DATABASE &DRUG INTERACTIONS CORE There is a pressing need for a data base that contains relevant quantitative information on combinations of drugs of abuse. The Center for Substance Abuse Research (CSAR) of Temple University is proposing this effort as a new core activity in the Center activities that will be directed by RJ Tallarida. Dr. Tallarida has studied and published extensively in the area of drug combinations That effort, coupled with his numerous worldwide publications on drug combinations, is the basis of new component in this grant renewal application. Many drug combinations are well known for their approved use as well as their use on the street, (e.g., fentanyl + cocaine, heroin + methamphetamine, etc, and extensive combinations that involve alcohol or marijuana). We propose the addition of this core activity that will undertake the development of a data base derived from publications of laboratory-based studies and human use that include drug combinations of special relevance. By that we mean the legitimate medical use of a drug combination as well as common "street combinations". The main objective is to search world wide and classify interactions as synergistic, sub-additive or simply additive. This will be accomplished from a newly created website, accessible by all, from our Center on Substance Abuse Research Investigators who study combinations of drugs of abuse are usually guided by awareness of those combinations that are common in street use. The patterns of such drug abuse are well known among law enforcement and regulatory agencies, and it is well documented that many-in fact, all, are potentially dangerous combinations. The danger is enhanced when the drugs interact synergistically in some toxic endpoint. It is therefore especially important to have precise quantitative information on such unusual interactions among these agents that are used recreationally and illegally.
Combination drug use is common in ethical medical usage and in street use. Most often a medical combination is used in order to take advantage of different mechanisms of action in achieving a therapeutic objective. In the ideal situation the use of a drug combination allows lower doses (and less toxicity) of the individual agents. Whether the objective is directed to street use or approved medical use it is important to have quantitative information on the drug combinations, especially synergistic toxic interactions.
|Console-Bram, Linda; Brailoiu, Eugen; Brailoiu, Gabriela Cristina et al. (2014) Activation of GPR18 by cannabinoid compounds: a tale of biased agonism. Br J Pharmacol 171:3908-17|
|Miller, Jonathan S; Barr, Jeffrey L; Harper, Lauren J et al. (2014) The GSK3 signaling pathway is activated by cocaine and is critical for cocaine conditioned reward in mice. PLoS One 9:e88026|
|Zhao, Pingwei; Lane, Tom R; Gao, Helen G L et al. (2014) Crucial positively charged residues for ligand activation of the GPR35 receptor. J Biol Chem 289:3625-38|
|Chatila, W M; Criner, G J; Hancock, W W et al. (2014) Blunted expression of miR-199a-5p in regulatory T cells of patients with chronic obstructive pulmonary disease compared to unaffected smokers. Clin Exp Immunol 177:341-52|
|Enman, Nicole M; Zhang, Yong; Unterwald, Ellen M (2014) Connecting the pathology of posttraumatic stress and substance use disorders: monoamines and neuropeptides. Pharmacol Biochem Behav 117:61-9|
|Shi, Xiangdang; Miller, Jonathan S; Harper, Lauren J et al. (2014) Reactivation of cocaine reward memory engages the Akt/GSK3/mTOR signaling pathway and can be disrupted by GSK3 inhibition. Psychopharmacology (Berl) 231:3109-18|
|Kong, Weimin; Li, Hongbo; Tuma, Ronald F et al. (2014) Selective CB2 receptor activation ameliorates EAE by reducing Th17 differentiation and immune cell accumulation in the CNS. Cell Immunol 287:1-17|
|Dimattio, K M; Yakovleva, T V; Aldrich, J V et al. (2014) Zyklophin, a short-acting kappa opioid antagonist, induces scratching in mice. Neurosci Lett 563:155-9|
|Lucchesi, Valentina; Hurst, Dow P; Shore, Derek M et al. (2014) CB2-selective cannabinoid receptor ligands: synthesis, pharmacological evaluation, and molecular modeling investigation of 1,8-Naphthyridin-2(1H)-one-3-carboxamides. J Med Chem 57:8777-91|
|Cathel, Alessandra M; Reyes, Beverly A S; Wang, Qin et al. (2014) Cannabinoid modulation of alpha2 adrenergic receptor function in rodent medial prefrontal cortex. Eur J Neurosci 40:3202-14|
Showing the most recent 10 out of 195 publications