The overall aim of this Core Center of Excellence (CCOE) is to conduct research that will transform etiological models of drug abuse and sexual risk behavior and the prevention programs they inform in general and those for rural African American children, youth, and their families in particular. The need for this transformation is documented by inclusive reviews of drug abuse and sexual risk behavior prevention efforts that reveal mixed and inconsistent results. This inconsistent impact is a major concern that indicates a need for new approaches to etiologic models of drug abuse and sexual risk behavior, particularly greater articulation of the ways in which the interface among genetic, psychosocial, and developmental processes can be used to transform them. To reach this goal we have assembled a team of senior and early career investigators with a successful history of collaboration who have backgrounds in molecular and statistical genetics, genetic epidemiology, public health, human development, and prevention science. This network of investigators will access the Shared Resources Core, a unique combination of data sets, genetic laboratory and specimen repository resources, statistical and bioinformatic services, and data collection and program implementation teams. Data from seven core projects were collected from more than 6,000 African American individuals, approximately 5,000 (83%) of whom live in small towns and rural communities. These data include (a) longitudinal assessments of drug use and abuse and sexual risk behavior phenotypes;(b) genetic data;(c) developmentally appropriate assessments of self-regulatory processes;and (d) multilevel assessments of individual characteristics, social adaptation, parenting/family processes, and neighborhood/community contexts. The organizational and administrative structure of the CCOE will organize and prioritize CCOE scientists'research efforts, providing an integrated process for translating findings into transformations of etiologic models of drug abuse and sexual risk behavior that increase their predictive utility and the efficacy of the prevention progress they inform.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Center Core Grants (P30)
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Special Emphasis Panel (ZDA1-EXL-T (02))
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Crump, Aria
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University of Georgia
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Hulland, Erin N; Brown, Jennifer L; Swartzendruber, Andrea L et al. (2015) The association between stress, coping, and sexual risk behaviors over 24 months among African-American female adolescents. Psychol Health Med 20:443-56
Brody, Gene H; Yu, Tianyi; Beach, Steven R H et al. (2015) Prevention effects ameliorate the prospective association between nonsupportive parenting and diminished telomere length. Prev Sci 16:171-80
Brody, Gene H; Lei, Man-Kit; Chen, Edith et al. (2014) Neighborhood poverty and allostatic load in African American youth. Pediatrics 134:e1362-8
Miller, Gregory E; Brody, Gene H; Yu, Tianyi et al. (2014) A family-oriented psychosocial intervention reduces inflammation in low-SES African American youth. Proc Natl Acad Sci U S A 111:11287-92
Philibert, Robert A; Beach, S R H; Brody, Gene H (2014) The DNA methylation signature of smoking: an archetype for the identification of biomarkers for behavioral illness. Nebr Symp Motiv 61:109-27
Kogan, Steven M; Lei, Man-Kit; Beach, Steven R H et al. (2014) Dopamine receptor gene d4 polymorphisms and early sexual onset: gender and environmental moderation in a sample of african-american youth. J Adolesc Health 55:235-40
Mackillop, James; Miller, Joshua D; Fortune, Erica et al. (2014) Multidimensional examination of impulsivity in relation to disordered gambling. Exp Clin Psychopharmacol 22:176-85
Swartzendruber, Andrea; Sales, Jessica M; Brown, Jennifer L et al. (2014) Correlates of incident Trichomonas vaginalis infections among African American female adolescents. Sex Transm Dis 41:240-5
Beach, Steven R H; Dogan, Meeshanthini V; Brody, Gene H et al. (2014) Differential impact of cumulative SES risk on methylation of protein-protein interaction pathways as a function of SLC6A4 genetic variation in African American young adults. Biol Psychol 96:28-34
Steiner, Riley J; Swartzendruber, Andrea L; Rose, Eve et al. (2014) Monitoring knowledge among family, sexually transmitted infections, and sexual partnership characteristics of African American adolescent females. Sex Transm Dis 41:601-4

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