This application requests Cancer Center Support Grant funding for the Holden Comprehensive Cancer Center (HCCC) at the University of Iowa. This is the second CCSG competitive renewal for the HCCC. The HCCC functions administratively as a matrix Cancer Center with 189 Center members from six colleges and 36 departments across the University. It leverages the resources and expertise provided by the medical center and across the University to support and strengthen transdisciplinary cancer research. The HCCC has extensive support from both the institution and via private support. The members of the HCCC have $74.2 million in total annual cancer-related, peer-reviewed, external research support. Of this, over $20.4 million comes from the NCI. The HCCC is organized into six research programs that are each designed to be translational in nature. Together they encompass a broad spectrum of strength in basic laboratory, clinical and population research. These programs are 1) Cancer Immunology &Immunotherapy, 2) Cancer Signaling and Experimental Therapeutics, 3) Free Radical Cancer Biology, 4) Tumor Imaging, 5).Cancer Epidemiology, and 6) Cancer Genomics and Cell Growth. In addition to the Administrative Core, the HCCC supports eleven shared resources including: 1) DNA, 2) Gene Transfer Vector, 3) Radiation and Free Radical Research, 4) Flow Cytometry, 5) Central Microscopy Research Facility, 6) Small Animal Imaging, 7) Tissue Procurement 8) Bioinformatics, 9) Population Research, 10) Biostatistics, and 11) Clinical Trials Support. Through these programs and cores, and an effective organizational structure, the HCCC enhances interactions, supports collaborations, and sets the direction of future cancer research activities at the HCCC.
The Cancer Center Support Grant supports the infrastructure of the Holden Comprehensive Cancer Center. This infrastructure allows the Center to foster excellence in research across a broad spectrum of scientific areas relevant to cancer, and translate those advances to the clinic with the goal of reducing the morbidity and mortality of cancer.
|Machiela, Mitchell J; Lan, Qing; Slager, Susan L et al. (2016) Genetically predicted longer telomere length is associated with increased risk of B-cell lymphoma subtypes. Hum Mol Genet 25:1663-76|
|Fink, Aliza K; Yanik, Elizabeth L; Marshall, Bruce C et al. (2016) Cancer risk among lung transplant recipients with cystic fibrosis. J Cyst Fibros :|
|Mambetsariev, Nurbek; Lin, Wai W; Stunz, Laura L et al. (2016) Nuclear TRAF3 is a negative regulator of CREB in B cells. Proc Natl Acad Sci U S A 113:1032-7|
|Vander Weg, Mark W; Cozad, Ashley J; Howren, M Bryant et al. (2016) An individually-tailored smoking cessation intervention for rural Veterans: a pilot randomized trial. BMC Public Health 16:811|
|Schroeder, Mary C; Chapman, Cole G; Nattinger, Matthew C et al. (2016) Variation in geographic access to chemotherapy by definitions of providers and service locations: a population-based observational study. BMC Health Serv Res 16:274|
|Brooks, Jennifer D; John, Esther M; Mellemkjaer, Lene et al. (2016) Body mass index, weight change, and risk of second primary breast cancer in the WECARE study: influence of estrogen receptor status of the first breast cancer. Cancer Med 5:3282-3291|
|Craciun, Ioana; Fenner, Amanda M; Kerns, Robert J (2016) N-Arylacyl O-sulfonated aminoglycosides as novel inhibitors of human neutrophil elastase, cathepsin G and proteinase 3. Glycobiology 26:701-9|
|Wang, Bingxuan; Klaren, William D; Wels, Brian R et al. (2016) Dietary Manganese Modulates PCB126 Toxicity, Metal Status, and MnSOD in the Rat. Toxicol Sci 150:15-26|
|Klaren, William D; Gibson-Corley, Katherine N; Wels, Brian et al. (2016) Assessment of the Mitigative Capacity of Dietary Zinc on PCB126 Hepatotoxicity and the Contribution of Zinc to Toxicity. Chem Res Toxicol 29:851-9|
|Safaeian, M; Robbins, H A; Berndt, S I et al. (2016) Risk of Colorectal Cancer After Solid Organ Transplantation in the United States. Am J Transplant 16:960-7|
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