The Imaging Response Assessment Team (IRAT) is a shared resource that focuses on accurate and reproducible assessment of imaging-based measurements in clinical cancer research. The IRAT assists in building imaging science into institutional clinical research early in project development, thus capitalizing on the use of imaging biomarkers of tumor response to provide critical information for optimum management and interpretation of therapeutic trials. To improve service in this area, the tumor response assessment core at Washington University was initiated under a CCSG IRAT supplement in 2005. The IRAT has continued operating during the year following the limited initial supplement This application demonstrates the IRAT has developed into a fully integrated shared resource core facility in SCC.
The specific aims of these efforts are to: (1) operate a core facility for assessment, consultation and quality control for routine tumor response evaluation with imaging;(2) fully implement and support a coordinated mechanism to improve protocol review/development processes for protocols using imaging;and (3) ensure that both conventional and novel tumor image analysis services are readily available for use in cancer clinical trials. The shared resource will support funded and unfunded institutional, cooperative group and industry-sponsored oncology research programs at WU with priority given to SCC members, especially new users of imaging technology. In summary, this proposal outlines an innovative IRAT shared resource core that is carefully matched to the specific needs of SCC. It focuses on appropriately increasing the role that quantitative imaging plays in cancer research and represents a proactive step towards providing image analysis services and the personnel needed to maintain the services. We expect the approach outlined herein will continue to be highly successful and lead to greatly increased volumes in the use of appropriately selected Imaging in phase 1, 11 and III studies.

Public Health Relevance

Imaging methods are critically important in cancer clinical trials to define disease extent and to assess response of the cancer to treatment. Prior to the formation of the IRAT, imaging services available at WU were not provided in a standardized and coordinated fashion. Hence, delivery of these sen/ices through a shared resource provides SCC investigators with access to reproducible and rapid therapeutic response assessments, and will play an important role in testing new treatments for cancer

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA091842-12
Application #
8520216
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
12
Fiscal Year
2013
Total Cost
$192,820
Indirect Cost
$53,162
Name
Washington University
Department
Type
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Abboud, Ramzi; Keller, Jesse; Slade, Michael et al. (2016) Severe Cytokine-Release Syndrome after T Cell-Replete Peripheral Blood Haploidentical Donor Transplantation Is Associated with Poor Survival and Anti-IL-6 Therapy Is Safe and Well Tolerated. Biol Blood Marrow Transplant 22:1851-60
Johnson, Kimberly J; Zoellner, Nancy L; Gutmann, David H (2016) Peri-gestational risk factors for pediatric brain tumors in Neurofibromatosis Type 1. Cancer Epidemiol 42:53-9
Zuiani, Adam; Chen, Kevin; Schwarz, Megan C et al. (2016) A Library of Infectious Hepatitis C Viruses with Engineered Mutations in the E2 Gene Reveals Growth-Adaptive Mutations That Modulate Interactions with Scavenger Receptor Class B Type I. J Virol 90:10499-10512
Chou, Chun; Verbaro, Daniel J; Tonc, Elena et al. (2016) The Transcription Factor AP4 Mediates Resolution of Chronic Viral Infection through Amplification of Germinal Center B Cell Responses. Immunity 45:570-82
Durai, Vivek; Murphy, Kenneth M (2016) Functions of Murine Dendritic Cells. Immunity 45:719-736
Brownson, Ross C; Dodson, Elizabeth A; Kerner, Jon F et al. (2016) Framing research for state policymakers who place a priority on cancer. Cancer Causes Control 27:1035-41
Niu, Haixia; Hadwiger, Gayla; Fujiwara, Hideji et al. (2016) Pathways of retinoid synthesis in mouse macrophages and bone marrow cells. J Leukoc Biol 99:797-810
Beeman, Scott C; Shui, Ying-Bo; Perez-Torres, Carlos J et al. (2016) O2 -sensitive MRI distinguishes brain tumor versus radiation necrosis in murine models. Magn Reson Med 75:2442-7
Mertins, Philipp; Mani, D R; Ruggles, Kelly V et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534:55-62
Murphy, Theresa L; Grajales-Reyes, Gary E; Wu, Xiaodi et al. (2016) Transcriptional Control of Dendritic Cell Development. Annu Rev Immunol 34:93-119

Showing the most recent 10 out of 947 publications