The developing Bioinformatics Shared Resource in the previous grant submission has been integrated within biostatistics to become the Biostatistics and Bioinformatics Shared Resource (BBISR). With four (full-time) doctoral level faculty biostatisticians, two (part-time) bioinformatics faculty, and two master-level biostatisticians, BBISR staff members collaborate and consult with Winship investigators in the design, conduct, and analysis of preclinical, clinical, laboratory, epidemiologic and molecular cancer investigations. BBISR uses a service support model that draws upon existing Emory University-wide expertise and investment to meet the needs of Winship members. Specifically, BBISR facilitates research by striving to expertly fulfilling the following study components: design (feasibility in meeting study objectives, sample size), recommendations concerning key infrastructure, data analysis, preparations of reports and manuscripts, review of proposals in the Clinical and Translational Research Committee, and development of methods as needed by project. The overall goal of the BBISR is to ensure the use of proper study design and appropriate analysis methods in Winship cancer members'research. BBISR staff members are integrated both locally, within the Winship research programs throughout Emory University, including the Rollins School of Public Health, the Center for Comprehensive Informatics, and with the Atlanta Clinical and Translational Science Institute. Collaborations with Winship investigators have resulted in 51 publications, and BBISR staff members contributing to 38 grant submissions in CY2010. Future plans for this shared resource include the following: strengthening current biostatistics expertise in early phase trial design by a greater integration with genomic data, expanding biostatistics expertise through additional faculty and staff recruitment, building core personnel in bioinformatics, and initiatives towards building devoted informatics support.

Public Health Relevance

The BBISR offers a coordinated approach to cancer research beyond what could be attained by researchers in any single domain. Leveraging its own cancer-specific expertise with the resources of Emory University has helped the BBISR to propose novel solutions to complex problems. In achieving its goals, the BBISR is enabling Winship cancer investigators to achieve theirs.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA138292-04
Application #
8512142
Study Section
Subcommittee G - Education (NCI)
Project Start
2012-08-01
Project End
2017-03-31
Budget Start
2012-08-01
Budget End
2013-03-31
Support Year
4
Fiscal Year
2012
Total Cost
$97,997
Indirect Cost
$35,339
Name
Emory University
Department
Type
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Qi, Q; Kang, S S; Zhang, S et al. (2017) Co-amplification of phosphoinositide 3-kinase enhancer A and cyclin-dependent kinase 4 triggers glioblastoma progression. Oncogene 36:4562-4572
Cornely, Ronald M; Schlingmann, Barbara; Shepherd, Whitney S et al. (2017) Two common human CLDN5 alleles encode different open reading frames but produce one protein isoform. Ann N Y Acad Sci 1397:119-129
Lee, Byoungkoo; Konen, Jessica; Wilkinson, Scott et al. (2017) Local alignment vectors reveal cancer cell-induced ECM fiber remodeling dynamics. Sci Rep 7:39498
Zhong, Jim; Patel, Kirtesh; Switchenko, Jeffrey et al. (2017) Outcomes for patients with locally advanced pancreatic adenocarcinoma treated with stereotactic body radiation therapy versus conventionally fractionated radiation. Cancer 123:3486-3493
Morris, Lydia P; Conley, Andrew B; Degtyareva, Natalya et al. (2017) Genome-wide map of Apn1 binding sites under oxidative stress in Saccharomyces cerevisiae. Yeast 34:447-458
Kim, Yong Joon; Kaluz, Stefan; Mehta, Anil et al. (2017) Purifying Properly Folded Cysteine-rich, Zinc Finger Containing Recombinant Proteins for Structural Drug Targeting Studies: the CH1 Domain of p300 as a Case Example. Bio Protoc 7:
Cassidy, Richard J; Liu, Yuan; Patel, Kirtesh et al. (2017) Can we eliminate neoadjuvant chemoradiotherapy in favor of neoadjuvant multiagent chemotherapy for select stage II/III rectal adenocarcinomas: Analysis of the National Cancer Data base. Cancer 123:783-793
Gavile, Catherine M; Barwick, Benjamin G; Newman, Scott et al. (2017) CD86 regulates myeloma cell survival. Blood Adv 1:2307-2319
Ivanov, A A; Gonzalez-Pecchi, V; Khuri, L F et al. (2017) OncoPPi-informed discovery of mitogen-activated protein kinase kinase 3 as a novel binding partner of c-Myc. Oncogene 36:5852-5860
Fei, Baowei; Guolan Lu; Halicek, Martin T et al. (2017) Label-free hyperspectral imaging and quantification methods for surgical margin assessment of tissue specimens of cancer patients. Conf Proc IEEE Eng Med Biol Soc 2017:4041-4045

Showing the most recent 10 out of 265 publications