This application requests support to continue the productive work of the Hearing, Balance and Chemical Senses Research Core Center to enhance the quality and scope of NIDCD-mission oriented research. The proposal builds on experience gained from the two previous P30 grant periods including the successful introduction of the Scientific Synergy Core (Core A) a novel approach to foster interactions and collaborations among scientists at the University of Michigan, Michigan State University, Wayne State University, and University of Toledo. A new development is a broadening of the Core, adding services in the vestibular system and the chemical senses and bringing in investigators studying speech and language pathology. Investigators will continue to be supported by two scientific cores offering resources, training, and services in physiology and behavior (Core B) and cell and molecular biology (Core C). The Instrument Design and Technical Services Core (Core D) will design and manufacture specialized electronic and mechanical instruments as well as consult in computing-related issues. Cores will be supervised by expert core directors and staffed with experienced personnel. The key aims across all the Cores remain to:
Aim 1 : Enhance and extend the quality and scope of the individual research projects of Core participants.
Aim 2 : Improve efficiency and productivity of research within the user group.
Aim 3 : Develop methods and approaches to meet current user needs and to anticipate future needs.
Aim 4 : Provide education, develop collaborations and bring new people into the field. Within the intellectual environment generated by the Scientific Synergy Core and the availability of these resources, this Center will promote interactions and multidisciplinary research by providing novel methodologies, standardized analytical tools, and the exchange of technological experience. It will continue to generate new users and collaborations attracted by the Core services and interactions. Regular meetings of the core users, the affinity groups, and the entire Center research community will assure the best possible implementation of collaborations and effective use of research support.

Public Health Relevance

The purpose of this grant is to enhance and extend the research of multiple investigators towards increasing the understanding of disorders of hearing, balance, taste and smell and developing the ability to prevent and treat these disorders. It will also provide mechanisms to encourage and increase collaborations among its research base, bring new researchers into the field as well as educate the user base on new methods and approaches.

National Institute of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZDC1-SRB-L (49))
Program Officer
Platt, Christopher
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Michigan Ann Arbor
Schools of Medicine
Ann Arbor
United States
Zip Code
Heeringa, Amarins N; Wu, Calvin; Shore, Susan E (2018) Multisensory Integration Enhances Temporal Coding in Ventral Cochlear Nucleus Bushy Cells. J Neurosci 38:2832-2843
Schvartz-Leyzac, Kara C; Pfingst, Bryan E (2018) Assessing the Relationship Between the Electrically Evoked Compound Action Potential and Speech Recognition Abilities in Bilateral Cochlear Implant Recipients. Ear Hear 39:344-358
Altschuler, Richard A; Halsey, Karin; Kanicki, Ariane et al. (2018) Small Arms Fire-like noise: Effects on Hearing Loss, Gap Detection and the Influence of Preventive Treatment. Neuroscience :
Devare, Jenna; Gubbels, Samuel; Raphael, Yehoash (2018) Outlook and future of inner ear therapy. Hear Res 368:127-135
Avenarius, Matthew R; Jung, Jae-Yun; Askew, Charles et al. (2018) Grxcr2 is required for stereocilia morphogenesis in the cochlea. PLoS One 13:e0201713
Carlson, Krystin; Schacht, Jochen; Neitzel, Richard L (2018) Assessing ototoxicity due to chronic lead and cadmium intake with and without noise exposure in the mature mouse. J Toxicol Environ Health A 81:1041-1057
Schaefer, Stacy A; Higashi, Atsuko Y; Loomis, Benjamin et al. (2018) From Otic Induction to Hair Cell Production: Pax2EGFP Cell Line Illuminates Key Stages of Development in Mouse Inner Ear Organoid Model. Stem Cells Dev 27:237-251
Heeringa, Amarins N; Wu, Calvin; Chung, Christopher et al. (2018) Glutamatergic Projections to the Cochlear Nucleus are Redistributed in Tinnitus. Neuroscience 391:91-103
Altschuler, R A; Kanicki, A; Martin, C et al. (2018) Rapamycin but not acarbose decreases age-related loss of outer hair cells in the mouse Cochlea. Hear Res 370:11-15
Yao, Hui; Hill, Sophie F; Skidmore, Jennifer M et al. (2018) CHD7 represses the retinoic acid synthesis enzyme ALDH1A3 during inner ear development. JCI Insight 3:

Showing the most recent 10 out of 287 publications