Cancer Genomics and Cell Growth Research in the newly developed Cancer Genomics and Cell Growth Program focuses on genetic and molecular events controlling normal versus malignant cell proliferation, differentiation and survival. The overall goal of the program is to define biologically significant genetic and molecular alterations in tumor cells so that information can be used to more effectively detect and treat human cancers. There are two major overlapping research themes within the program. Theme 1 is the study of genomic organization and cancer gene expression / analysis, which focuses on identifying and characterizing key genetic events related to cancer. Theme 2 involves the study of cell growth, differentiation, survival and transformation. Research within this theme examines the functional roles of eukaryotic genes and viruses in fundamental cell processes that contribute to tumor cell development and metastasis. Major accomplishments of the Cancer Genomics and Cell Growth Program over the past funding period include identification and characterization of novel cancer genes and/or biomarkers, development of novel animal tumor models to discover and assess cancer gene function in vivo, and studies defining the molecular involvement of human papilloma viruses in cervical as well as Head and Neck cancers. There are numerous past and present productive collaborations between members of the Program and with members of other Cancer Center programs. Key examples of intraprogrammatic research collaborations include a) studies revealing the role of chromatin binding proteins (such as RPA, DNA polymerases, HPl, transcription factors) in gene expression and how that impacts the cancer phenotype, b) studies defining basic mechanisms of viral infection and replication, and how that leads to cell transformation, and c) the discovery and subsequent functional analysis of novel genetic pathways of carcinogenesis. There are currently 16 NIH and NCI funded projects involving multiple Program members and/or HCCC members from other programs serving as co-Investigators. This new program consists of 36 members from 15 departments (11 basic science and 4 clinical departments) and 4 Colleges. Peer-reviewed, research funding for this program totals $9,107,617 with $2,741,157 (30%) coming from the NCI Program members published 312 cancer-related publications over the prior funding period. Of these, 14% were intraprogrammatic, 17% were inter-programmatic and 8% were both intra and inter-programmatic, for a total of 39% collaborative publications.

Public Health Relevance

Cancer is a disease of abnormal cell growth, survival and checkpoint regulation that results from altered gene expression. Our research is advancing our fundamental understanding of essential genes/genetic events and mechanisms that mediate the tumor cell phenotype. Such information has broad translational significance for genetic testing and diagnosis of human cancers, improved tumor classification and predicted outcomes, and development of novel anticancer therapies that target key events and regulators of carcinogenesis.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee G - Education (NCI)
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University of Iowa
Iowa City
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Chrisman, Matthew; Nothwehr, Faryle; Janz, Kathleen et al. (2015) Perceived Resources and Environmental Correlates of Domain-Specific Physical Activity in Rural Midwestern Adults. J Phys Act Health 12:962-7
Chrisman, Matthew; Nothwehr, Faryle; Yang, Ginger et al. (2015) Environmental influences on physical activity in rural Midwestern adults: a qualitative approach. Health Promot Pract 16:142-8
Makkouk, Amani; Weiner, George J (2015) Cancer immunotherapy and breaking immune tolerance: new approaches to an old challenge. Cancer Res 75:10-May
Naderi, Ali (2015) Coagulation factor VII is regulated by androgen receptor in breast cancer. Exp Cell Res 331:239-50
McDowell, Bradley D; Chapman, Cole G; Smith, Brian J et al. (2015) Pancreatectomy predicts improved survival for pancreatic adenocarcinoma: results of an instrumental variable analysis. Ann Surg 261:740-5
Ponto, Laura L Boles; Menda, Yusuf; Magnotta, Vincent A et al. (2015) Frontal hypometabolism in elderly breast cancer survivors determined by [(18)F]fluorodeoxyglucose (FDG) positron emission tomography (PET): a pilot study. Int J Geriatr Psychiatry 30:587-94
Chrischilles, Elizabeth A; McDowell, Bradley D; Rubenstein, Linda et al. (2015) Survivorship care planning and its influence on long-term patient-reported outcomes among colorectal and lung cancer survivors: the CanCORS disease-free survivor follow-up study. J Cancer Surviv 9:269-78
Makkouk, Amani; Joshi, Vijaya B; Wongrakpanich, Amaraporn et al. (2015) Biodegradable microparticles loaded with doxorubicin and CpG ODN for in situ immunization against cancer. AAPS J 17:184-93
Bhama, A R; Charlton, M E; Schmitt, M B et al. (2015) Factors associated with conversion from laparoscopic to open colectomy using the National Surgical Quality Improvement Program (NSQIP) database. Colorectal Dis 17:257-64
Hoover, Andrew C; Milhem, Mohammed M; Anderson, Carryn M et al. (2015) Efficacy of nelfinavir as monotherapy in refractory adenoid cystic carcinoma: Results of a phase II clinical trial. Head Neck 37:722-6

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