The Winship Cancer Institute's Cancer Cell Biology (CCB) Program studies the changes in biological function of human cells as a result of cell transformation. The CCB Program consists of 36 core members from 15 departments across Emory University, including the Schools of Medicine and Public Health and Emory College. The CCB program has two main themes: 1) Cell Survival and Death Mechanisms, and 2) Cell Adhesion, Communication and Metastasis. The CCB Program serves as Winship's scientific switchboard, a platform for discovery of novel signaling pathways, their biological validation, and an interchange of concepts among the CGE, DDT, and CPC Programs. Strategic reorganization toward increased cohesion and clarity has helped make the current project period a highly productive one for the CCB Program. CCB labs identified and targeted key molecular pathways involved in a variety of disease site-specific cancers. Its members published 300 cancer-related publications, many of which appeared in high-impact journals. The program furthered important initiatives, including the establishment of the In Silico Brain Tumor Research Center. Using start-up funding from internal pilot grants, CCB members expanded pilot science into nationally funded projects. CCB Program members currently have $23,452,748 in research grant funding (annual direct costs), of which $19,909,676 is peer-reviewed and $9,489,373 is NCI funded. As Winship's platform for scientific exchange, the CCB Program's productivity has been a win for all of the research programs and has spurred important inter-programmatic collaborations. The program has published 300 cancer-related publications in the current project period, most of which appeared in influential journals. Among these, approximately or neariy 15% represent intra-programmatic and 38% represent inter-programmatic interactions. CCB members and collaborators have contributed to the field of cancer research in a number of significant ways, and the program is poised for continued success going into the next project period.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA138292-05
Application #
8520236
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
5
Fiscal Year
2013
Total Cost
$27,978
Indirect Cost
$10,044
Name
Emory University
Department
Type
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Patel, Kirtesh R; Chowdhary, Mudit; Switchenko, Jeffrey M et al. (2016) BRAF inhibitor and stereotactic radiosurgery is associated with an increased risk of radiation necrosis. Melanoma Res 26:387-94
Berg, Carla J; Stratton, Erin; Esiashvili, Natia et al. (2016) Young Adult Cancer Survivors' Experience with Cancer Treatment and Follow-Up Care and Perceptions of Barriers to Engaging in Recommended Care. J Cancer Educ 31:430-42
Yoshida, Michihiro; He, Peijian; Yun, C Chris (2016) Transgenic Expression of Human Lysophosphatidic Acid Receptor LPA2 in Mouse Intestinal Epithelial Cells Induces Intestinal Dysplasia. PLoS One 11:e0154527
Horton, John R; Liu, Xu; Gale, Molly et al. (2016) Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds. Cell Chem Biol 23:769-81
Bonner, Michael Y; Karlsson, Isabella; Rodolfo, Monica et al. (2016) Honokiol bis-dichloroacetate (Honokiol DCA) demonstrates activity in vemurafenib-resistant melanoma in vivo. Oncotarget 7:12857-68
Bajpai, R; Matulis, S M; Wei, C et al. (2016) Targeting glutamine metabolism in multiple myeloma enhances BIM binding to BCL-2 eliciting synthetic lethality to venetoclax. Oncogene 35:3955-64
Xiao, Canhua; Miller, Andrew H; Felger, Jennifer et al. (2016) A prospective study of quality of life in breast cancer patients undergoing radiation therapy. Adv Radiat Oncol 1:10-16
Owonikoko, Taofeek K; Zhang, Guojing; Kim, Hyun S et al. (2016) Patient-derived xenografts faithfully replicated clinical outcome in a phase II co-clinical trial of arsenic trioxide in relapsed small cell lung cancer. J Transl Med 14:111
Oliver, Daniel E; Patel, Kirtesh R; Switchenko, Jeffrey et al. (2016) Roles of adjuvant and salvage radiotherapy for desmoplastic melanoma. Melanoma Res 26:35-41
Liu, Min; Wang, Hongyan; Lee, Solah et al. (2016) DNA repair pathway choice at various conditions immediately post irradiation. Int J Radiat Biol 92:819-822

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