The UW P30 Research Core Center Grant from NIDCD provides important infrastructure support for a large research commitment of the University of Washington to the mission areas of NIDCD. The Research Base is composed of 15 grants to 15 investigators with an annual direct cost of over $3 million. In addition, nine grants and one K-award, three R03 grants and one contract are included because they are in the mission area of NIDCD. Four Research Cores provide support for the research programs, and stimulate interactions and collaborations among investigators. Core A, the Human Subjects Recruitment Core, continues the longstanding function of recruiting and scheduling human infant subjects that meet specific criteria for studies on communication sciences and disorders. This Research Core has added services that facilitate recruitment of subjects with specific hearing impairments. Core B, the Computer Resources Core (Computer Core), provides personnel with skills needed for software development for real-time physiological and behavioral investigations of auditory processing in animals and humans. Also, a systems and network manager teaches and advises investigators on optimal computer solutions. Core C, the Imaging Core, provides personnel and equipment maintenance for programs making extensive use of modern digital microscopic imaging methods including confocal microscopy, 3-dimensional reconstructions, and quantitative analyses of cellular attributes. Core D, the Genetics Core, controls breeding and DNA screening for investigators using inbred and genetically manipulated mouse strains. Equipment is provided for rapid analyses of DNA sequences, and for phenotyping hearing and balance disorders to enhance the efficiency of studies using mouse models of communication disorders. The Research Cores are supported by an Administrative Core that oversees the operations of each Research Core, organizes group meetings, provides clerical, fiscal, and personnel support, and prepares reports to the funding agency.

Public Health Relevance

Increasing the efficiency and efficacy of research on hearing, communication and balance will help, in the short term, bring new therapies to the bedside. In the long term, better understanding of the basic normal operation of the organs and systems underlying these functions, as well as the processes leading to disorders, is likely to lead to better prevention and treatment of such disorders and to improved human health.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Center Core Grants (P30)
Project #
5P30DC004661-12
Application #
8122300
Study Section
Special Emphasis Panel (ZDC1-SRB-Q (68))
Program Officer
Platt, Christopher
Project Start
2000-09-25
Project End
2015-08-31
Budget Start
2011-09-01
Budget End
2012-08-31
Support Year
12
Fiscal Year
2011
Total Cost
$727,135
Indirect Cost
Name
University of Washington
Department
Otolaryngology
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Maruthy, Santosh; Feng, Yongqiang; Max, Ludo (2017) Spectral Coefficient Analyses of Word-Initial Stop Consonant Productions Suggest Similar Anticipatory Coarticulation for Stuttering and Nonstuttering Adults. Lang Speech :23830917695853
Minich, Rebecca R; Li, Jin; Tempel, Bruce L (2017) Early growth response protein 1 regulates promoter activity of ?-plasma membrane calcium ATPase 2, a major calcium pump in the brain and auditory system. BMC Mol Biol 18:14
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Horn, David L; Won, Jong Ho; Rubinstein, Jay T et al. (2017) Spectral Ripple Discrimination in Normal-Hearing Infants. Ear Hear 38:212-222
Miller, Christi W; Baylor, Carolyn R; Birch, Kristen et al. (2017) Exploring the Relevance of Items in the Communicative Participation Item Bank (CPIB) for Individuals With Hearing Loss. Am J Audiol 26:27-37
DeVries, Lindsay; Scheperle, Rachel; Bierer, Julie Arenberg (2016) Assessing the Electrode-Neuron Interface with the Electrically Evoked Compound Action Potential, Electrode Position, and Behavioral Thresholds. J Assoc Res Otolaryngol 17:237-52
Miller, Christi W; Bates, Emily; Brennan, Marc (2016) The effects of frequency lowering on speech perception in noise with adult hearing-aid users. Int J Audiol 55:305-12
Esterberg, Robert; Linbo, Tor; Pickett, Sarah B et al. (2016) Mitochondrial calcium uptake underlies ROS generation during aminoglycoside-induced hair cell death. J Clin Invest 126:3556-66
Slowik, Amber D; Bermingham-McDonogh, Olivia (2016) A central to peripheral progression of cell cycle exit and hair cell differentiation in the developing mouse cristae. Dev Biol 411:1-14

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