FACILITIES, EQUIPMENT AND OTHER RESOURCES MOLECULAR PROFILING AND CHARACTERIZATION CORE NORTHWESTERN UNIVERSITY The research enterprise at Northwestern University is distinguished by its ability to define and lead interdisciplinary research. From the University culture of cooperation and collaboration, as laid out in the University's strategic plan, interdisciplinary research is identified as one of Northwestern's hallmarks and a foundation upon which Northwestern will build its future. Laboratory: The Kelleher research team develops next-generation proteomics using whole proteins (i.e., the """"""""Top-Down"""""""" approach) and efficiently translates this frontier approach to Northwestern. The team uses a diversity of commercial and custom sample handling approaches, mass spectrometers and software to apply high performance and cutting-edge proteomics to a variety of cell lines, tissues and mammalian tissues/fluids. The research group has two wet labs equipped with chemical fume hoods, biosafety cabinets, vacuum lines, gas lines, ice machines, four-80C freezers, five -20C freezers, two refrigerators and a walk-in cold room. Further, the group has all of the instruments necessary for producing nano-chromatographic columns as well as equipment and tools for both basic machining and electronic test and measure.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Center Core Grants (P30)
Project #
2P30DA018310-11
Application #
8871876
Study Section
Special Emphasis Panel (ZDA1-EXL-T (02))
Project Start
Project End
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
11
Fiscal Year
2014
Total Cost
$246,933
Indirect Cost
$64,087
Name
University of Illinois Urbana-Champaign
Department
Type
DUNS #
041544081
City
Champaign
State
IL
Country
United States
Zip Code
61820
Green, Daniel J; Huang, Rong-Chi; Sudlow, Leland et al. (2018) cAMP, Ca2+, pHi, and NO Regulate H-like Cation Channels That Underlie Feeding and Locomotion in the Predatory Sea Slug Pleurobranchaea californica. ACS Chem Neurosci 9:1986-1993
Rodriguez-Zas, Sandra L; Wu, Cong; Southey, Bruce R et al. (2018) Disruption of microglia histone acetylation and protein pathways in mice exhibiting inflammation-associated depression-like symptoms. Psychoneuroendocrinology 97:47-58
Do, Thanh D; Ellis, Joseph F; Neumann, Elizabeth K et al. (2018) Optically Guided Single Cell Mass Spectrometry of Rat Dorsal Root Ganglia to Profile Lipids, Peptides and Proteins. Chemphyschem 19:1180-1191
Atkins Jr, Norman; Ren, Shifang; Hatcher, Nathan et al. (2018) Functional Peptidomics: Stimulus- and Time-of-Day-Specific Peptide Release in the Mammalian Circadian Clock. ACS Chem Neurosci 9:2001-2008
Tai, Hua-Chia; Checco, James W; Sweedler, Jonathan V (2018) Non-targeted Identification of D-Amino Acid-Containing Peptides Through Enzymatic Screening, Chiral Amino Acid Analysis, and LC-MS. Methods Mol Biol 1719:107-118
Davis, Roderick G; Park, Hae-Min; Kim, Kyunggon et al. (2018) Top-Down Proteomics Enables Comparative Analysis of Brain Proteoforms Between Mouse Strains. Anal Chem 90:3802-3810
Qi, Meng; Philip, Marina C; Yang, Ning et al. (2018) Single Cell Neurometabolomics. ACS Chem Neurosci 9:40-50
Neumann, Elizabeth K; Comi, Troy J; Spegazzini, Nicolas et al. (2018) Multimodal Chemical Analysis of the Brain by High Mass Resolution Mass Spectrometry and Infrared Spectroscopic Imaging. Anal Chem 90:11572-11580
Yang, Ning; Anapindi, Krishna D B; Rubakhin, Stanislav S et al. (2018) Neuropeptidomics of the Rat Habenular Nuclei. J Proteome Res 17:1463-1473
Tillmaand, Emily G; Sweedler, Jonathan V (2018) Integrating Mass Spectrometry with Microphysiological Systems for Improved Neurochemical Studies. Microphysiol Syst 2:

Showing the most recent 10 out of 227 publications