The mission of the Cell &Molecular Imaging (CMI) Shared Resource is to provide members of the Hollings Cancer Center (HCC) with a fully supported suite of state-of-the-art imaging capabilities. These capabilities include imaging at the cellular, tissue, intravital, and in vivo whole animal levels. Based on significant , expansion of capabilities and services to meet the growing needs of HCC investigators during the first CCSG project period, this resource, led by Dr. John J. Lemasters, Director, and Drs. Anna-Liisa Nieminen and Ann- Marie Broome, Associate Directors, has evolved significantly and now consists of two synergistic and coordinated units - the Confocal &Multiphoton Microscopy Unit and the Small Animal Imaging Unit The integration of these imaging approaches within one shared resource has been undertaken in recognition of the inter-reliance of the emerging techniques as well as the need for investigators to prospectively consider their imaging strategies to effectively transition their research from early cell and tissue studies to whole animal applications with preclinical impact. Since 2009, the CMI Shared Resource has supported research leading to more than 71 publications by 34 investigators representing all HCC research programs and seven MUSC departments. The specific purposes of the HCC CMI Shared Resource are to provide: ? Access to state-of-the-art confocal and multiphoton microscopy for imaging living cells in culture, intravital imaging in live animals, and in vivo small animal imaging, including MRI, fMRI, MR spectroscopy, microCT, microPET, bioluminescence, fluorescence, and X-ray. ? In depth training in multiple imaging modalities, including microscopic techniques, live cell imaging, multiphoton imaging, and pre-clinical in vivo animal imaging. ? Consultation and assistance concerning experimental design, sample preparation, probe selection, data analysis for imaging applications, and transitioning microscopic evaluations to whole animal imaging. Education in the fundamentals of imaging technology and its application, which are essential for appropriate utilization of these approaches, and dissemination of information concerning the ongoing development of novel experimental strategies, emerging technologies, and data analysis techniques.

Public Health Relevance

The Cell &Molecular Imaging Shared Resource at the Hollings Cancer Center provides state-of-the-art instrumentation that supports experiments through cutting-edge imaging technology to reveal critical insights in cancer research!

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
Project #
Application #
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Medical University of South Carolina
United States
Zip Code
Link, Laura A; Howley, Breege V; Hussey, George S et al. (2016) PCBP1/HNRNP E1 Protects Chromosomal Integrity by Translational Regulation of CDC27. Mol Cancer Res 14:634-46
Nelson, Michelle H; Bowers, Jacob S; Bailey, Stefanie R et al. (2016) Toll-like receptor agonist therapy can profoundly augment the antitumor activity of adoptively transferred CD8(+) T cells without host preconditioning. J Immunother Cancer 4:6
Podbielska, Maria; Szulc, Zdzisław M; Kurowska, Ewa et al. (2016) Cytokine-induced release of ceramide-enriched exosomes as a mediator of cell death signaling in an oligodendroglioma cell line. J Lipid Res 57:2028-2039
Sambandam, Yuvaraj; Sakamuri, Sashank; Balasubramanian, Sundaravadivel et al. (2016) RANK Ligand Modulation of Autophagy in Oral Squamous Cell Carcinoma Tumor Cells. J Cell Biochem 117:118-25
Miller, Kayla; Dixit, Suraj; Bredlau, Amy-Lee et al. (2016) Delivery of a drug cache to glioma cells overexpressing platelet-derived growth factor receptor using lipid nanocarriers. Nanomedicine (Lond) 11:581-95
Basher, Fahmin; Jeng, Emily K; Wong, Hing et al. (2016) Cooperative therapeutic anti-tumor effect of IL-15 agonist ALT-803 and co-targeting soluble NKG2D ligand sMIC. Oncotarget 7:814-30
Small, James; Flanagan, Catherine; Armeson, Kent et al. (2016) Family history of cutaneous and noncutaneous malignancies in relation to the risk of keratinocyte carcinoma coupled with another type of cancer: A case-control study. J Am Acad Dermatol 75:1066-1068.e7
Maldonado, Eduardo N; DeHart, David N; Patnaik, Jyoti et al. (2016) ATP/ADP Turnover and Import of Glycolytic ATP into Mitochondria in Cancer Cells Is Independent of the Adenine Nucleotide Translocator. J Biol Chem 291:19642-50
Hendriks, Giel; Derr, Remco S; Misovic, Branislav et al. (2016) The Extended ToxTracker Assay Discriminates Between Induction of DNA Damage, Oxidative Stress, and Protein Misfolding. Toxicol Sci 150:190-203
Paul, Matt R; Levitt, Nicholas P; Moore, David E et al. (2016) Multivariate models from RNA-Seq SNVs yield candidate molecular targets for biomarker discovery: SNV-DA. BMC Genomics 17:263

Showing the most recent 10 out of 311 publications