The Breast Cancer Research Program includes 29 faculty members from eight departments and two schools to form an integrated program that is dedicated to research on the prevention, diagnosis and treatment of breast cancer. The program is currently supported by $3,465,104 in NCI funding and $4,755,188 in other peer-reviewed funding. Program members have diverse interests including research into breast health communications, the pathology and biology of premalignant lesions, the development of intrinsic breast cancer subtype assays, translational research on endocrine therapy resistance in the context of cooperative group neoadjuvant endocrine therapy trials, the development of novel therapeutics that target both tumor cells and bone and the immune system cells. We are also very actively investigating novel imaging approaches for predicting response to hormonal therapy. In addition, the program is now collaborating with the Washington University Genome Sequencing Center in an effort to unravel the genetic changes associated with breast susceptibility, initiation, progression, relapse, and resistance. Program members are developing new breast cancer models in order to develop preclinical justifications for investigator initiated clinical trials in our developmental therapeutics programs. Classes of agent under development include phosphoinositol-3-kinase inhibitors, hedgehog inhibitors, check point homolog kinase (CHK1) inhibitors and Trop2 antibodies. The program consists of a number of basic, translational, and clinical investigators who meet weekly in a highly interactive scientific milieu. Large numbers of breast cancer patients are being treated on clinical protocols at Washington University with a number of Siteman Cancer Center cores are essential for the mission ofthe program, including the Clinical Trials Core, Imaging Response Assessment Team, Tissue Procurement Core, the Molecular and Genomic Analysis Core, the Biostatistics Core, the Bioinformatics Core, and the Proteomics Core.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee G - Education (NCI)
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Washington University
Saint Louis
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Engle, E K; Fisher, D A C; Miller, C A et al. (2015) Clonal evolution revealed by whole genome sequencing in a case of primary myelofibrosis transformed to secondary acute myeloid leukemia. Leukemia 29:869-76
Zihni, Ahmed M; Cavallo, Jaime A; Thompson Jr, Dominic M et al. (2015) Evaluation of absorbable mesh fixation devices at various deployment angles. Surg Endosc 29:1605-13
Rosenbaum, Joan L; Smith, Joan R; Yan, Yan et al. (2015) Impact of a Neonatal-Bereavement-Support DVD on Parental Grief: A Randomized Controlled Trial. Death Stud 39:191-200
Solga, Anne C; Pong, Winnie W; Walker, Jason et al. (2015) RNA-sequencing reveals oligodendrocyte and neuronal transcripts in microglia relevant to central nervous system disease. Glia 63:531-48
Yamada, Tomoko; Yang, Yue; Hemberg, Martin et al. (2014) Promoter decommissioning by the NuRD chromatin remodeling complex triggers synaptic connectivity in the mammalian brain. Neuron 83:122-34
Lewis Jr, James S; Ali, Sahirzeeshan; Luo, Jingqin et al. (2014) A quantitative histomorphometric classifier (QuHbIC) identifies aggressive versus indolent p16-positive oropharyngeal squamous cell carcinoma. Am J Surg Pathol 38:128-37
Griffey, Richard T; Jeffe, Donna B; Bailey, Thomas (2014) Emergency physicians' attitudes and preferences regarding computed tomography, radiation exposure, and imaging decision support. Acad Emerg Med 21:768-77
Jorns, Julie M; Thomas, Dafydd G; Healy, Patrick N et al. (2014) Estrogen receptor expression is high but is of lower intensity in tubular carcinoma than in well-differentiated invasive ductal carcinoma. Arch Pathol Lab Med 138:1507-13
Jeffe, Donna B; Andriole, Dorothy A; Wathington, Heather D et al. (2014) Educational outcomes for students enrolled in MD-PhD programs at medical school matriculation, 1995-2000: a national cohort study. Acad Med 89:84-93
Tait, Sarah; Pacheco, Jose M; Gao, Feng et al. (2014) Body mass index, diabetes, and triple-negative breast cancer prognosis. Breast Cancer Res Treat 146:189-97

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