The SCC Clinical Trials Core (CTC) provides critical support to Siteman Cancer Center investigators for cancer clinical research. The goal of the CTC Is to facilitate translational research by providing access to an effective, efficient, and economical clinical research team highly specialized in cancer research. Comprehensive services are available through the CTC for all aspects of protocol development, regulatory submissions, study coordination, data management and education and training, all of which will be essential for the SCC's growth in translational clinical research. ? Protocol development staff provide expertise and research assistance in the following areas: study design;protocol and consent form development and editing;facilitating biostatistical support; development of data collection methods;and facilitating development of study-defined database tools. ? Regulatory services include management of all regulatory affairs. These services include protocol submission and processing;trial close-out;Protocol Review &Monitoring Committee (PRMC), Quality Assurance &Safety Monitoring Committee (QASMC), and Human Studies Committee (HSC, WU IRB) submissions;assembling IND applications to the FDA;and interaction with other regulatory agencies and institutional offices [NIH Recombinant DNA Advisory Committee (RAC), Institutional Biosafety Committee (IBC)), Radiation Safety Committee (RSC);Radioactive Drug Research Committee (RDRC), Centerfor Clinical Studies (CCS), Office of Technology Management (OTM)] ? Studv coordination includes services in all aspects of trial conduct and data management, including but not limited to: trial logistics assessment;eligibility verification;study coordination;data collection;record retention;data safety and monitoring reporting;audit and monitoring preparation;adverse event assessment and reporting;and data summary completion for analysis. ? Education and Training of the Clinical Trials staff is provided by an aggressive orientation, training, and tracking program. Additionally, the program provides continuing education opportunities to the staff. This service is currently available to the CTC staff on an ongoing basis. The CTC also assists investigators with identifying potential funding sources, budget and contract development and other study-related activities, and provides clinical trials tools (e.g., SCC protocol Index, Web postings and electronic access to protocol documents).

Public Health Relevance

Clinical studies are essential for moving science from the laboratory into patient care. The Siteman Cancer Center Clinical Trials Core (CTC) promotes excellence in cancer research for human subjects and provides support to all investigators in the cancer center for clinical research activities.

National Institute of Health (NIH)
Center Core Grants (P30)
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Subcommittee B - Comprehensiveness (NCI)
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Washington University
Saint Louis
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Engle, E K; Fisher, D A C; Miller, C A et al. (2015) Clonal evolution revealed by whole genome sequencing in a case of primary myelofibrosis transformed to secondary acute myeloid leukemia. Leukemia 29:869-76
Zihni, Ahmed M; Cavallo, Jaime A; Thompson Jr, Dominic M et al. (2015) Evaluation of absorbable mesh fixation devices at various deployment angles. Surg Endosc 29:1605-13
Rosenbaum, Joan L; Smith, Joan R; Yan, Yan et al. (2015) Impact of a Neonatal-Bereavement-Support DVD on Parental Grief: A Randomized Controlled Trial. Death Stud 39:191-200
Solga, Anne C; Pong, Winnie W; Walker, Jason et al. (2015) RNA-sequencing reveals oligodendrocyte and neuronal transcripts in microglia relevant to central nervous system disease. Glia 63:531-48
Yamada, Tomoko; Yang, Yue; Hemberg, Martin et al. (2014) Promoter decommissioning by the NuRD chromatin remodeling complex triggers synaptic connectivity in the mammalian brain. Neuron 83:122-34
Lewis Jr, James S; Ali, Sahirzeeshan; Luo, Jingqin et al. (2014) A quantitative histomorphometric classifier (QuHbIC) identifies aggressive versus indolent p16-positive oropharyngeal squamous cell carcinoma. Am J Surg Pathol 38:128-37
Griffey, Richard T; Jeffe, Donna B; Bailey, Thomas (2014) Emergency physicians' attitudes and preferences regarding computed tomography, radiation exposure, and imaging decision support. Acad Emerg Med 21:768-77
Jorns, Julie M; Thomas, Dafydd G; Healy, Patrick N et al. (2014) Estrogen receptor expression is high but is of lower intensity in tubular carcinoma than in well-differentiated invasive ductal carcinoma. Arch Pathol Lab Med 138:1507-13
Jeffe, Donna B; Andriole, Dorothy A; Wathington, Heather D et al. (2014) Educational outcomes for students enrolled in MD-PhD programs at medical school matriculation, 1995-2000: a national cohort study. Acad Med 89:84-93
Tait, Sarah; Pacheco, Jose M; Gao, Feng et al. (2014) Body mass index, diabetes, and triple-negative breast cancer prognosis. Breast Cancer Res Treat 146:189-97

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