The mission of the Biostatistics Shared Resource (BSR) is to provide outstanding biostatistics leadership and support in a cost-effective manner for the Hollings Cancer Center (HCC) and to act as a hub that facilitates interactions among the various investigators, other shared resources, and programs within the HCC. Under the leadership of Dr. Elizabeth Garrett-Mayer, the BSR is composed of biostatisticians with in-depth training in cancer research and oncology and complementary expertise in the various approaches used in these endeavors. Dr. Garrett-Mayer utilizes a team-based approach to accomplish the goals of the resource. The success and effectiveness of the HCC BSR are demonstrated by the extent of collaborations since the CCSG was awarded in 2009, resulting in the development of 89 ROI applications and an additional 239 other grant applications {e.g., POI, DOD, T32) through the end of 2012;submission and/or publication of more than 100 manuscripts with BSR members as co-authors;and development of 48 investigator-initiated clinical research studies. The purposes of the BSR are to: * Provide statistical support to HCC investigators for the design of studies, analysis of data, quality control, manuscript preparation, and development of competitive grant proposals. * Adapt, develop, and validate novel statistical methodologies to address emerging approaches in ongoing HCC research. * Facilitate interactions within the HCC by participating in project development meetings with program leaders and other shared resource directors. * Serving on the HCC Protocol Review Committee and Data &Safety Monitoring Committee to provide critical input into proposed and ongoing internal and external clinical trials. * Provide ongoing education in statistical methods and approaches for faculty, fellows, residents and staff of the HCC.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
Project #
Application #
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Medical University of South Carolina
United States
Zip Code
Song, J H; An, N; Chatterjee, S et al. (2015) Deletion of Pim kinases elevates the cellular levels of reactive oxygen species and sensitizes to K-Ras-induced cell killing. Oncogene 34:3728-36
Zemskova, Marina Y; Song, Jin H; Cen, Bo et al. (2015) Regulation of prostate stromal fibroblasts by the PIM1 protein kinase. Cell Signal 27:135-46
Boppana, Nithin B; Kodiha, Mohamed; Stochaj, Ursula et al. (2014) Ceramide synthase inhibitor fumonisin B1 inhibits apoptotic cell death in SCC17B human head and neck squamous carcinoma cells after Pc4 photosensitization. Photochem Photobiol Sci 13:1621-7
God, Jason M; Zhao, Dan; Cameron, Christine A et al. (2014) Disruption of HLA class II antigen presentation in Burkitt lymphoma: implication of a 47,000 MW acid labile protein in CD4+ T-cell recognition. Immunology 142:492-505
Esnaola, Nestor F; Chaudhary, Uzair B; O'Brien, Paul et al. (2014) Phase 2 trial of induction gemcitabine, oxaliplatin, and cetuximab followed by selective capecitabine-based chemoradiation in patients with borderline resectable or unresectable locally advanced pancreatic cancer. Int J Radiat Oncol Biol Phys 88:837-44
Fuseler, John W; Robichaux, Jacqulyne P; Atiyah, Huda I et al. (2014) Morphometric and fractal dimension analysis identifies early neoplastic changes in mammary epithelium of MMTV-cNeu mice. Anticancer Res 34:1171-7
Hussey, Sophie E; Lum, Helen; Alvarez, Andrea et al. (2014) A sustained increase in plasma NEFA upregulates the Toll-like receptor network in human muscle. Diabetologia 57:582-91
Chen, Weiqin; Zhou, Hongyi; Saha, Pradip et al. (2014) Molecular mechanisms underlying fasting modulated liver insulin sensitivity and metabolism in male lipodystrophic Bscl2/Seipin-deficient mice. Endocrinology 155:4215-25
He, Huacheng; Cattran, Alexander W; Nguyen, Tu et al. (2014) Triple-responsive expansile nanogel for tumor and mitochondria targeted photosensitizer delivery. Biomaterials 35:9546-53
Kesarwani, Pravin; Al-Khami, Amir A; Scurti, Gina et al. (2014) Promoting thiol expression increases the durability of antitumor T-cell functions. Cancer Res 74:6036-47

Showing the most recent 10 out of 162 publications