DATABASE & DRUG INTERACTIONS CORE There is a pressing need for a data base that contains relevant quantitative information on combinations of drugs of abuse. The Center for Substance Abuse Research (CSAR) of Temple University is proposing this effort as a new core activity in the Center activities that will be directed by RJ Tallarida. Dr. Tallarida has studied and published extensively in the area of drug combinations That effort, coupled with his numerous worldwide publications on drug combinations, is the basis of new component in this grant renewal application. Many drug combinations are well known for their approved use as well as their use on the street, (e.g., fentanyl + cocaine, heroin + methamphetamine, etc, and extensive combinations that involve alcohol or marijuana). We propose the addition of this core activity that will undertake the development of a data base derived from publications of laboratory-based studies and human use that include drug combinations of special relevance. By that we mean the legitimate medical use of a drug combination as well as common 'street combinations'. The main objective is to search world wide and classify interactions as synergistic, sub-additive or simply additive. This will be accomplished from a newly created website, accessible by all, from our Center on Substance Abuse Research Investigators who study combinations of drugs of abuse are usually guided by awareness of those combinations that are common in street use. The patterns of such drug abuse are well known among law enforcement and regulatory agencies, and it is well documented that many-in fact, all, are potentially dangerous combinations. The danger is enhanced when the drugs interact synergistically in some toxic endpoint. It is therefore especially important to have precise quantitative information on such unusual interactions among these agents that are used recreationally and illegally.
Combination drug use is common in ethical medical usage and in street use. Most often a medical combination is used in order to take advantage of different mechanisms of action in achieving a therapeutic objective. In the ideal situation the use of a drug combination allows lower doses (and less toxicity) of the individual agents. Whether the objective is directed to street use or approved medical use it is important to have quantitative information on the drug combinations, especially synergistic toxic interactions.
|Bogush, Marina; Heldt, Nathan A; Persidsky, Yuri (2017) Blood Brain Barrier Injury in Diabetes: Unrecognized Effects on Brain and Cognition. J Neuroimmune Pharmacol 12:593-601|
|Howlett, Allyn C; Abood, Mary E (2017) CB1 and CB2 Receptor Pharmacology. Adv Pharmacol 80:169-206|
|Mooney, James; Rawls, Scott M (2017) KCNQ2/3 channel agonist flupirtine reduces cocaine place preference in rats. Behav Pharmacol 28:405-407|
|Kim, Jae; Connelly, Krista L; Unterwald, Ellen M et al. (2017) Chemokines and cocaine: CXCR4 receptor antagonist AMD3100 attenuates cocaine place preference and locomotor stimulation in rats. Brain Behav Immun 62:30-34|
|Gherghina, Florin Liviu; Tica, Andrei Adrian; Deliu, Elena et al. (2017) Effects of VPAC1 activation in nucleus ambiguus neurons. Brain Res 1657:297-303|
|Brailoiu, G Cristina; Deliu, Elena; Barr, Jeffrey L et al. (2017) HIV Tat excites D1 receptor-like expressing neurons from rat nucleus accumbens. Drug Alcohol Depend 178:7-14|
|Fakhouri, Lara; Cook, Christopher D; Al-Huniti, Mohammed H et al. (2017) Design, synthesis and biological evaluation of GPR55 agonists. Bioorg Med Chem 25:4355-4367|
|Merkel, Steven F; Andrews, Allison M; Lutton, Evan M et al. (2017) Trafficking of adeno-associated virus vectors across a model of the blood-brain barrier; a comparative study of transcytosis and transduction using primary human brain endothelial cells. J Neurochem 140:216-230|
|Merkel, Steven F; Cannella, Lee Anne; Razmpour, Roshanak et al. (2017) Factors affecting increased risk for substance use disorders following traumatic brain injury: What we can learn from animal models. Neurosci Biobehav Rev 77:209-218|
|Philogene-Khalid, Helene L; Hicks, Callum; Reitz, Allen B et al. (2017) Synthetic cathinones and stereochemistry: S enantiomer of mephedrone reduces anxiety- and depressant-like effects in cocaine- or MDPV-abstinent rats. Drug Alcohol Depend 178:119-125|
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