This Core will provide advanced computer, electronic and information technology to the Core Center participants by developing, refining and upgrading computer programs for capturing and analyzing data, by designing and building computer interfaces and commercially unavailable electronic equipment and by maintaining network interactions among collaborators. The Core will be directed by Dr. Theodore Raphan, Ph.D., Distinguished Professor of Computer and Information Science at Brooklyn College, City University of New York. The Core will be realized at two locations. At Mount Sinai, a Programmer/Engineer, Dmitri Ogorodnikov, M.S., will be responsible for the design and construction of experimental equipment, using advanced electronic and radio frequency technology. He will write computer programs for control of the vestibular rotators, linear sleds and centrifuges, and he will also upgrade programs for data collection and for analysis of eye movement and single unit data in the animal experiments. An Electronic Technician, whom he will supervise, will aid him. The technician?s primary responsibilities will be to fabricate computer interfaces and electronic equipment, to maintain and upgrade computers and electronic equipment and to update network interfaces. At Brooklyn College, Dr. Danje Zhu, Ph.D., working under the supervision of Dr. Raphan, will write programs to provide real-time analysis of video recordings of binocular eye movements in humans in three-dimensions. Dr. Zhu will upgrade the data collection and analysis programs as the definition and frame rate of the video increases. Dr. Raphan will also direct development of new techniques of analysis of head, body and limb movements of humans during locomotion in three-dimensions and of muscle sympathetic nerve activity using wavelet transforms. The division of labor between Brooklyn and Mount Sinai will optimize the programming strengths that exist in the Department of Computer and Information Science at Brooklyn with the technical expertise of Mr. Ogorodnikov at Mount Sinai. This Core will provide us with the programming strengths and electronic and engineering capabilities that will be required to meet the needs of the experimental group at Mount Sinai. In so doing, it will strengthen our research and enhance interaction across the Core Center.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Center Core Grants (P30)
Project #
1P30DC005204-01A1
Application #
6555342
Study Section
Special Emphasis Panel (ZDC1)
Project Start
2002-07-01
Project End
2007-06-30
Budget Start
Budget End
Support Year
1
Fiscal Year
2002
Total Cost
Indirect Cost
Name
Brooklyn College, CUNY
Department
Type
DUNS #
City
State
Country
Zip Code
Yakushin, Sergei B; Raphan, Theodore; Cohen, Bernard (2017) Coding of Velocity Storage in the Vestibular Nuclei. Front Neurol 8:386
Raphan, Theodore; Cohen, Bernard; Xiang, Yongqing et al. (2016) A Model of Blood Pressure, Heart Rate, and Vaso-Vagal Responses Produced by Vestibulo-Sympathetic Activation. Front Neurosci 10:96
Dai, Mingjia; Cohen, Bernard; Smouha, Eric et al. (2014) Readaptation of the vestibulo-ocular reflex relieves the mal de debarquement syndrome. Front Neurol 5:124
Yakushin, Sergei B; Martinelli, Giorgio P; Raphan, Theodore et al. (2014) Vasovagal oscillations and vasovagal responses produced by the vestibulo-sympathetic reflex in the rat. Front Neurol 5:37
Cohen, Bernard; Martinelli, Giorgio P; Raphan, Theodore et al. (2013) The vasovagal response of the rat: its relation to the vestibulosympathetic reflex and to Mayer waves. FASEB J 27:2564-72
Yakushin, Sergei B (2012) Tuning of gravity-dependent and gravity-independent vertical angular VOR gain changes by frequency of adaptation. J Neurophysiol 107:3349-56
Holstein, Gay R; Friedrich Jr, Victor L; Martinelli, Giorgio P et al. (2012) Fos expression in neurons of the rat vestibulo-autonomic pathway activated by sinusoidal galvanic vestibular stimulation. Front Neurol 3:4
Xiang, Yongqing; Yakushin, Sergei B; Raphan, Theodore (2012) Modeling spatial tuning of adaptation of the angular vestibulo-ocular reflex. Exp Brain Res 220:165-78
Cohen, Bernard; Dai, Mingjia; Ogorodnikov, Dmitri et al. (2011) Motion sickness on tilting trains. FASEB J 25:3765-74
Kolesnikova, Olga V; Raphan, Theodore; Cohen, Bernard et al. (2011) Orientation adaptation of eye movement-related vestibular neurons due to prolonged head tilt. Ann N Y Acad Sci 1233:214-8

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