The overall aim of this Core Center of Excellence (CCOE) is to conduct research that will transform etiological models of drug abuse and sexual risk behavior and the prevention programs they inform in general and those for rural African American children, youth, and their families in particular. The need for this transformation is documented by inclusive reviews of drug abuse and sexual risk behavior prevention efforts that reveal mixed and inconsistent results. This inconsistent impact is a major concern that indicates a need for new approaches to etiologic models of drug abuse and sexual risk behavior, particularly greater articulation of the ways in which the interface among genetic, psychosocial, and developmental processes can be used to transform them. To reach this goal we have assembled a team of senior and early career investigators with a successful history of collaboration who have backgrounds in molecular and statistical genetics, genetic epidemiology, public health, human development, and prevention science. This network of investigators will access the Shared Resources Core, a unique combination of data sets, genetic laboratory and specimen repository resources, statistical and bioinformatic services, and data collection and program implementation teams. Data from seven core projects were collected from more than 6,000 African American individuals, approximately 5,000 (83%) of whom live in small towns and rural communities. These data include (a) longitudinal assessments of drug use and abuse and sexual risk behavior phenotypes;(b) genetic data;(c) developmentally appropriate assessments of self-regulatory processes;and (d) multilevel assessments of individual characteristics, social adaptation, parenting/family processes, and neighborhood/community contexts. The organizational and administrative structure of the CCOE will organize and prioritize CCOE scientists'research efforts, providing an integrated process for translating findings into transformations of etiologic models of drug abuse and sexual risk behavior that increase their predictive utility and the efficacy of the prevention progress they inform.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Center Core Grants (P30)
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Special Emphasis Panel (ZDA1-EXL-T (02))
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Crump, Aria
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University of Georgia
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Beach, Steven R H; Lei, Man Kit; Simons, Ronald L et al. (2018) MTHFR regulatory effects on methylation of CG05575921 in response to smoking: Effects are also discernable using MTHFR expression. Am J Med Genet B Neuropsychiatr Genet 177:529-534
Hostinar, Camelia E; Nusslock, Robin; Miller, Gregory E (2018) Future Directions in the Study of Early-Life Stress and Physical and Emotional Health: Implications of the Neuroimmune Network Hypothesis. J Clin Child Adolesc Psychol 47:142-156
Barton, Allen W; Beach, Steven R H; Bryant, Chalandra M et al. (2018) Stress spillover, African Americans' couple and health outcomes, and the stress-buffering effect of family-centered prevention. J Fam Psychol 32:186-196
Chen, E; Miller, G E; Yu, T et al. (2018) Unsupportive parenting moderates the effects of family psychosocial intervention on metabolic syndrome in African American youth. Int J Obes (Lond) 42:634-640
Shaffer, Anne; Whitehead, Monica; Davis, Molly et al. (2018) A Model-Based Cluster Analysis of Maternal Emotion Regulation and Relations to Parenting Behavior. Fam Process 57:707-718
Oshri, Assaf; Duprey, Erinn B; Kogan, Steven M et al. (2018) Growth patterns of future orientation among maltreated youth: A prospective examination of the emergence of resilience. Dev Psychol 54:1456-1471
Lei, Man-Kit; Beach, Steven R H; Simons, Ronald L (2018) Biological embedding of neighborhood disadvantage and collective efficacy: Influences on chronic illness via accelerated cardiometabolic age. Dev Psychopathol 30:1797-1815
Zapolski, Tamika C B; Rowe, Alia T; Banks, Devin E et al. (2018) Perceived Discrimination and Substance Use among Adolescents: Examining the Moderating Effect of Distress Tolerance and Negative Urgency. Subst Use Misuse :1-10
Owens, Max M; Amlung, Michael T; Stojek, Monika et al. (2018) Negative urgency moderates reactivity to laboratory stress inductions. J Abnorm Psychol 127:385-393
Barton, Allen W; Yu, Tianyi; Brody, Gene H et al. (2018) Childhood poverty, catecholamines, and substance use among African American young adults: The protective effect of supportive parenting. Prev Med 112:1-5

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