The UW P30 Research Core Center Grant from NIDCD provides important infrastructure support for a large research commitment of the University of Washington to the mission areas of NIDCD. The Research Base is composed of 15 grants to 15 investigators with an annual direct cost of over $3 million. In addition, nine grants and one K-award, three R03 grants and one contract are included because they are in the mission area of NIDCD. Four Research Cores provide support for the research programs, and stimulate interactions and collaborations among investigators. Core A, the Human Subjects Recruitment Core, continues the longstanding function of recruiting and scheduling human infant subjects that meet specific criteria for studies on communication sciences and disorders. This Research Core has added services that facilitate recruitment of subjects with specific hearing impairments. Core B, the Computer Resources Core (Computer Core), provides personnel with skills needed for software development for real-time physiological and behavioral investigations of auditory processing in animals and humans. Also, a systems and network manager teaches and advises investigators on optimal computer solutions. Core C, the Imaging Core, provides personnel and equipment maintenance for programs making extensive use of modern digital microscopic imaging methods including confocal microscopy, 3-dimensional reconstructions, and quantitative analyses of cellular attributes. Core D, the Genetics Core, controls breeding and DNA screening for investigators using inbred and genetically manipulated mouse strains. Equipment is provided for rapid analyses of DNA sequences, and for phenotyping hearing and balance disorders to enhance the efficiency of studies using mouse models of communication disorders. The Research Cores are supported by an Administrative Core that oversees the operations of each Research Core, organizes group meetings, provides clerical, fiscal, and personnel support, and prepares reports to the funding agency.
Increasing the efficiency and efficacy of research on hearing, communication and balance will help, in the short term, bring new therapies to the bedside. In the long term, better understanding of the basic normal operation of the organs and systems underlying these functions, as well as the processes leading to disorders, is likely to lead to better prevention and treatment of such disorders and to improved human health.
|Esterberg, Robert; Linbo, Tor; Pickett, Sarah B et al. (2016) Mitochondrial calcium uptake underlies ROS generation during aminoglycoside-induced hair cell death. J Clin Invest 126:3556-66|
|Cramer, Karina S; Rubel, Edwin W (2016) Glial Cell Contributions to Auditory Brainstem Development. Front Neural Circuits 10:83|
|Miller, Christi W; Bates, Emily; Brennan, Marc (2016) The effects of frequency lowering on speech perception in noise with adult hearing-aid users. Int J Audiol 55:305-12|
|Slowik, Amber D; Bermingham-McDonogh, Olivia (2016) A central to peripheral progression of cell cycle exit and hair cell differentiation in the developing mouse cristae. Dev Biol 411:1-14|
|Seidl, Armin H; Rubel, Edwin W (2016) Systematic and differential myelination of axon collaterals in the mammalian auditory brainstem. Glia 64:487-94|
|Drennan, Ward R; Won, Jong Ho; Timme, Alden O et al. (2016) Nonlinguistic Outcome Measures in Adult Cochlear Implant Users Over the First Year of Implantation. Ear Hear 37:354-64|
|Chun, Ingyu; Billings, Curtis J; Miller, Christi W et al. (2016) Aided Electrophysiology Using Direct Audio Input: Effects of Amplification and Absolute Signal Level. Am J Audiol 25:14-24|
|Daliri, Ayoub; Max, Ludo (2016) Modulation of Auditory Responses to Speech vs. Nonspeech Stimuli during Speech Movement Planning. Front Hum Neurosci 10:234|
|Bierer, Julie A; Litvak, Leonid (2016) Reducing Channel Interaction Through Cochlear Implant Programming May Improve Speech Perception: Current Focusing and Channel Deactivation. Trends Hear 20:|
|Luo, Chuan; Omelchenko, Irina; Manson, Robert et al. (2015) Direct Intracochlear Acoustic Stimulation Using a PZT Microactuator. Trends Hear 19:|
Showing the most recent 10 out of 268 publications