This application requests support to continue the productive work of the University of Michigan Hearing Research Core Center to enhance the quality and scope of NIDCD-mission oriented research. We are excited to expand this core to embrace three additional regional research facilities, comprising a total of 38 projects by 29 investigators, supported by $6,886,426 annual direct cost. The application builds on experience gained from the previous P30 grant and will continue, and expand, the currently successful core services. As a major new goal, it adds a novel approach to foster interactions and collaborations among auditory and vestibular scientists at the University of Michigan, Michigan State University, Wayne State University, and University of Toledo. The Scientific Synergy Core A will bring together these scientists for discussions, workshops, and meetings of scientific affinity groups to promote new collaborations and enhance the quality and scope of research. Investigators will be supported by three scientific cores offering resources, training, and services in auditory physiology (Core B), cell and molecular biology (Core C), and substance delivery to the inner ear (Core D). A technical Core E will design and manufacture specialized electronic and mechanical instruments, as well as consult in computing-related issues. Cores will be supervised by expert core directors and staffed with experienced personnel. The overall responsibility for the direction and operation of the Center will rest with its director. The day-to-day planning and operation of each core will be the responsibility of the core directors, with standard procedures for scheduling, prioritization of services, and quality control. The Core Center director will be assisted by an administrative staff for the coordination of all activities, monitoring of funds, personnel issues, and reporting requirements to the granting agency. Within the intellectual environment generated by the Scientific Synergy Core and the availability of these resources, this Center will promote interactions and multidisciplinary research by providing novel methodologies, standardized analytical tools, and the exchange of technological experience. Regular meetings of the core users, the affinity groups, and the entire Center research community will assure the best possible implementation of collaborations and effective use of research support.

National Institute of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
Center Core Grants (P30)
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Study Section
Special Emphasis Panel (ZDC1-SRB-O (12))
Program Officer
Platt, Christopher
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University of Michigan Ann Arbor
Schools of Medicine
Ann Arbor
United States
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Choo, Daniel I; Tawfik, Kareem O; Martin, Donna M et al. (2017) Inner ear manifestations in CHARGE: Abnormalities, treatments, animal models, and progress toward treatments in auditory and vestibular structures. Am J Med Genet C Semin Med Genet 175:439-449
Yang, Chao-Hui; Liu, Zhiqi; Dong, Deanna et al. (2017) Histone Deacetylase Inhibitors Are Protective in Acute but Not in Chronic Models of Ototoxicity. Front Cell Neurosci 11:315
Walline, Heather M; Goudsmit, Christine M; McHugh, Jonathan B et al. (2017) Integration of high-risk human papillomavirus into cellular cancer-related genes in head and neck cancer cell lines. Head Neck 39:840-852
Schaefer, Stacy A; Higashi, Atsuko Y; Loomis, Benjamin et al. (2017) From otic induction to hair cell production: Pax2EGFP cell line illuminates key stages of development in mouse inner ear organoid model. Stem Cells Dev :
Munnamalai, Vidhya; Sienknecht, Ulrike J; Duncan, R Keith et al. (2017) Wnt9a Can Influence Cell Fates and Neural Connectivity across the Radial Axis of the Developing Cochlea. J Neurosci 37:8975-8988
Schvartz-Leyzac, Kara C; Pfingst, Bryan E (2017) Assessing the Relationship Between the Electrically Evoked Compound Action Potential and Speech Recognition Abilities in Bilateral Cochlear Implant Recipients. Ear Hear :
Morley, Barbara J; Dolan, David F; Ohlemiller, Kevin K et al. (2017) Generation and Characterization of ?9 and ?10 Nicotinic Acetylcholine Receptor Subunit Knockout Mice on a C57BL/6J Background. Front Neurosci 11:516
Pfingst, Bryan E; Colesa, Deborah J; Swiderski, Donald L et al. (2017) Neurotrophin Gene Therapy in Deafened Ears with Cochlear Implants: Long-term Effects on Nerve Survival and Functional Measures. J Assoc Res Otolaryngol 18:731-750
Schvartz-Leyzac, Kara C; Zwolan, Teresa A; Pfingst, Bryan E (2017) Effects of electrode deactivation on speech recognition in multichannel cochlear implant recipients. Cochlear Implants Int 18:324-334
Klimpel, Katarina E M; Lee, Min Young; King, W. Michael et al. (2017) Vestibular dysfunction in the adult CBA/CaJ mouse after lead and cadmium treatment. Environ Toxicol 32:869-876

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