)F]fluorodeoxyglucose (FDG) positron emission tomography (PET): a pilot study. Int J Geriatr Psychiatry 30:587-94
Chrischilles, Elizabeth A; McDowell, Bradley D; Rubenstein, Linda et al. (2015) Survivorship care planning and its influence on long-term patient-reported outcomes among colorectal and lung cancer survivors: the CanCORS disease-free survivor follow-up study. J Cancer Surviv 9:269-78
Makkouk, Amani; Joshi, Vijaya B; Wongrakpanich, Amaraporn et al. (2015) Biodegradable microparticles loaded with doxorubicin and CpG ODN for in situ immunization against cancer. AAPS J 17:184-93
Bhama, A R; Charlton, M E; Schmitt, M B et al. (2015) Factors associated with conversion from laparoscopic to open colectomy using the National Surgical Quality Improvement Program (NSQIP) database. Colorectal Dis 17:257-64
Hoover, Andrew C; Milhem, Mohammed M; Anderson, Carryn M et al. (2015) Efficacy of nelfinavir as monotherapy in refractory adenoid cystic carcinoma: Results of a phase II clinical trial. Head Neck 37:722-6

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