This application requests support to continue the productive work of the Hearing, Balance and Chemical Senses Research Core Center to enhance the quality and scope of NIDCD-mission oriented research. The proposal builds on experience gained from the two previous P30 grant periods including the successful introduction of the Scientific Synergy Core (Core A) a novel approach to foster interactions and collaborations among scientists at the University of Michigan, Michigan State University, Wayne State University, and University of Toledo. A new development is a broadening of the Core, adding services in the vestibular system and the chemical senses and bringing in investigators studying speech and language pathology. Investigators will continue to be supported by two scientific cores offering resources, training, and services in physiology and behavior (Core B) and cell and molecular biology (Core C). The Instrument Design and Technical Services Core (Core D) will design and manufacture specialized electronic and mechanical instruments as well as consult in computing-related issues. Cores will be supervised by expert core directors and staffed with experienced personnel. The key aims across all the Cores remain to:
Aim 1 : Enhance and extend the quality and scope of the individual research projects of Core participants.
Aim 2 : Improve efficiency and productivity of research within the user group.
Aim 3 : Develop methods and approaches to meet current user needs and to anticipate future needs.
Aim 4 : Provide education, develop collaborations and bring new people into the field. Within the intellectual environment generated by the Scientific Synergy Core and the availability of these resources, this Center will promote interactions and multidisciplinary research by providing novel methodologies, standardized analytical tools, and the exchange of technological experience. It will continue to generate new users and collaborations attracted by the Core services and interactions. Regular meetings of the core users, the affinity groups, and the entire Center research community will assure the best possible implementation of collaborations and effective use of research support.
The purpose of this grant is to enhance and extend the research of multiple investigators towards increasing the understanding of disorders of hearing, balance, taste and smell and developing the ability to prevent and treat these disorders. It will also provide mechanisms to encourage and increase collaborations among its research base, bring new researchers into the field as well as educate the user base on new methods and approaches.
|Shore, Susan E; Roberts, Larry E; Langguth, Berthold (2016) Maladaptive plasticity in tinnitus--triggers, mechanisms and treatment. Nat Rev Neurol 12:150-60|
|Schvartz-Leyzac, Kara C; Pfingst, Bryan E (2016) Across-site patterns of electrically evoked compound action potential amplitude-growth functions in multichannel cochlear implant recipients and the effects of the interphase gap. Hear Res 341:50-65|
|Srivastava, Anshika; Ritesh, K C; Tsan, Yao-Chang et al. (2016) De novo dominant ASXL3 mutations alter H2A deubiquitination and transcription in Bainbridge-Ropers syndrome. Hum Mol Genet 25:597-608|
|Zhou, Ning; Pfingst, Bryan E (2016) Evaluating multipulse integration as a neural-health correlate in human cochlear-implant users: Relationship to forward-masking recovery. J Acoust Soc Am 139:EL70-5|
|Walline, Heather M; Komarck, Christine M; McHugh, Jonathan B et al. (2016) Genomic Integration of High-Risk HPV Alters Gene Expression in Oropharyngeal Squamous Cell Carcinoma. Mol Cancer Res 14:941-952|
|Lee, Min Young; Kurioka, Takaomi; Nelson, Megan M et al. (2016) Viral-mediated Ntf3 overexpression disrupts innervation and hearing in nondeafened guinea pig cochleae. Mol Ther Methods Clin Dev 3:16052|
|Rudy, Shannon F; Brenner, J Chad; Harris, Jennifer L et al. (2016) In vivo Wnt pathway inhibition of human squamous cell carcinoma growth and metastasis in the chick chorioallantoic model. J Otolaryngol Head Neck Surg 45:26|
|Klimpel, Katarina E M; Lee, Min Young; Michael King, W et al. (2016) Vestibular dysfunction in the adult CBA/CaJ mouse after lead and cadmium treatment. Environ Toxicol :|
|Yokota, Yusuke; Bradley, Robert M (2016) Receptive field size, chemical and thermal responses, and fiber conduction velocity of rat chorda tympani geniculate ganglion neurons. J Neurophysiol 115:3062-72|
|Scheel, Adam; Bellile, Emily; McHugh, Jonathan B et al. (2016) Classification of TP53 mutations and HPV predict survival in advanced larynx cancer. Laryngoscope 126:E292-9|
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