The Imaging Response Assessment Team (IRAT) is a shared resource that focuses on accurate and reproducible assessment of imaging-based measurements in clinical cancer research. The IRAT assists in building imaging science into institutional clinical research early in project development, thus capitalizing on the use of imaging biomarkers of tumor response to provide critical information for optimum management and interpretation of therapeutic trials. To improve service in this area, the tumor response assessment core at Washington University was initiated under a CCSG IRAT supplement in 2005. The IRAT has continued operating during the year following the limited initial supplement This application demonstrates the IRAT has developed into a fully integrated shared resource core facility in SCC.
The specific aims of these efforts are to: (1) operate a core facility for assessment, consultation and quality control for routine tumor response evaluation with imaging;(2) fully implement and support a coordinated mechanism to improve protocol review/development processes for protocols using imaging;and (3) ensure that both conventional and novel tumor image analysis services are readily available for use in cancer clinical trials. The shared resource will support funded and unfunded institutional, cooperative group and industry-sponsored oncology research programs at WU with priority given to SCC members, especially new users of imaging technology. In summary, this proposal outlines an innovative IRAT shared resource core that is carefully matched to the specific needs of SCC. It focuses on appropriately increasing the role that quantitative imaging plays in cancer research and represents a proactive step towards providing image analysis services and the personnel needed to maintain the services. We expect the approach outlined herein will continue to be highly successful and lead to greatly increased volumes in the use of appropriately selected Imaging in phase 1, 11 and III studies.
Imaging methods are critically important in cancer clinical trials to define disease extent and to assess response of the cancer to treatment. Prior to the formation of the IRAT, imaging services available at WU were not provided in a standardized and coordinated fashion. Hence, delivery of these sen/ices through a shared resource provides SCC investigators with access to reproducible and rapid therapeutic response assessments, and will play an important role in testing new treatments for cancer
|Engle, E K; Fisher, D A C; Miller, C A et al. (2015) Clonal evolution revealed by whole genome sequencing in a case of primary myelofibrosis transformed to secondary acute myeloid leukemia. Leukemia 29:869-76|
|Zihni, Ahmed M; Cavallo, Jaime A; Thompson Jr, Dominic M et al. (2015) Evaluation of absorbable mesh fixation devices at various deployment angles. Surg Endosc 29:1605-13|
|Rosenbaum, Joan L; Smith, Joan R; Yan, Yan et al. (2015) Impact of a Neonatal-Bereavement-Support DVD on Parental Grief: A Randomized Controlled Trial. Death Stud 39:191-200|
|Solga, Anne C; Pong, Winnie W; Walker, Jason et al. (2015) RNA-sequencing reveals oligodendrocyte and neuronal transcripts in microglia relevant to central nervous system disease. Glia 63:531-48|
|Yamada, Tomoko; Yang, Yue; Hemberg, Martin et al. (2014) Promoter decommissioning by the NuRD chromatin remodeling complex triggers synaptic connectivity in the mammalian brain. Neuron 83:122-34|
|Lewis Jr, James S; Ali, Sahirzeeshan; Luo, Jingqin et al. (2014) A quantitative histomorphometric classifier (QuHbIC) identifies aggressive versus indolent p16-positive oropharyngeal squamous cell carcinoma. Am J Surg Pathol 38:128-37|
|Griffey, Richard T; Jeffe, Donna B; Bailey, Thomas (2014) Emergency physicians' attitudes and preferences regarding computed tomography, radiation exposure, and imaging decision support. Acad Emerg Med 21:768-77|
|Jorns, Julie M; Thomas, Dafydd G; Healy, Patrick N et al. (2014) Estrogen receptor expression is high but is of lower intensity in tubular carcinoma than in well-differentiated invasive ductal carcinoma. Arch Pathol Lab Med 138:1507-13|
|Jeffe, Donna B; Andriole, Dorothy A; Wathington, Heather D et al. (2014) Educational outcomes for students enrolled in MD-PhD programs at medical school matriculation, 1995-2000: a national cohort study. Acad Med 89:84-93|
|Tait, Sarah; Pacheco, Jose M; Gao, Feng et al. (2014) Body mass index, diabetes, and triple-negative breast cancer prognosis. Breast Cancer Res Treat 146:189-97|
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